Quantitative measurement of skeletal muscle oxygenation by combined near infrared time resolved and unresolved spectroscopy

1993 ◽  
Author(s):  
Marco Ferrari
Keyword(s):  
Skeletal Muscle ◽  
Quantitative Measurement ◽  
Near Infrared ◽  
Muscle Oxygenation ◽  
Time Resolved ◽  
Skeletal Muscle Oxygenation

Oxygen delivery-utilization mismatch in contracting locomotor muscle in COPD: peripheral factors

2015 ◽  
Vol 308 (2) ◽  
pp. R105-R111 ◽  
Author(s):  
Wladimir M. Medeiros ◽  
Mari C. T. Fernandes ◽  
Diogo P. Azevedo ◽  
Flavia F. M. de Freitas ◽  
Beatriz C. Amorim ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Near Infrared ◽  
Neuromuscular Electrical Stimulation ◽  
Muscle Oxygenation ◽  
Whole Body ◽  
Chronic Obstructive ◽  
Copd Patients ◽  
Skeletal Muscle Oxygenation ◽  
Severe Copd

Central cardiorespiratory and gas exchange limitations imposed by chronic obstructive pulmonary disease (COPD) impair ambulatory skeletal muscle oxygenation during whole body exercise. This investigation tested the hypothesis that peripheral factors per se contribute to impaired contracting lower limb muscle oxygenation in COPD patients. Submaximal neuromuscular electrical stimulation (NMES; 30, 40, and 50 mA at 50 Hz) of the quadriceps femoris was employed to evaluate contracting skeletal muscle oxygenation while minimizing the influence of COPD-related central cardiorespiratory constraints. Fractional O2 extraction was estimated by near-infrared spectroscopy (deoxyhemoglobin/myoglobin concentration; deoxy-[Hb/Mb]), and torque output was measured by isokinetic dynamometry in 15 nonhypoxemic patients with moderate-to-severe COPD (SpO2 = 94 ± 2%; FEV1 = 46.4 ± 10.1%; GOLD II and III) and in 10 age- and gender-matched sedentary controls. COPD patients had lower leg muscle mass than controls (LMM = 8.0 ± 0.7 kg vs. 8.9 ± 1.0 kg, respectively; P < 0.05) and produced relatively lower absolute and LMM-normalized torque across the range of NMES intensities ( P < 0.05 for all). Despite producing less torque, COPD patients had similar deoxy-[Hb/Mb] amplitudes at 30 and 40 mA ( P > 0.05 for both) and higher deoxy-[Hb/Mb] amplitude at 50 mA ( P < 0.05). Further analysis indicated that COPD patients required greater fractional O2 extraction to produce torque (i.e., ↑Δdeoxy-[Hb/Mb]/torque) relative to controls ( P < 0.05 for 40 and 50 mA) and as a function of NMES intensity ( P < 0.05 for all). The present data obtained during submaximal NMES of small muscle mass indicate that peripheral abnormalities contribute mechanistically to impaired contracting skeletal muscle oxygenation in nonhypoxemic, moderate-to-severe COPD patients.

scholarly journals Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude

Critical Care ◽  
2009 ◽  
Vol 13 (Suppl 5) ◽  
pp. S7 ◽  
Author(s):  
Daniel S Martin ◽  
Denny ZH Levett ◽  
Michael Mythen ◽  
Mike PW Grocott ◽  
Keyword(s):  
Skeletal Muscle ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Muscle Oxygenation ◽  
Skeletal Muscle Oxygenation

scholarly journals Compression Stockings Suppressed Reduced Muscle Blood Volume and Oxygenation Levels Induced by Persistent Sitting

2019 ◽  
Vol 9 (9) ◽  
pp. 1800 ◽  
Author(s):  
Misato Kinoshita ◽  
Yuko Kurosawa ◽  
Sayuri Fuse ◽  
Riki Tanaka ◽  
Nobuko Tano ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Volume ◽  
Near Infrared ◽  
Lower Extremities ◽  
Intracellular Water ◽  
Muscle Oxygenation ◽  
Compression Stocking ◽  
Extracellular Water ◽  
Compression Stockings ◽  
Time Resolved

This study quantitatively analyzed the effects of 3 h of constant sitting on skeletal muscle oxygenation in the lower extremities, using near-infrared time-resolved spectroscopy (NIRTRS). The effects of compression stockings were also evaluated. Eleven healthy men (age, 30.0 ± 6.7 years) maintained their knee joints at 90° flexion during 3 h of constant sitting and wore a compression stocking on either the right or left leg. The side the stocking was worn was chosen randomly. Subsequently, leg circumference and extracellular water were measured. After 3 h of sitting, both factors increased significantly in uncompressed limbs. Furthermore, intracellular water and muscle oxygenation had significantly decreased. In contrast, extracellular water had not increased in the limbs wearing compression stockings. Furthermore, the increased circumference of compressed limbs was significantly smaller than that of uncompressed limbs. Decreases in oxygenated hemoglobin and total hemoglobin were significantly smaller in compressed limbs than in uncompressed limbs (oxy-Hb; p = 0.021, total-Hb; p = 0.013). Three hours of sitting resulted in decreased intracellular water and increased extracellular water in the lower extremities, leading to reduced blood volume and oxygenation levels in skeletal muscle. Compression stockings successfully suppressed these negative effects.

scholarly journals Monitoring of skeletal muscle oxygenation using near-infrared spectroscopy during abdominal aortic surgery

2002 ◽  
Vol 16 (2) ◽  
pp. 127-130 ◽  
Author(s):  
Masayasu Nakayama ◽  
Soushi Iwasaki ◽  
Hiromichi Ichinose ◽  
Shuji Yamamoto ◽  
Noriaki Kanaya ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Aortic Surgery ◽  
Muscle Oxygenation ◽  
Abdominal Aortic Surgery ◽  
Abdominal Aortic ◽  
Skeletal Muscle Oxygenation

A modular NIRS system for clinical measurement of impaired skeletal muscle oxygenation

2000 ◽  
Vol 88 (1) ◽  
pp. 315-325 ◽  
Author(s):  
Ramesh Wariar ◽  
John N. Gaffke ◽  
Ronald G. Haller ◽  
Loren A. Bertocci
Keyword(s):  
Skeletal Muscle ◽  
Near Infrared ◽  
Tissue Oxygenation ◽  
Reactive Hyperemia ◽  
Muscle Oxygenation ◽  
System Stability ◽  
Infrared Spectrometry ◽  
Skeletal Muscle Oxygenation

Near-infrared spectrometry (NIRS) is a well-known method used to measure in vivo tissue oxygenation and hemodynamics. This method is used to derive relative measures of hemoglobin (Hb) + myoglobin (Mb) oxygenation and total Hb (tHb) accumulation from measurements of optical attenuation at discrete wavelengths. We present the design and validation of a new NIRS oxygenation analyzer for the measurement of muscle oxygenation kinetics. This design optimizes optical sensitivity and detector wavelength flexibility while minimizing component and construction costs. Using in vitro validations, we demonstrate 1) general optical linearity, 2) system stability, and 3) measurement accuracy for isolated Hb. Using in vivo validations, we demonstrate 1) expected oxygenation changes during ischemia and reactive hyperemia, 2) expected oxygenation changes during muscle exercise, 3) a close correlation between changes in oxyhemoglobin and oxymyoglobin and changes in deoxyhemoglobin and deoxymyoglobin and limb volume by venous occlusion plethysmography, and 4) a minimal contribution from movement artifact on the detected signals. We also demonstrate the ability of this system to detect abnormal patterns of tissue oxygenation in a well-characterized patient with a deficiency of skeletal muscle coenzyme Q10. We conclude that this is a valid system design for the precise, accurate, and sensitive detection of changes in bulk skeletal muscle oxygenation, can be constructed economically, and can be used diagnostically in patients with disorders of skeletal muscle energy metabolism.

scholarly journals The Effects of Acute Ingestion of a High-fat Solution, compared to a High-Carbohydrate Solution, on Skeletal Muscle Oxygenation, Fat Oxidation and Performance During a 2-hour Cycling Effort Followed by a Short Time Trial in Cyclists and Triathletes

2021 ◽  
Vol 3 (122) ◽  
pp. 42-58
Author(s):  
Antoine Jolicoeur Desroches ◽  
Frédéric Domingue ◽  
Louis Laurencelle ◽  
Claude Lajoie
Keyword(s):  
Skeletal Muscle ◽  
Perceived Exertion ◽  
Near Infrared ◽  
Time Trial ◽  
Fat Oxidation ◽  
Muscle Oxygenation ◽  
Skeletal Muscle Oxygenation ◽  
And Performance ◽  
Maximal Effort ◽  
Carbohydrate Solution

This study aimed to determine the effects of consuming a high fat solution (HFS) compared to a high carbohydrate solution (HCS) during a cycling effort on substrate oxidation, muscle oxygenation and performance with cyclists and triathletes. Thirteen men participated in this study (age: 30.4 ± 6.3 y; height: 178.7 ± 6.1 cm; weight: 74.9 ± 6.5 kg; V̇O2 peak: 60.5 ± 7.9 mlO2×kg-1×min-1). The solutions were isocaloric (total of 720 kcal) and were consumed every 20 minutes. Each solution of HFS contained 12.78 g of lipids, 1.33 g of carbohydrates and 0.67 g of proteins, and each solution of HCS contained 28 g of carbohydrates. We measured pulmonary oxygen consumption and skeletal muscle oxygenation, using a Near Infrared Spectrometer (NIRS) during a cycling effort consisting of 2 hours at 65 % of maximal aerobic power (MAP) followed immediately by a 3-minute time-trial (TT). We observed that the consumption of the HFS increased the rate of fat oxidation at the end of the sub-maximal effort (0.61 ± 0.14 vs 0.53 ± 0.17 g×min-1, p < 0.05). We have also shown that the HFS negatively affected the performance in the TT (mean Watts: HCS: 347.0 ± 77.4 vs HFS: 326.5 ± 88.8 W; p < 0.05) and the rating of perceived exertions during the sub-maximal effort (modified Borg Perceived Exertion scale: 1–10) (mean: 3.62 ± 0.58 for HCS vs 4.16 ± 0.62 for HFS; p < 0.05). We did not observe a significant effect of the acute consumption of the HFS compared to the HCS on muscle oxygenation during the cycling effort. Finally, we observed that cyclists who demonstrated a high skeletal muscle deoxygenation relative to their pulmonary oxygen consumption (DHHb/V̇O2) had a higher fat oxidation capacity (higher Fatmax). In conclusion, even though the consumption of HFS increased the rate of fat oxidation at the end of a sub-maximal effort, it did not affect muscle oxygenation and it negatively affected performance and perceived exertion during a time-trial and caused gastro-intestinal distress in some participants. Keywords: Fat oxidation, Skeletal muscle oxygenation, Lipid supplementation, Carbohydrate supplementation, Near Infrared Spectroscopy (NIRS), Cycling, Triathlon.

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