Anatomic optical coherence tomography for dynamic imaging of the upper airway

2017 ◽  
Author(s):  
Ruofei Bu ◽  
Santosh Balakrishnan ◽  
Nicusor Iftimia ◽  
Hillel Price ◽  
Carlton Zdanski ◽  
...  
2007 ◽  
Author(s):  
Felix Spöler ◽  
Michael Först ◽  
Heinrich Kurz ◽  
Markus Frentz ◽  
Norbert F. Schrage

2014 ◽  
Vol 5 (3) ◽  
pp. 788 ◽  
Author(s):  
Kushal Wijesundara ◽  
Carlton Zdanski ◽  
Julia Kimbell ◽  
Hillel Price ◽  
Nicusor Iftimia ◽  
...  

2012 ◽  
Vol 17 (11) ◽  
pp. 110507 ◽  
Author(s):  
Joseph Jing ◽  
Jun Zhang ◽  
Anthony Chin Loy ◽  
Brian J. F. Wong ◽  
Zhongping Chen

2017 ◽  
Author(s):  
Anthony Phan ◽  
Karol Karnowski ◽  
Qingyun Lee ◽  
Peter Fejes ◽  
Bryden Quirk ◽  
...  

2012 ◽  
Vol 113 (6) ◽  
pp. 967-974 ◽  
Author(s):  
Robert A. McLaughlin ◽  
Xiaojie Yang ◽  
Bryden C. Quirk ◽  
Dirk Lorenser ◽  
Rodney W. Kirk ◽  
...  

Imaging of alveoli in situ has for the most part been infeasible due to the high resolution required to discern individual alveoli and limited access to alveoli beneath the lung surface. In this study, we present a novel technique to image alveoli using optical coherence tomography (OCT). We propose the use of OCT needle probes, where the distal imaging probe has been miniaturized and encased within a hypodermic needle (as small as 30-gauge, outer diameter 310 μm), allowing insertion deep within the lung tissue with minimal tissue distortion. Such probes enable imaging at a resolution of ∼12 μm within a three-dimensional cylindrical field of view with diameter ∼1.5 mm centered on the needle tip. The imaging technique is demonstrated on excised lungs from three different species: adult rats, fetal sheep, and adult pigs. OCT needle probes were used to image alveoli, small bronchioles, and blood vessels, and results were matched to histological sections. We also present the first dynamic OCT images acquired with an OCT needle probe, allowing tracking of individual alveoli during simulated cyclical lung inflation and deflation.


2015 ◽  
Author(s):  
Andrew L. Lopez ◽  
Shang Wang ◽  
Monica Garcia ◽  
Christian Valladolid ◽  
Kirill V. Larin ◽  
...  

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