scholarly journals Near‐infrared diffuse correlation spectroscopy: the future of non‐invasive assessment of skeletal muscle oxygenation?

2019 ◽  
Vol 597 (15) ◽  
pp. 3795-3797
Author(s):  
Jay Carr
Keyword(s):  
Skeletal Muscle ◽  
Near Infrared ◽  
Correlation Spectroscopy ◽  
Muscle Oxygenation ◽  
Diffuse Correlation Spectroscopy ◽  
Non Invasive ◽  
The Future ◽  
Skeletal Muscle Oxygenation

Oxygen delivery-utilization mismatch in contracting locomotor muscle in COPD: peripheral factors

2015 ◽  
Vol 308 (2) ◽  
pp. R105-R111 ◽  
Author(s):  
Wladimir M. Medeiros ◽  
Mari C. T. Fernandes ◽  
Diogo P. Azevedo ◽  
Flavia F. M. de Freitas ◽  
Beatriz C. Amorim ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Near Infrared ◽  
Neuromuscular Electrical Stimulation ◽  
Muscle Oxygenation ◽  
Whole Body ◽  
Chronic Obstructive ◽  
Copd Patients ◽  
Skeletal Muscle Oxygenation ◽  
Severe Copd

Central cardiorespiratory and gas exchange limitations imposed by chronic obstructive pulmonary disease (COPD) impair ambulatory skeletal muscle oxygenation during whole body exercise. This investigation tested the hypothesis that peripheral factors per se contribute to impaired contracting lower limb muscle oxygenation in COPD patients. Submaximal neuromuscular electrical stimulation (NMES; 30, 40, and 50 mA at 50 Hz) of the quadriceps femoris was employed to evaluate contracting skeletal muscle oxygenation while minimizing the influence of COPD-related central cardiorespiratory constraints. Fractional O2 extraction was estimated by near-infrared spectroscopy (deoxyhemoglobin/myoglobin concentration; deoxy-[Hb/Mb]), and torque output was measured by isokinetic dynamometry in 15 nonhypoxemic patients with moderate-to-severe COPD (SpO2 = 94 ± 2%; FEV1 = 46.4 ± 10.1%; GOLD II and III) and in 10 age- and gender-matched sedentary controls. COPD patients had lower leg muscle mass than controls (LMM = 8.0 ± 0.7 kg vs. 8.9 ± 1.0 kg, respectively; P < 0.05) and produced relatively lower absolute and LMM-normalized torque across the range of NMES intensities ( P < 0.05 for all). Despite producing less torque, COPD patients had similar deoxy-[Hb/Mb] amplitudes at 30 and 40 mA ( P > 0.05 for both) and higher deoxy-[Hb/Mb] amplitude at 50 mA ( P < 0.05). Further analysis indicated that COPD patients required greater fractional O2 extraction to produce torque (i.e., ↑Δdeoxy-[Hb/Mb]/torque) relative to controls ( P < 0.05 for 40 and 50 mA) and as a function of NMES intensity ( P < 0.05 for all). The present data obtained during submaximal NMES of small muscle mass indicate that peripheral abnormalities contribute mechanistically to impaired contracting skeletal muscle oxygenation in nonhypoxemic, moderate-to-severe COPD patients.

Impact of Changes in Tissue Optical Properties on Near-Infrared Diffuse Correlation Spectroscopy Measures of Skeletal Muscle Blood Flow

2021 ◽  
Author(s):  
Miles F. Bartlett ◽  
Scott M. Jordan ◽  
Dennis M. Hueber ◽  
Michael D. Nelson
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Optical Properties ◽  
Near Infrared ◽  
Muscle Blood Flow ◽  
Reactive Hyperemia ◽  
Correlation Spectroscopy ◽  
Skeletal Muscle Blood Flow ◽  
Diffuse Correlation Spectroscopy ◽  
Tissue Optical Properties

Near-infrared diffuse correlation spectroscopy (DCS) is increasingly utilized to study relative changes in skeletal muscle blood flow. However, most diffuse correlation spectrometers assume that tissue optical properties- such as absorption (μa) and reduced scattering (μ's) coefficients- remain constant during physiological provocations, which is untrue for skeletal muscle. Here, we interrogate how changes in tissue μa and μ's affect DCS calculations of blood flow index (BFI). We recalculated BFI using raw autocorrelation curves and μa/μ's values recorded during a reactive hyperemia protocol in 16 healthy young individuals. First, we show that incorrectly assuming baseline μa and μ's substantially affects peak BFI and BFI slope when expressed in absolute terms (cm2/s, p<0.01) but these differences are abolished when expressed in relative terms (% baseline). Next, to evaluate the impact of physiologic changes in μa and μ's, we compared peak BFI and BFI slope when μa and μ's were held constant throughout the reactive hyperemia protocol versus integrated from a 3s-rolling average. Regardless of approach, group means for peak BFI and BFI slope did not differ. Group means for peak BFI and BFI slope were also similar following ad absurdum analyses, where we simulated supraphysiologic changes in μa/μ's. In both cases, however, we identified individual cases where peak BFI and BFI slope were indeed affected, with this result being driven by relative changes in μa over μ's. Overall, these results provide support for past reports in which μa/μ's were held constant but also advocate for real-time incorporation of μa and μ's moving forward.

scholarly journals Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude

Critical Care ◽  
2009 ◽  
Vol 13 (Suppl 5) ◽  
pp. S7 ◽  
Author(s):  
Daniel S Martin ◽  
Denny ZH Levett ◽  
Michael Mythen ◽  
Mike PW Grocott ◽  
Keyword(s):  
Skeletal Muscle ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Muscle Oxygenation ◽  
Skeletal Muscle Oxygenation

scholarly journals Near-infrared diffuse correlation spectroscopy tracks changes in oxygen delivery and utilization during exercise with and without isolated arterial compression

2020 ◽  
Vol 318 (1) ◽  
pp. R81-R88
Author(s):  
Wesley J. Tucker ◽  
Ryan Rosenberry ◽  
Darian Trojacek ◽  
Belinda Sanchez ◽  
Robert F. Bentley ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Radial Artery ◽  
Brachial Artery ◽  
Oxygen Delivery ◽  
Near Infrared ◽  
Correlation Spectroscopy ◽  
Flow Index ◽  
Artery Blood Flow ◽  
Diffuse Correlation Spectroscopy

Near-infrared diffuse correlation spectroscopy (NIR-DCS) is an emerging technology for simultaneous measurement of skeletal muscle microvascular oxygen delivery and utilization during exercise. The extent to which NIR-DCS can track acute changes in oxygen delivery and utilization has not yet been fully established. To address this knowledge gap, 14 healthy men performed rhythmic handgrip exercise at 30% maximal voluntary contraction, with and without isolated brachial artery compression, designed to acutely reduce convective oxygen delivery to the exercising muscle. Radial artery blood flow (Duplex Ultrasound) and NIR-DCS derived variables [blood flow index (BFI), tissue oxygen saturation ([Formula: see text]), and metabolic rate of oxygen ([Formula: see text])] were simultaneously measured. During exercise, both radial artery blood flow (+51.6 ± 20.3 mL/min) and DCS-derived BFI (+155.0 ± 82.2%) increased significantly ( P < 0.001), whereas [Formula: see text] decreased −7.9 ± 6.2% ( P = 0.002) from rest. Brachial artery compression during exercise caused a significant reduction in both radial artery blood flow (−32.0 ± 19.5 mL/min, P = 0.001) and DCS-derived BFI (−57.3 ± 51.1%, P = 0.01) and a further reduction of [Formula: see text] (−5.6 ± 3.8%, P = 0.001) compared with exercise without compression. [Formula: see text] was not significantly reduced during arterial compression ( P = 0.83) due to compensatory reductions in [Formula: see text], driven by increases in deoxyhemoglobin/myoglobin (+7.1 ± 6.1 μM, P = 0.01; an index of oxygen extraction). Together, these proof-of-concept data help to further validate NIR-DCS as an effective tool to assess the determinants of skeletal muscle oxygen consumption at the level of the microvasculature during exercise.

A review on the non-invasive evaluation of skeletal muscle oxygenation

2016 ◽  
Author(s):  
A. A. A. Halim ◽  
M. H. Laili ◽  
N. A. Aziz ◽  
A. R. Laili ◽  
M. S. Salikin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Oxygenation ◽  
Non Invasive ◽  
Skeletal Muscle Oxygenation ◽  
Invasive Evaluation

scholarly journals Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near‐infrared diffuse correlation spectroscopy

2019 ◽  
Vol 597 (11) ◽  
pp. 2887-2901 ◽  
Author(s):  
Wesley J. Tucker ◽  
Ryan Rosenberry ◽  
Darian Trojacek ◽  
Houda H. Chamseddine ◽  
Carrie A. Arena‐Marshall ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Consumption ◽  
Near Infrared ◽  
Correlation Spectroscopy ◽  
Diffuse Correlation Spectroscopy ◽  
Muscle Oxygen ◽  
Muscle Oxygen Consumption

scholarly journals Monitoring of skeletal muscle oxygenation using near-infrared spectroscopy during abdominal aortic surgery

2002 ◽  
Vol 16 (2) ◽  
pp. 127-130 ◽  
Author(s):  
Masayasu Nakayama ◽  
Soushi Iwasaki ◽  
Hiromichi Ichinose ◽  
Shuji Yamamoto ◽  
Noriaki Kanaya ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Aortic Surgery ◽  
Muscle Oxygenation ◽  
Abdominal Aortic Surgery ◽  
Abdominal Aortic ◽  
Skeletal Muscle Oxygenation
Sign in / Sign up

Export Citation Format

Share Document