Mapping whole-brain activity with cellular resolution by light-sheet microscopy and high-throughput image analysis (Conference Presentation)

2016 ◽  
Author(s):  
Ludovico Silvestri ◽  
Nikita Rudinskiy ◽  
Marco Paciscopi ◽  
Marie Caroline Müllenbroich ◽  
Irene Costantini ◽  
...  
Keyword(s):  
Image Analysis ◽  
High Throughput ◽  
Brain Activity ◽  
Light Sheet ◽  
Whole Brain ◽  
Light Sheet Microscopy ◽  
Cellular Resolution

scholarly journals Quantitative neuroanatomy of all Purkinje cells with light sheet microscopy and high-throughput image analysis

2015 ◽  
Vol 9 ◽  
Author(s):  
Ludovico Silvestri ◽  
Marco Paciscopi ◽  
Paolo Soda ◽  
Filippo Biamonte ◽  
Giulio Iannello ◽  
...  
Keyword(s):  
Image Analysis ◽  
Purkinje Cells ◽  
High Throughput ◽  
Light Sheet ◽  
Light Sheet Microscopy

Whole-brain functional imaging at cellular resolution using light-sheet microscopy

2013 ◽  
Vol 10 (5) ◽  
pp. 413-420 ◽  
Author(s):  
Misha B Ahrens ◽  
Michael B Orger ◽  
Drew N Robson ◽  
Jennifer M Li ◽  
Philipp J Keller
Keyword(s):  
Functional Imaging ◽  
Light Sheet ◽  
Whole Brain ◽  
Light Sheet Microscopy ◽  
Cellular Resolution

scholarly journals High-throughput live imaging using Light Sheet Microscopy

2020 ◽  
Author(s):  
Emilio J. Gualda ◽  
Matteo Bernardello ◽  
Maria Marsal ◽  
Pablo Loza Alvarez
Keyword(s):  
High Throughput ◽  
Light Sheet ◽  
Live Imaging ◽  
Light Sheet Microscopy

scholarly journals Whole-Brain Profiling of Cells and Circuits in Mammals by Tissue Clearing and Light-Sheet Microscopy

Neuron ◽  
2020 ◽  
Vol 106 (3) ◽  
pp. 369-387 ◽  
Author(s):  
Hiroki R. Ueda ◽  
Hans-Ulrich Dodt ◽  
Pavel Osten ◽  
Michael N. Economo ◽  
Jayaram Chandrashekar ◽  
...  
Keyword(s):  
Light Sheet ◽  
Whole Brain ◽  
Tissue Clearing ◽  
Light Sheet Microscopy

scholarly journals A hybrid open-top light-sheet microscope for multi-scale imaging of cleared tissues

2021 ◽  
Author(s):  
Adam Glaser ◽  
Kevin Bishop ◽  
Lindsey Barner ◽  
Etsuo Susaki ◽  
Shimpei Kubota ◽  
...  
Keyword(s):  
Hybrid System ◽  
High Throughput ◽  
Light Sheet ◽  
Refractive Indices ◽  
Volumetric Imaging ◽  
Tissue Clearing ◽  
Sample Geometry ◽  
Multi Scale ◽  
Light Sheet Microscopy ◽  
User Friendly

Abstract Light-sheet microscopy has emerged as the preferred means for high-throughput volumetric imaging of cleared tissues. However, there is a need for a user-friendly system that can address imaging applications with varied requirements in terms of resolution (mesoscopic to sub-micrometer), sample geometry (size, shape, and number), and compatibility with tissue-clearing protocols and sample holders of various refractive indices. We present a ‘hybrid’ system that combines a novel non-orthogonal dual-objective and conventional (orthogonal) open-top light-sheet architecture for versatile multi-scale volumetric imaging.

scholarly journals Subvoxel light-sheet microscopy for high-resolution high-throughput volumetric imaging of large biomedical specimens

2019 ◽  
Vol 1 (01) ◽  
pp. 1 ◽  
Author(s):  
Peng Fei ◽  
Jun Nie ◽  
Juhyun Lee ◽  
Yichen Ding ◽  
Shuoran Li ◽  
...  
Keyword(s):  
High Resolution ◽  
High Throughput ◽  
Light Sheet ◽  
Volumetric Imaging ◽  
Light Sheet Microscopy

scholarly journals Comprehensive optical and data management infrastructure for high-throughput light-sheet microscopy of whole mouse brains

2015 ◽  
Vol 2 (4) ◽  
pp. 041404 ◽  
Author(s):  
M. Caroline Müllenbroich ◽  
Ludovico Silvestri ◽  
Leonardo Onofri ◽  
Irene Costantini ◽  
Marcel van’t Hoff ◽  
...  
Keyword(s):  
Data Management ◽  
High Throughput ◽  
Light Sheet ◽  
Light Sheet Microscopy
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