scholarly journals The power of hybrid / fusion imaging metrics in future PACS systems: a case study into the white matter hyperintensity prenumbra using FLAIR and diffusion MR

2014 ◽  
Author(s):  
Sinchai Tsao ◽  
Samantha J. Ma ◽  
Peter A. Michels ◽  
Niharika Gajawelli ◽  
Meng Law ◽  
...  
Keyword(s):  
White Matter ◽  
Fusion Imaging ◽  
White Matter Hyperintensity ◽  
Diffusion Mr ◽  
And Diffusion ◽  
Hybrid Fusion

scholarly journals Can post-mortem MRI be used as a proxy for in vivo? A case study

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Baayla D C Boon ◽  
Petra J W Pouwels ◽  
Laura E Jonkman ◽  
Matthijs J Keijzer ◽  
Paolo Preziosa ◽  
...  
Keyword(s):  
White Matter ◽  
Rating Scales ◽  
Brain Volume ◽  
Brain Mri ◽  
Post Mortem ◽  
Early Onset Alzheimer’S Disease ◽  
And Diffusion

Abstract Post-mortem in situ MRI has been used as an intermediate between brain histo(patho)logy and in vivo imaging. However, it is not known how comparable post-mortem in situ is to ante-mortem imaging. We report the unique situation of a patient with familial early-onset Alzheimer’s disease due to a PSEN1 mutation, who underwent ante-mortem brain MRI and post-mortem in situ imaging only 4 days apart. T1-weighted and diffusion MRI was performed at 3-Tesla at both time points. Visual atrophy rating scales, brain volume, cortical thickness and diffusion measures were derived from both scans and compared. Post-mortem visual atrophy scores decreased 0.5–1 point compared with ante-mortem, indicating an increase in brain volume. This was confirmed by quantitative analysis; showing a 27% decrease of ventricular and 7% increase of whole-brain volume. This increase was more pronounced in the cerebellum and supratentorial white matter than in grey matter. Furthermore, axial and radial diffusivity decreased up to 60% post-mortem whereas average fractional anisotropy of white matter increased approximately 10%. This unique case study shows that the process of dying affects several imaging markers. These changes need to be taken into account when interpreting post-mortem MRI to make inferences on the in vivo situation.

scholarly journals Interaction of Age and Self-reported Physical Sports Activity on White Matter Hyperintensity Volume in Healthy Older Adults

2020 ◽  
Vol 12 ◽  
Author(s):  
Mary Kathryn Franchetti ◽  
Pradyumna K. Bharadwaj ◽  
Lauren A. Nguyen ◽  
Emily J. Van Etten ◽  
Yann C. Klimentidis ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
White Matter Hyperintensity ◽  
Sports Activity ◽  
Healthy Older Adults
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