Extended dynamic range of Doppler OCT by application of a new method to high density B-scans using a MHz FDML swept laser source (Conference Presentation)

2017 ◽  
Author(s):  
Sahar Elahi ◽  
Lars Thrane ◽  
Andrew M. Rollins ◽  
Michael W. Jenkins
Keyword(s):  
Dynamic Range ◽  
High Density ◽  
New Method ◽  
Laser Source ◽  
Doppler Oct ◽  
Extended Dynamic

scholarly journals Optical whispering-gallery mode barcodes for high-precision and wide-range temperature measurements

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Jie Liao ◽  
Lan Yang
Keyword(s):  
High Precision ◽  
Dynamic Range ◽  
Single Mode ◽  
Whispering Gallery Mode ◽  
Temperature Measurements ◽  
Laser Source ◽  
Multiple Modes ◽  
Whispering Gallery ◽  
Wide Range ◽  
Thermal Sensing

AbstractTemperature is one of the most fundamental physical properties to characterize various physical, chemical, and biological processes. Even a slight change in temperature could have an impact on the status or dynamics of a system. Thus, there is a great need for high-precision and large-dynamic-range temperature measurements. Conventional temperature sensors encounter difficulties in high-precision thermal sensing on the submicron scale. Recently, optical whispering-gallery mode (WGM) sensors have shown promise for many sensing applications, such as thermal sensing, magnetic detection, and biosensing. However, despite their superior sensitivity, the conventional sensing method for WGM resonators relies on tracking the changes in a single mode, which limits the dynamic range constrained by the laser source that has to be fine-tuned in a timely manner to follow the selected mode during the measurement. Moreover, we cannot derive the actual temperature from the spectrum directly but rather derive a relative temperature change. Here, we demonstrate an optical WGM barcode technique involving simultaneous monitoring of the patterns of multiple modes that can provide a direct temperature readout from the spectrum. The measurement relies on the patterns of multiple modes in the WGM spectrum instead of the changes of a particular mode. It can provide us with more information than the single-mode spectrum, such as the precise measurement of actual temperatures. Leveraging the high sensitivity of WGMs and eliminating the need to monitor particular modes, this work lays the foundation for developing a high-performance temperature sensor with not only superior sensitivity but also a broad dynamic range.

A new method for the fractionation of human plasma high density lipoprotein

1977 ◽  
Vol 55 (7) ◽  
pp. 766-768 ◽  
Author(s):  
Bernard Rubenstein ◽  
Susan Evans ◽  
George Steiner
Keyword(s):  
High Density Lipoprotein ◽  
Human Plasma ◽  
Density Lipoprotein ◽  
High Density ◽  
New Method ◽  
Continuous Gradient ◽  
Elution Pattern ◽  
Plasma High Density Lipoprotein ◽  
Plasma High Density ◽  
Peptide Composition

We have devised a new method for the fractionation of human plasma high density lipoprotein (HDL). The HDL was chromatographed on DEAE-agarose columns using a continuous gradient of 0.06–0.15 M NaCl. The elution pattern obtained showed three phases, each with differing peptide composition. Examination of the three subfractions showed that each contained both apo A-I and apo A-II, but indifferent proportions. Subfraction 1 contained noapoC-II orC-III-1 and only a trace of apo C-III-2, subfraction 2 contained apo C-II and C-III-1 but no C-III-2, while subfraction 3 contained considerable apo C-III-2 with only traces of apo C-II or C-III-1.

scholarly journals Influence of nanocellulose on the hydration process of Portland cement and concrete properties

2020 ◽  
Vol 17 (5) ◽  
pp. 155-160
Author(s):  
V. I. Khirkhasova ◽  
Keyword(s):  
Mechanical Properties ◽  
Portland Cement ◽  
Physical And Mechanical Properties ◽  
Cement Composite ◽  
High Density ◽  
Strength Characteristics ◽  
New Method ◽  
Concrete Properties ◽  
Hardening Process ◽  
Study Results

The paper deals with modification of cement composite and concrete with nanocellulose in low and high density. The author presents the study results of the influence of nanocellulose on the cement composite hardening process, as well as the physical and mechanical properties of heavy concrete. The influence of the used additive on the rheological and strength characteristics of concrete is revealed. A new method is proposed to improve the material performance.

scholarly journals Photodetector resistant to background light noise with extended dynamic range of input signals

2021 ◽  
pp. 3-8
Author(s):  
V. M. Lipka ◽  
V. V. Ryukhtin ◽  
Yu. G. Dobrovolsky
Keyword(s):  
Dynamic Range ◽  
Automatic Gain Control ◽  
Modulation Frequency ◽  
Low Frequency ◽  
Gain Control ◽  
Ambient Air ◽  
Frequency Range ◽  
Background Light ◽  
Useful Signal ◽  
Extended Dynamic

Measurement of periodic optical information signals in the background light noise with a photodetector with extended dynamic range is an urgent task of modern electronics and thus has become the aim of this study. To increase the dynamic range of the photodetector, a new version of the automatic gain control (AGC) circuit has been developed, which consists of an AGC controller, an output photodetector amplifier and an AGC detector. The authors measured the dynamic range of the photodetector when receiving optical radiation with a wavelength of 1064 nm in the power range from 2.10–8 to 2.10–5 W at a modulation frequency of 20 kHz with the AGC on. Under these conditions, the dynamic range of the photodetector was found to be up to 67 dB. If the AGC was off, the dynamic range did not exceed 30 dB. Thus, the study made it possible to create a photodetector with an extended dynamic range up to 67 dB based on a new version of the AGC circuit. The design of the photodetector allowed choosing a useful signal of a particular modulation frequency in the frequency range from 3 to 45 kHz and effectively suppresses the frequencies caused by optical interference in the low frequency range from the frequency of the input signal of constant amplitude up to 3 kHz inclusive. This compensates the current up to 15 mA, which is equivalent to the power of light interference of about 15 mW. Further research should address the issues of reliability of the proposed photodetector design and optimization of its optical system. The photodetector can be used in geodesy and ambient air quality monitoring.

scholarly journals Optical spectroanalyzer with extended dynamic range for pharmacokinetic investigations of photosensitizers in biotissue

2019 ◽  
Vol 8 (1) ◽  
pp. 46-51 ◽  
Author(s):  
G. A. Meerovich ◽  
E. V. Akhlyustina ◽  
T. A. Savelieva ◽  
K. G. Linkov ◽  
V. B. Loschenov
Keyword(s):  
Dynamic Range ◽  
Spectrum Analyzer ◽  
Pharmacokinetic Studies ◽  
Fluorescent Properties ◽  
Accumulation Time ◽  
Fluorescent Method ◽  
Calibration Samples ◽  
Hardware Circuit ◽  
Improved Accuracy ◽  
Extended Dynamic

Currently, the most promising method for the study of pharmacokinetics of drugs with fluorescent properties is the spectral-fluorescent method. In this article, we propose an algorithm for expanding the dynamic range of the spectrum analyzer by automatically monitoring the maximum spectral density in the recorded fluorescence spectrum and automatically controlled changes in the accumulation time depending on this value, followed by compensation of the output signal with regard to this change, as well as hardware circuit solutions that allow this algorithm.Testing of LESA-01-"Biospeс" spectrum analyzer, upgraded using the proposed approach, was carried out on photosensitizer dispersions based on tetra-3-phenylthiophthalocyanine hydroxyaluminium of various concentrations (from 0.01 mg/l to 50 mg/l), approximately corresponding to the concentrations realized in the process of studying pharmacokinetics in calibration samples and tissues of experimental animals.The proposed solutions that implement the algorithm for recording fluorescence spectra with automatic change of accumulation time depending on the signal level, ensured a significant expansion of the dynamic range of the spectrum analyzer (up to 3.5 orders of magnitude) and improved accuracy in pharmacokinetic studies.

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