Phantom studies with gold nanorods as contrast agents for photoacoustic imaging: novel and old approaches

2015 ◽  
Author(s):  
Cinzia Avigo ◽  
Nicole Di Lascio ◽  
Paolo Armanetti ◽  
Francesco Stea ◽  
Lucia Cavigli ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Phantom Studies

scholarly journals Gold nanorods as molecular contrast agents in photoacoustic imaging: the promises and the caveats

2011 ◽  
Vol 6 (5) ◽  
pp. 389-400 ◽  
Author(s):  
Srirang Manohar ◽  
Constantin Ungureanu ◽  
Ton G. Van Leeuwen
Keyword(s):  
Contrast Agents ◽  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Molecular Contrast

scholarly journals Gold nanorods: contrast agents for photoacoustic imaging?

2007 ◽  
Author(s):  
C. Ungureanu ◽  
R. Raja Gopal ◽  
T. G. van Leeuwen ◽  
S. Manohar
Keyword(s):  
Contrast Agents ◽  
Gold Nanorods ◽  
Photoacoustic Imaging

scholarly journals Photostability of Contrast Agents for Photoacoustics: The Case of Gold Nanorods

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 116
Author(s):  
Lucia Cavigli ◽  
Boris N. Khlebtsov ◽  
Sonia Centi ◽  
Nikolai G. Khlebtsov ◽  
Roberto Pini ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Practical Interest ◽  
Interfacial Thermal Resistance ◽  
Optical Pulses ◽  
Initial Shape ◽  
Photothermal Ablation ◽  
Main Ideas

Plasmonic particles as gold nanorods have emerged as powerful contrast agents for critical applications as the photoacoustic imaging and photothermal ablation of cancer. However, their unique efficiency of photothermal conversion may turn into a practical disadvantage, and expose them to the risk of overheating and irreversible photodamage. Here, we outline the main ideas behind the technology of photoacoustic imaging and the use of relevant contrast agents, with a main focus on gold nanorods. We delve into the processes of premelting and reshaping of gold nanorods under illumination with optical pulses of a typical duration in the order of few ns, and we present different approaches to mitigate this issue. We undertake a retrospective classification of such approaches according to their underlying, often implicit, principles as: constraining the initial shape; or speeding up their thermal coupling to the environment by lowering their interfacial thermal resistance; or redistributing the input energy among more particles. We discuss advantages, disadvantages and contexts of practical interest where one solution may be more appropriate than the other.

scholarly journals Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging

Biomaterials ◽  
2016 ◽  
Vol 102 ◽  
pp. 87-97 ◽  
Author(s):  
Rabee Cheheltani ◽  
Rami M. Ezzibdeh ◽  
Peter Chhour ◽  
Kumidini Pulaparthi ◽  
Johoon Kim ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Photoacoustic Imaging

scholarly journals Gold nanocages as contrast agents for photoacoustic imaging

2011 ◽  
Vol 6 (5) ◽  
pp. 370-377 ◽  
Author(s):  
Weiyang Li ◽  
Paige K. Brown ◽  
Lihong V. Wang ◽  
Younan Xia
Keyword(s):  
Contrast Agents ◽  
Photoacoustic Imaging ◽  
Gold Nanocages

Polymeric/Inorganic Multifunctional Nanoparticles for Simultaneous Drug Delivery and Visualization

2010 ◽  
Vol 1257 ◽  
Author(s):  
Andrea Fornara ◽  
Alberto Recalenda ◽  
Jian Qin ◽  
Abhilash Sugunan ◽  
Fei Ye ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Microscopy ◽  
Contrast Agents ◽  
Gold Nanorods ◽  
In Vitro Cytotoxicity ◽  
In Vivo Studies ◽  
Multifunctional Nanoparticles ◽  
Cytotoxicity Studies

AbstractNanoparticles consisting of different biocompatible materials are attracting a lot of interest in the biomedical area as useful tools for drug delivery, photo-therapy and contrast enhancement agents in MRI, fluorescence and confocal microscopy. This work mainly focuses on the synthesis of polymeric/inorganic multifunctional nanoparticles (PIMN) based on biocompatible di-block copolymer poly(L,L-lactide-co-ethylene glycol) (PLLA-PEG) via an emulsion-evaporation method. Besides containing a hydrophobic drug (Indomethacin), these polymeric nanoparticles incorporate different visualization agents such as superparamagnetic iron oxide nanoparticles (SPION) and fluorescent Quantum Dots (QDs) that are used as contrast agents for Magnetic Resonance Imaging (MRI) and fluorescence microscopy together. Gold Nanorods are also incorporated in such nanostructures to allow simultaneous visualization and photodynamic therapy. MRI studies are performed with different loading of SPION into PIMN, showing an enhancement in T2 contrast superior to commercial contrast agents. Core-shell QDs absorption and emission spectra are recorded before and after their loading into PIMN. With these polymeric/inorganic multifunctional nanoparticles, both MRI visualization and confocal fluorescence microscopy studies can be performed. Gold nanorods are also synthesized and incorporated into PIMN without changing their longitudinal absorption peak usable for lased excitation and phototherapy. In-vitro cytotoxicity studies have also been performed to confirm the low cytotoxicity of PIMN for further in-vivo studies.

scholarly journals Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia

RSC Advances ◽  
2019 ◽  
Vol 9 (29) ◽  
pp. 16863-16868 ◽  
Author(s):  
Yui Umehara ◽  
Toki Kageyama ◽  
Aoi Son ◽  
Yu Kimura ◽  
Teruyuki Kondo ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Tumor Hypoxia ◽  
Biological Reduction ◽  
Selective Accumulation ◽  
Tumor Selective

Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging.

scholarly journals Croconaine‐Based Polymer Particles as Contrast Agents for Photoacoustic Imaging

2020 ◽  
Vol 41 (22) ◽  
pp. 2000418
Author(s):  
Felicitas Jansen ◽  
Markus Lamla ◽  
Diana Mauthe ◽  
Stephan Fischer ◽  
Holger Barth ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Photoacoustic Imaging ◽  
Polymer Particles
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