A force measurement instrument for optical tweezers based on the detection of light momentum changes

2014 ◽  
Author(s):  
Arnau Farré ◽  
Ferran Marsà ◽  
Mario Montes-Usategui
2016 ◽  
Vol 34 (1) ◽  
pp. 38 ◽  
Author(s):  
Sławomir Drobczyński ◽  
Kamila Duś-szachniewicz

1989 ◽  
Vol 13 (4) ◽  
pp. 220-221 ◽  
Author(s):  
W. Richardson ◽  
D. C. Smith ◽  
A. L. Evans ◽  
G. S. Anthony

2020 ◽  
Author(s):  
Kumiko Hayashi ◽  
Miki G. Miyamoto ◽  
Shinsuke Niwa

AbstractSynaptic cargo transport by kinesin and dynein in hippocampal neurons was investigated using non-invasive measurements of transport force based on non-equilibrium statistical mechanics. Although direct physical measurements such as force measurement using optical tweezers are difficult in an intracellular environment, the non-invasive estimations enabled enumerating force producing units (FPUs) carrying a cargo comprising the motor proteins generating force. The number of FPUs served as a barometer for stable and long-distance transport by multiple motors, which was then used to quantify the extent of damage to axonal transport by dynarrestin, a dynein inhibitor. We found that dynarrestin decreased the FPU for retrograde transport more than anterograde transport. In the future, these measurements may be used to quantify the damage to axonal transport resulting from neuronal diseases including Alzheimer’s, Parkinson’s, and Huntington’s diseases.


2016 ◽  
Vol 34 (1) ◽  
pp. 2693
Author(s):  
Sławomir Drobczyński ◽  
Kamila Duś-szachniewicz

2018 ◽  
Vol 3 (3) ◽  
pp. 2473011418S0039 ◽  
Author(s):  
Megan Reilly ◽  
Kurosh Darvish ◽  
Soroush Assari ◽  
John Cole ◽  
Eric Gokcen

Category: Lesser Toes Introduction/Purpose: Outcomes of the surgical treatment of dislocated lesser toes have improved significantly over the past few years due to the development of techniques to repair plantar plate tears through a dorsal incision. However, treatment of stage 4 tears with no reparable plantar plate can be challenging. The current treatment involves flexor to extensor tendon transfer, requiring multiple incisions and surgical time. An alternative approach is presented, using the same modern techniques of plantar plate repair, but reconstructing the plantar plate using a flexor tendon tenodesis to the plantar base of the proximal phalanx. Methods: Four fresh frozen cadaver foot and ankle specimens were used to determine the stability of this new technique. A simulated Lachman’s test was performed on the 2nd, 3 rd, and 4th metatarsophalangeal joints utilizing a force measurement instrument with displacement control on specimens with an intact plantar plate, an excised plantar plate, and following a flexor tenodesis reconstruction. Results: The intact plantar plate force was 9.0+2.6kN for 2 mm displacement, and following excision of the plantar plate, the force reduced to 1.3+0.4kN. The flexor tenodesis reconstruction improved the force to 6.0+1.9kN. Conclusion: Plantar plate reconstruction with a flexor tenodesis to the proximal phalanx resulted in stability equal to 53% of the intact plantar plate, for the shear displacements between 2 to 6 mm. This procedure may be an alternative treatment option in patients with Stage 4 irreparable plantar plate tears.


2012 ◽  
Vol 529 ◽  
pp. 318-321
Author(s):  
Yong Qing Ma ◽  
Ming Qing Wu

Cutting force measurement system by force measurement instrument, general data collection system and PC of three parts. The size of the cutting force general use have experimental results set up experience formula. Introduces two kinds of accurate measurement method of cutting force. Choose DEWESoft data collection and analysis system software as research means of cutting force. Through technical analysis and cutting force measurement technology development direction was predicted.


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