Predicting photodynamic therapy efficacy with photoacoustic imaging (Conference Presentation)

2016 ◽  
Author(s):  
Srivalleesha Mallidi ◽  
Zhiming Mai ◽  
Amjad P. Khan ◽  
Tayyaba Hasan
Keyword(s):  
Photodynamic Therapy ◽  
Photoacoustic Imaging ◽  
Therapy Efficacy

Current phthalocyanines delivery systems in photodynamic therapy: an updated review

2021 ◽  
Vol 28 ◽  
Author(s):  
Mariana Miretti ◽  
Cesar German Prucca ◽  
Tomas Cristian Tempesti ◽  
Maria Teresa Baumgartner
Keyword(s):  
Photodynamic Therapy ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Aqueous Media ◽  
Delivery Systems ◽  
Current Status ◽  
Oxygen Species ◽  
Cancer Treatments ◽  
Therapy Efficacy ◽  
Cellular Components

: Photodynamic therapy has emerged as an effective therapeutic alternative to treat oncological, cardiovascular, dermatological, infectious, and ophthalmic diseases. Photodynamic therapy combines the action of a photosensitizer with light in the presence of oxygen to generate reactive oxygen species capable of reacting with cellular components resulting in injury and, consequently, inducing cellular death. Phthalocyanines are considered good photosensitizers, although most of them are lipophilic, difficulting their administration for clinical use. A strategy to overcome the lack of solubility of phthalocyanines in aqueous media is to incorporate them into different delivery systems. The present review aimed to summarize the current status of the main drug delivery systems used for Zn and Al phthalocyanines and their effect in photodynamic therapy, reported in the last five years. Liposomes, polymeric micelles, polymeric nanoparticles, and gold-nanoparticles constituted some of the most used carriers and were discussed in this review. The latest studies reported strongly suggests that the application of nanotechnologies as delivery systems allow an increase in photodynamic therapy efficacy and reduce side-effects associated with the phthalocyanine administration, which represents a promise for cancer treatments.

scholarly journals Applications of Oxygen-Carrying Micro/Nanobubbles: a Potential Approach to Enhance Photodynamic Therapy and Photoacoustic Imaging

2018 ◽  
Author(s):  
M. Saad Khan ◽  
Jangsun Hwang ◽  
Kyungwoo Lee ◽  
Yonghyun Choi ◽  
Kyobum Kim ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Oxygen Supply ◽  
Photoacoustic Imaging ◽  
Supply And Demand ◽  
Flexible Structures ◽  
Synthesis Methods ◽  
Oxygen Species ◽  
Hypoxic Conditions ◽  
Potential Use ◽  
Resistance To Chemotherapy

Microbubbles and nanobubbles can be prepared using various shells, such as phospholipids, polymers, proteins, and surfactants. They are echogenic and can be used as contrast agents for ultrasonic and photoacoustic imaging. These bubbles can be engineered in various sizes as vehicles for gas and drug delivery applications with novel properties and flexible structures. Hypoxic areas in tumors develop owing to an imbalance of oxygen supply and demand. In tumors, hypoxic regions have shown more resistance to chemotherapy, radiotherapy, and photodynamic therapies. The efficacy of photodynamic therapy depends on the availability of oxygen in the tumor to generate reactive oxygen species. Micro/nanobubbles have been shown to reverse hypoxic conditions and increase tissue oxygen levels. This review summarizes the synthesis methods and shell compositions of micro/nanobubbles and methods deployed for oxygen delivery. In addition, the shortcomings and prospects of engineering micro/nanobubbles are discussed for their potential use in photodynamic therapy.

scholarly journals Enhancing the photodynamic therapy efficacy of black phosphorus nanosheets by covalently grafting fullerene C60

2020 ◽  
Vol 11 (42) ◽  
pp. 11435-11442 ◽  
Author(s):  
Yajuan Liu ◽  
Daoming Zhu ◽  
Xianjun Zhu ◽  
Gaoke Cai ◽  
Jianhua Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Black Phosphorus ◽  
Fullerene C60 ◽  
Inhibition Rate ◽  
Tumor Inhibition ◽  
Therapy Efficacy ◽  
Tumor Inhibition Rate

Covalently grafting C60 molecules onto black phosphorus (BP) nanosheets improves their tumor inhibition rate from 36.6% to 88.2%.

scholarly journals Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ

2017 ◽  
Vol 20 ◽  
pp. 227-233 ◽  
Author(s):  
Ana Luiza Ribeiro de Souza ◽  
Ethan LaRochelle ◽  
Kayla Marra ◽  
Jason Gunn ◽  
Scott C. Davis ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Dose Rate ◽  
Low Dose ◽  
Biological Damage ◽  
Therapy Efficacy ◽  
Low Dose Rate

Distribution, Trafficking, and in Vitro Photodynamic Therapy Efficacy of Cholesterol Silicon(IV) Phthalocyanine and Its Nanoparticles in Breast Cancer Cells

2019 ◽  
Vol 2 (12) ◽  
pp. 5976-5984 ◽  
Author(s):  
Xiuqin Chen ◽  
Qiumei Guo ◽  
Shiqing Dong ◽  
Jianling Chen ◽  
Shusen Xie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Therapy Efficacy

Evaluation of cancer imaging potential and photodynamic therapy efficacy of copper (II) benzyloxypheophorbide-a

2014 ◽  
Vol 23 (1) ◽  
pp. 89-95 ◽  
Author(s):  
Kasim Ocakoglu ◽  
Özge Er ◽  
Fatma Yurt Lambrecht ◽  
Sunde Yılmaz Süslüer ◽  
Cağla Kayabasi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Imaging ◽  
Therapy Efficacy
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