Increased White Matter Hyperintensity and Impact on Executive Function in Suicide Attempters with Late-Life Depression

2020 ◽  
Author(s):  
Chemin Lin ◽  
Huang Chih-Mao ◽  
Helmet Karim ◽  
Ho-Ling Liu ◽  
Tatia M.C. Lee ◽  
...  
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Late Life ◽  
White Matter Hyperintensity ◽  
Late Life Depression ◽  
Suicide Attempters

scholarly journals White Matter Hyperintensity Accumulation During Treatment of Late-Life Depression

2015 ◽  
Vol 40 (13) ◽  
pp. 3027-3035 ◽  
Author(s):  
Alexander Khalaf ◽  
Kathryn Edelman ◽  
Dana Tudorascu ◽  
Carmen Andreescu ◽  
Charles F Reynolds ◽  
...  
Keyword(s):  
White Matter ◽  
Late Life ◽  
White Matter Hyperintensity ◽  
Late Life Depression

scholarly journals White Matter Hyperintensity Progression and Late-Life Depression Outcomes

2003 ◽  
Vol 60 (11) ◽  
pp. 1090 ◽  
Author(s):  
Warren D. Taylor ◽  
David C. Steffens ◽  
James R. MacFall ◽  
Douglas R. McQuoid ◽  
Martha E. Payne ◽  
...  
Keyword(s):  
White Matter ◽  
Late Life ◽  
White Matter Hyperintensity ◽  
Late Life Depression

scholarly journals 348 - Increased White Matter Hyperintensity and Brain Resting-state fMRI Topology Changes in Suicide Attempters of Late-life Depression

2020 ◽  
Vol 32 (S1) ◽  
pp. 111-112
Author(s):  
Chemin Lin ◽  
Chih-Mao Huang ◽  
Ho-Ling Anthony Liu ◽  
Changwei W. Wu ◽  
Cheng Hong Toh ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Resting State ◽  
Suicide Attempts ◽  
Late Life ◽  
Resting State Fmri ◽  
White Matter Hyperintensity ◽  
Late Life Depression ◽  
Suicide Attempters ◽  
Topology Changes ◽  
History Of

Supported by (1) medical research grants CMRPG3C0041/42 from Chang Gung Memorial Hospital and NRRPG2H0031 from Ministry of Science and Technology, Taiwan to Chemin Lin (2) NMRPG3G6031/32 from Ministry of Science and Technology, Taiwan to Shwu-Hua, Lee (3) the KKHo International Charitable Foundation to Tatia Lee.Introduction:Suicide rate tends to peak in old age, and major depression is the most salient risk factor for late-life suicide. However, few studies have focused on the neuroscientific facet of suicide in the context of late-life depression (LLD).Methods:We recruited 114 participants of LLD (28 with history of suicide attempt and 86 without) and 47 elderly controls. They received MRI scanning and behavioral assessment. White matter hyperintensity (WMH) was quantified by an automated segmentation algorithm and graph theoretical analysis was applied to resting-state fMRI. We used ANCOVA to compare group difference in WMH loading and multivariate generalized linear model to compare global and local topological parameters in fMRI signals, controlling for demographics. Partial correlation was conducted between imaging parameters and behavioral data in group of suicide attempters.Results:We found significant higher WMH in suicide attempters than those of LLD without suicide attempts and elderly controls (F =7.091; p = 0.001). Suicide attempters also had increased betweenness centrality (BC) in right superior occipital gyrus (SOG) (Bonferroni corrected), right precuneus (False positive corrected) and right superior temporal gyrus (uncorrected) and decreased BC in left hippocampus (uncorrected). In suicide attempters, higher BC in right SOG correlated with higher WMH, higher depression severity, higher illness awareness and insight, and lower cognitive function (digit backward), while higher BC in right precuneus correlated with higher decrease awareness and insight and higher cognitive function (digit backward).Conclusion:Resonating with the vascular hypothesis in LLD, higher WMH was found in those having history of suicide attempts. However, the re-organized brain topology changes are related with divergent cognitive function and convergent heightened disease insight.

scholarly journals White-matter tract integrity in late-life depression: associations with severity and cognition

2013 ◽  
Vol 44 (7) ◽  
pp. 1427-1437 ◽  
Author(s):  
R. A. Charlton ◽  
M. Lamar ◽  
A. Zhang ◽  
S. Yang ◽  
O. Ajilore ◽  
...  
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Learning And Memory ◽  
Late Life ◽  
White Matter Integrity ◽  
White Matter Tract ◽  
Uncinate Fasciculus ◽  
Depression Severity ◽  
Late Life Depression ◽  
White Matter Tracts

BackgroundAlthough significant changes in both gray and white matter have been noted in late-life depression (LLD), the pathophysiology of implicated white-matter tracts has not been fully described. In this study we examined the integrity of specific white-matter tracts in LLD versus healthy controls (HC).MethodParticipants aged ⩾60 years were recruited from the community. The sample included 23 clinically diagnosed individuals with LLD and 23 HC. White-matter integrity metrics [fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD)] were calculated in the bilateral cingulum and uncinate fasciculus. Depression severity was measured using the Center for Epidemiological Studies Depression Scale (CESD). Composite scores for learning and memory and executive function were created using standardized neuropsychological assessments.ResultsWhite-matter integrity was lower in LLD versus HC in the bilateral cingulum and right uncinate fasciculus (p⩽0.05). In the whole sample, depression severity correlated with integrity in the bilateral cingulum and right uncinate fasciculus (p ⩽0.05). In patients, depression severity correlated with the integrity of the left uncinate fasciculus (p = 0.03); this tract also correlated with executive function (p = 0.02). Among HC, tract integrity did not correlate with depression scores; however, learning and memory correlated with integrity of the bilateral uncinate fasciculus and bilateral cingulum; executive function correlated with the right uncinate and left cingulum (p ⩽0.05).ConclusionsWhite-matter tract integrity was lower in LLD than in HC and was associated with depression severity across all participants. Tract integrity was associated with cognition in both groups but more robustly among HC.

033 The effect of sleep disturbance on cognition in late-life depression

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A15-A15
Author(s):  
Andrea Ricciardiello ◽  
Sharon Naismith ◽  
Angela D’Rozario ◽  
Fiona Kumfor ◽  
Rick Wassing
Keyword(s):  
Executive Function ◽  
Sleep Disturbance ◽  
Slow Wave ◽  
Cognitive Deficits ◽  
Memory Performance ◽  
Verbal Learning ◽  
Late Life ◽  
Control Group ◽  
Sleep Spindles ◽  
Late Life Depression

Abstract Introduction Late-life depression is the most common psychiatric disorder in older adults and is associated with cognitive deficits, however, the role of sleep disturbance in cognitive deficits is poorly defined. In the current study we aimed to examine sleep macro and micro-architecture differences between those with late-life depression and controls. Secondly, we sought to determine how sleep changes relate to clinical memory and executive function measures in those with late-life depression and controls. Methods Using prior clinical data, this retrospective study assessed adults >50 years who had completed an overnight PSG study and comprehensive psychiatric, neuropsychological, and medical assessment. Memory performance was measured using the Weschler Memory Scale logical Memory 1 and 2 components, Rey Auditory Verbal Learning Test (Senior) 30-minute recall and Rey Complex Figure 3-minute recall. Executive function was defined by z scores from Trail Making Test, D-KEFS Stroop Test and Controlled Oral Word Association Test. The sample comprised of 71 depressed participants, defined by a Geriatric Depression Scale score ≥6, and 101 non-depressed participants (GDS <6 and no lifetime history of depression using DSM-IV criteria). Results Contrary to our hypothesis no significant macroarchitectural differences were observed between the groups. Less time spent in slow-wave sleep (SWS) was associated with worse delayed memory recall scores in the depression group (z=.342, p=0.008) although this was not seen in the control group. SWS and slow wave activity (SWA) were not related to measures of executive function performance. Depressed participants demonstrated a reduced level of sleep spindles (Dep= 159 ±142.8, con= 213±163, p=.03) although there were no associations with memory outcomes. Conclusion Compared to younger adults with depression, macroarchitectural differences in those with late-life depression are not as pronounced, due to a reduction of SWS and SWA power as a function of ageing. The efficiency of SWS hippocampal dependent memory processes in depression may be reduced, therefore, more time spent in SWS is related to better memory performance. This study assessed the density of sleep spindles but not spindle and slow wave oscillation coupling which may be more important for hippocampal dependent memory. Support (if any):

scholarly journals Vascular lesions and functional limitations among older adults: does depression make a difference?

2014 ◽  
Vol 26 (9) ◽  
pp. 1501-1509 ◽  
Author(s):  
Celia F. Hybels ◽  
Carl F. Pieper ◽  
Lawrence R. Landerman ◽  
Martha E. Payne ◽  
David C. Steffens
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
White Matter ◽  
Functional Impairment ◽  
Functional Limitations ◽  
Late Life ◽  
Cognitive Status ◽  
Cerebral White Matter ◽  
Late Life Depression ◽  
Increased Risk

ABSTRACTBackground:The association between disability and depression is complex, with disability well established as a correlate and consequence of late life depression. Studies in community samples report that greater volumes of cerebral white matter hyperintensities (WMHs) seen on brain imaging are linked with functional impairment. These vascular changes are also associated with late life depression, but it is not known if depression is a modifier in the relationship between cerebrovascular changes and functional impairment.Methods:The study sample was 237 older adults diagnosed with major depression and 140 never depressed comparison adults, with both groups assessed at study enrollment. The dependent variable was the number of limitations in basic activities of daily living (ADL), instrumental ADLs, and mobility tasks. The independent variable was the total volume of cerebral white matter lesions or hyperintensities assessed though magnetic resonance imaging.Results:In analyses controlling for age, sex, race, high blood pressure, and cognitive status, a greater volume of WMH was positively associated with the total number of functional limitations as well as the number of mobility limitations among those older adults with late life depression but not among those never depressed, suggesting the association between WMH volume and functional status differs in the presence of late life depression.Conclusions:These findings suggest older patients with both depression and vascular risk factors may be at an increased risk for functional decline, and may benefit from management of both cerebrovascular risk factors and depression.

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