Accelerated iterative image reconstruction in three-dimensional optoacoustic tomography

2015 ◽  
Author(s):  
Fatima Anis ◽  
Kun Wang ◽  
Richard Su ◽  
Sergey A. Ermilov ◽  
Alexander A. Oraevsky ◽  
...  
2020 ◽  
Vol 93 (1110) ◽  
pp. 20190675
Author(s):  
Takuya Ishikawa ◽  
Shigeru Suzuki ◽  
Yoshiaki Katada ◽  
Tomoko Takayanagi ◽  
Rika Fukui ◽  
...  

Objective: The purpose of this study was to evaluate the image quality in virtual monochromatic imaging (VMI) at 40 kilo-electron volts (keV) with three-dimensional iterative image reconstruction (3D-IIR). Methods: A phantom study and clinical study (31 patients) were performed with dual-energy CT (DECT). VMI at 40 keV was obtained and the images were reconstructed using filtered back projection (FBP), 50% adaptive statistical iterative reconstruction (ASiR), and 3D-IIR. We conducted subjective and objective evaluations of the image quality with each reconstruction technique. Results: The image contrast-to-noise ratio and image noise in both the clinical and phantom studies were significantly better with 3D-IIR than with 50% ASiR, and with 50% ASiR than with FBP (all, p < 0.05). The standard deviation and noise power spectra of the reconstructed images decreased in the order of 3D-IIR to 50% ASiR to FBP, while the modulation transfer function was maintained across the three reconstruction techniques. In most subjective evaluations in the clinical study, the image quality was significantly better with 3D-IIR than with 50% ASiR, and with 50% ASiR than with FBP (all, p < 0.001). Regarding the diagnostic acceptability, all images using 3D-IIR were evaluated as being fully or probably acceptable. Conclusions: The quality of VMI at 40 keV is improved by 3D-IIR, which allows the image noise to be reduced and structural details to be maintained. Advances in knowledge: The improvement of the image quality of VMI at 40 keV by 3D-IIR may increase the subjective acceptance in the clinical setting.


Medicine ◽  
2019 ◽  
Vol 98 (13) ◽  
pp. e14947
Author(s):  
Shigeru Suzuki ◽  
Yoshiaki Katada ◽  
Tomoko Takayanagi ◽  
Haruto Sugawara ◽  
Takuya Ishikawa ◽  
...  

2013 ◽  
Vol 40 (2) ◽  
pp. 023301 ◽  
Author(s):  
Kun Wang ◽  
Chao Huang ◽  
Yu-Jiun Kao ◽  
Cheng-Ying Chou ◽  
Alexander A. Oraevsky ◽  
...  

2008 ◽  
Vol 13 (5) ◽  
pp. 054052 ◽  
Author(s):  
Pinhas Ephrat ◽  
Lynn Keenliside ◽  
Adam Seabrook ◽  
Frank S. Prato ◽  
Jeffrey J. L. Carson

2012 ◽  
Author(s):  
Kun Wang ◽  
Richard Su ◽  
Alexander A. Oraevsky ◽  
Mark A. Anastasio

Author(s):  
R. A. Crowther

The reconstruction of a three-dimensional image of a specimen from a set of electron micrographs reduces, under certain assumptions about the imaging process in the microscope, to the mathematical problem of reconstructing a density distribution from a set of its plane projections.In the absence of noise we can formulate a purely geometrical criterion, which, for a general object, fixes the resolution attainable from a given finite number of views in terms of the size of the object. For simplicity we take the ideal case of projections collected by a series of m equally spaced tilts about a single axis.


Author(s):  
Santosh Bhattacharyya

Three dimensional microscopic structures play an important role in the understanding of various biological and physiological phenomena. Structural details of neurons, such as the density, caliber and volumes of dendrites, are important in understanding physiological and pathological functioning of nervous systems. Even so, many of the widely used stains in biology and neurophysiology are absorbing stains, such as horseradish peroxidase (HRP), and yet most of the iterative, constrained 3D optical image reconstruction research has concentrated on fluorescence microscopy. It is clear that iterative, constrained 3D image reconstruction methodologies are needed for transmitted light brightfield (TLB) imaging as well. One of the difficulties in doing so, in the past, has been in determining the point spread function of the system.We have been developing several variations of iterative, constrained image reconstruction algorithms for TLB imaging. Some of our early testing with one of them was reported previously. These algorithms are based on a linearized model of TLB imaging.


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