Assembly and characterization of a fluorescence lifetime spectroscopy system for skin lesions diagnostic

2015 ◽  
Author(s):  
Marcelo Saito Nogueira ◽  
Ramon Gabriel Teixeira Rosa ◽  
Sebastião Pratavieira ◽  
Camila de Paula D´Almeida ◽  
Cristina Kurachi
Keyword(s):  
Fluorescence Lifetime ◽  
Skin Lesions ◽  
Spectroscopy System

scholarly journals On Using a Mobile Application to Support Teledermatology: A Case Study in an Underprivileged Area in Colombia

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Juan Pablo Sáenz ◽  
Mónica Paola Novoa ◽  
Darío Correal ◽  
Bell Raj Eapen
Keyword(s):  
Rural Areas ◽  
Mobile Applications ◽  
Mobile Application ◽  
Correct Diagnosis ◽  
Skin Lesions ◽  
Healthcare Personnel ◽  
Combined Use ◽  
Forest Regions ◽  
The Face

Background. The use of mobile applications in dermatology to support remote diagnosis is gaining acceptance, particularly in rural areas, where dermatology services are commonly managed by healthcare personnel with no specialty training. Moreover, ontologies—sets of concepts that represent knowledge in a given domain—are increasingly being used to support medical diagnosis. A specific case is ONTODerm: an ontology to aid dermatological diagnosis. However, there is little information on the combined use of mobile applications and ontologies as support solutions in dermatology. Objective. Assessing the reliability of ONTODerm as a tool to support remote dermatological diagnosis when used together with a mobile dermatological application in underprivileged areas. Methods. A mobile application that allows characterization of skin lesions was developed, and the information about the lesions was sent to ONTODerm. An exploratory study was conducted in a remote area without access to a dermatologist. A total of 64 dermatological queries were recorded in the application and consulted with ONTODerm. Later, an experienced dermatologist evaluated the characterization and diagnosis of each query to determine the accuracy of the system. Results. The results showed that the probability of obtaining a correct diagnosis was between 64.4% and 85.6% with a confidence interval of 95%. A higher accuracy rate was obtained when the skin lesion occurred on the face or when its border was categorized as poorly demarcated. Conclusions. This study demonstrates the implementation of a teledermatology strategy based on mobile applications and domain ontology-driven knowledge base to provide timely assistance to healthcare professionals. This approach was found to be pertinent in the Colombian rural context, particularly in forest regions, where dermatology specialists are not available. The results of this article do not represent a final validation of the proposed approach; they suggest how the ontology can be improved to effectively support medical staff in marginalized regions.

Fluorescence lifetime spectroscopy: a new technique for the characterization of polyplexes

2014 ◽  
Author(s):  
Cosimo D’Andrea ◽  
Daniele Pezzoli ◽  
Chiara Malloggi ◽  
Alessia Candeo ◽  
Alessandro Volonterio ◽  
...  
Keyword(s):  
Fluorescence Lifetime ◽  
New Technique ◽  
A New Technique

scholarly journals Characterization of Raman Spectroscopy System Transfer Functions in Intensity, Wavelength, and Time

Instruments ◽  
2020 ◽  
Vol 4 (3) ◽  
pp. 22
Author(s):  
Yu-Chung Lin ◽  
Joseph V. Sinfield
Keyword(s):  
Transfer Function ◽  
Transfer Functions ◽  
Low Cost ◽  
Instrument Design ◽  
Spectroscopic Techniques ◽  
Measurement Science ◽  
Broad Array ◽  
Spectroscopy System ◽  
System Transfer Function

The emergence of a wide variety of relatively low-cost compact spectrometers has led to an increase in the use of spectroscopic techniques by researchers in a broad array of fields beyond those that have traditionally employed these analytical methods. While the fundamental elements and functions of Raman systems are generally consistent, the specific components that compose a system may vary in number, design, and configuration, and researchers often modify off-the-shelf spectrometers for unique applications. Understanding the effect of instrument design and components on acquired information is thus crucial and provides the prospect to optimize the system to individual needs and to properly compare results obtained with different systems while also reducing the potential for unintended misinterpretation of data. This paper provides a practical treatment of the influences in a typical compact spectroscopy system that can impact the extent to which the output of the system is representative of the observed environment, a relationship that in measurement science is classically termed the system transfer function. For clarity, the transfer function is developed in terms of traditional Raman output parameters, namely intensity, wavelength, and time.

scholarly journals Isolation and Characterization of Akhmeta Virus from Wild-Caught Rodents (Apodemus spp.) in Georgia

2019 ◽  
Vol 93 (24) ◽  
Author(s):  
Jeffrey B. Doty ◽  
Giorgi Maghlakelidze ◽  
Irakli Sikharulidze ◽  
Shin-Lin Tu ◽  
Clint N. Morgan ◽  
...  
Keyword(s):  
Natural History ◽  
Molecular Characterization ◽  
Small Mammals ◽  
Skin Lesions ◽  
Human Populations ◽  
Content Type ◽  
Subsequent Investigation ◽  
Isolation And Characterization ◽  
History Of

ABSTRACT In 2013, a novel orthopoxvirus was detected in skin lesions of two cattle herders from the Kakheti region of Georgia (country); this virus was named Akhmeta virus. Subsequent investigation of these cases revealed that small mammals in the area had serological evidence of orthopoxvirus infections, suggesting their involvement in the maintenance of these viruses in nature. In October 2015, we began a longitudinal study assessing the natural history of orthopoxviruses in Georgia. As part of this effort, we trapped small mammals near Akhmeta (n = 176) and Gudauri (n = 110). Here, we describe the isolation and molecular characterization of Akhmeta virus from lesion material and pooled heart and lung samples collected from five wood mice (Apodemus uralensis and Apodemus flavicollis) in these two locations. The genomes of Akhmeta virus obtained from rodents group into 2 clades: one clade represented by viruses isolated from A. uralensis samples, and one clade represented by viruses isolated from A. flavicollis samples. These genomes also display several presumptive recombination events for which gene truncation and identity have been examined. IMPORTANCE Akhmeta virus is a unique Orthopoxvirus that was described in 2013 from the country of Georgia. This paper presents the first isolation of this virus from small mammal (Rodentia; Apodemus spp.) samples and the molecular characterization of those isolates. The identification of the virus in small mammals is an essential component to understanding the natural history of this virus and its transmission to human populations and could guide public health interventions in Georgia. Akhmeta virus genomes harbor evidence suggestive of recombination with a variety of other orthopoxviruses; this has implications for the evolution of orthopoxviruses, their ability to infect mammalian hosts, and their ability to adapt to novel host species.

Coating Thickness Characterization of Composite Materials Using Terahertz Waves

2016 ◽  
Vol 878 ◽  
pp. 70-73 ◽  
Author(s):  
Kwang Hee Im ◽  
Sun Kyu Kim ◽  
David K. Hsu ◽  
Jong An Jung
Keyword(s):  
Refractive Index ◽  
Coating Thickness ◽  
Composite Laminates ◽  
Electromagnetic Properties ◽  
Terahertz Waves ◽  
Reflection Mode ◽  
Cfrp Composite ◽  
Spectroscopy System ◽  
Terahertz Ray

Recently, terahertz ray imaging has emerged as one of the most promising new powerful nondestructive evaluation (NDE) techniques for the area applications. In this study, a new time-domain spectroscopy system was utilized for measuring the coating thickness on CFRP composite laminates. Extensive experimental measurements in reflection mode were made to map out the T-ray images. Also, the refractive index was estimated based on the electromagnetic properties. The CFRP composite laminates were observed in reflection mode and limitations will be discussed in the T-ray processing. By using these characterized material properties, the characteristics was successfully demonstrated for T-ray behavior propagating through the Shim Stock films for acquiring the refractive index. The T-ray technique has been developed for the measurement of the thickness of the Shim Stock films and the coating thickness on CFRP composites. Good results have been obtained in tests made on the thickness of the standard film samples with the coating thickness ranging from around hundreds of μm.

scholarly journals Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques

2011 ◽  
Vol 16 (9) ◽  
pp. 096018 ◽  
Author(s):  
Jennifer Phipps ◽  
Yinghua Sun ◽  
Ramez Saroufeem ◽  
Nisa Hatami ◽  
Michael C. Fishbein ◽  
...  
Keyword(s):  
Fluorescence Lifetime ◽  
Biochemical Composition ◽  
Atherosclerotic Plaques ◽  
Fluorescence Lifetime Imaging ◽  
Lifetime Imaging
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