scholarly journals Molecular Fluorescence and Photoacoustic Imaging in the Second Near‐Infrared Optical Window Using Organic Contrast Agents

2018 ◽  
Vol 2 (5) ◽  
pp. 1700262 ◽  
Author(s):  
Yuyan Jiang ◽  
Kanyi Pu
Keyword(s):  
Contrast Agents ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Optical Window ◽  
Molecular Fluorescence

scholarly journals CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES

2014 ◽  
Vol 07 (01) ◽  
pp. 1350029 ◽  
Author(s):  
JUNPING ZHONG ◽  
SIHUA YANG
Keyword(s):  
Indocyanine Green ◽  
Contrast Agents ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Signal Amplitude ◽  
Photoacoustic Signal ◽  
Infrared Wavelength ◽  
Contrast Enhanced ◽  
Human Use ◽  
Good Contrast

Contrast agents are attracting a great deal of attention in photoacoustic imaging. Here we introduce an exogenous contrast agent that provides high photoacoustic signal amplitude at the near-infrared wavelength. Our agents consist of Indocyanine green (ICG) and phospholipid–polyethylene glycol (PL–PEG), entitled ICG–PL–PEG nanoparticles. These nanoparticles have overcome numerous limitations of ICG, such as poor aqueous stability, concentration-dependent aggregation and lack of target specificity. ICG–PL–PEG nanoparticles are biocompatible and relatively nontoxic. All the components of ICG–PL–PEG nanoparticles have been approved for human use. Upon pulsed laser irradiation, the nanoparticles are more efficient in producing photoacoustic waves than ICG alone. The results showed that ICG–PL–PEG nanoparticles act as good contrast agents for photoacoustic imaging. These unique ICG–PL–PEG nanoparticles have great potential in clinical applications.

Nanomaterials for photoacoustic imaging in the second near-infrared window

2019 ◽  
Vol 7 (2) ◽  
pp. 472-479 ◽  
Author(s):  
Kai Huang ◽  
Yifan Zhang ◽  
Jing Lin ◽  
Peng Huang
Keyword(s):  
Contrast Agents ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Tissue Penetration ◽  
Imaging Quality ◽  
Enhanced Imaging ◽  
Infrared Window

The use of nanomaterials as contrast agents for photoacoustic imaging in the NIR-II window enables enhanced imaging quality with deeper tissue penetration.

Push–pull type meso-ester substituted BODIPY near-infrared dyes as contrast agents for photoacoustic imaging

2017 ◽  
Vol 15 (21) ◽  
pp. 4531-4535 ◽  
Author(s):  
Yong Ni ◽  
Ravi Kumar Kannadorai ◽  
Sidney W.-K. Yu ◽  
Young-Tae Chang ◽  
Jishan Wu
Keyword(s):  
Contrast Agents ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Nir Absorption ◽  
Photo Stability

Push–pull meso-ester BODIPYs with intense NIR absorption and good photo-stability were used for in vitro and in vivo photoacoustic imaging.

scholarly journals Evaluating the Targeting Efficiency of Anti-EGFR Functionalised Nanoparticles to Head and Neck Cancer Cells for Use in NIR-II Optical Window

2021 ◽  
Author(s):  
Teklu Egnuni ◽  
Nicola Ingram ◽  
P. Louise Coletta ◽  
James R. McLaughlan
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Growth Factor Receptor ◽  
Optical Window ◽  
Targeting Efficiency ◽  
Optical Attenuation ◽  
Significant Difference

Gold nanoparticles have been indicated for use in a diagnostic and/or therapeutic role in several cancer types. The use of gold nanorods (AuNRs) with a surface plasmon resonance (SPR) in the second Near-Infrared II (NIR-II) optical window promises deeper anatomical penetration through increased maximum permissible exposure and lower optical attenuation. In this study, the targeting efficiency of anti-epidermal growth factor receptor (EGFR) antibody functionalised AuNRs with an SPR at 1064 nm was evaluated in vitro. Four cell lines, KYSE-30, CAL-27, Hep-G2 and MCF-7 that either over or under expressed EGFR were used. This expression was confirmed by flow cytometry and immunofluorescence. Cytotoxicity assays showed no AuNRs toxicity to both EGFR positive and EGFR negative cell lines up to a concentrations of 19 µg/ml. Optical microscopy demonstrated a significant difference (p<0.0001) between targeted AuNRs (tAuNRs) and untargeted AuNRs (uAuNRs) in all four cancer cell lines. This study demonstrates that anti-EGFR functionalisation significantly increased the number of tAuNRs associated with each EGFR positive cancer cell. This successful targeting highlights the use of tAuNRs for molecular photoacoustic imaging or tumour treatment through plasmonic photothermal therapy.

Pyrazino[2,3-g]quinoxaline-Based Nanoparticles as Near-Infrared Phototheranostic Agents for Efficient Photoacoustic-Imaging-Guided Photothermal Therapy

2021 ◽  
Vol 4 (2) ◽  
pp. 2019-2029
Author(s):  
Li-Peng Zhang ◽  
Lin Kang ◽  
Xianqiang Li ◽  
Shiyang Liu ◽  
Tianlong Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

Ambient Oxygen-Doped Conjugated Polymer for pH-Activatable Aggregation-Enhanced Photoacoustic Imaging in the Second Near-Infrared Window

2021 ◽  
Vol 93 (6) ◽  
pp. 3189-3195
Author(s):  
Jiayingzi Wu ◽  
Liyan You ◽  
Saadia T. Chaudhry ◽  
Jiazhi He ◽  
Ji-Xin Cheng ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Ambient Oxygen ◽  
Infrared Window

scholarly journals Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging

Biomaterials ◽  
2016 ◽  
Vol 102 ◽  
pp. 87-97 ◽  
Author(s):  
Rabee Cheheltani ◽  
Rami M. Ezzibdeh ◽  
Peter Chhour ◽  
Kumidini Pulaparthi ◽  
Johoon Kim ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Photoacoustic Imaging
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