Combining whispering gallery mode lasers and microstructured optical fibers for in-vivo biosensing applications

2013 ◽  
Author(s):  
A. François ◽  
K. J. Rowland ◽  
T. Reynolds ◽  
S. J. Nicholls ◽  
T. M. Monro
Keyword(s):  
Optical Fibers ◽  
Whispering Gallery Mode ◽  
Whispering Gallery ◽  
Microstructured Optical Fibers

scholarly journals Combining whispering gallery mode lasers and microstructured optical fibers: limitations, applications and perspectives for in-vivo biosensing

MRS Advances ◽  
2016 ◽  
Vol 1 (33) ◽  
pp. 2309-2320
Author(s):  
Alexandre François ◽  
Tess Reynolds ◽  
Nicolas Riesen ◽  
Jonathan M. M. Hall ◽  
Matthew R. Henderson ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Single Molecule ◽  
Collection Efficiency ◽  
Clinical Diagnostics ◽  
Clinical Samples ◽  
Whispering Gallery ◽  
Microstructured Optical Fibers ◽  
Sensing Applications ◽  
Sensing Platform

ABSTRACTWhispering gallery modes (WGMs) have been widely studied over the past 20 years for various applications, including biological sensing. While the WGM-based sensing approaches reported in the literature have shown tremendous performance down to single molecule detection, at present such sensing technologies are not yet mature and still have significant practical constraints that limit their use in real-world applications. Our work has focused on developing a practical, yet effective, WGM-based sensing platform capable of being used as a dip sensor for in-vivo biosensing by combining WGM fluorescent microresonators with silica Microstructured Optical Fibers (MOFs).We recently demonstrated that a suspended core MOF with a dye-doped polymer microresonator supporting WGMs positioned onto the tip of the fiber, can be used as a dip sensor. In this architecture the resonator is anchored to one of the MOF air holes, in contact with the fiber core, enabling a significant portion of the evanescent field from the fiber to overlap with the sphere and hence excite the fluorescent WGMs. This architecture allows for remote excitation and collection of the WGMs. The fiber also permits easy manipulation of the microresonator for dip sensing applications, and hence alleviates the need for a complex microfluidic interface. More importantly, it allows for an increase in both the excitation and collection efficiency compared to free space coupling, and also improves the Q factor.In this paper we present our recent results on microstructured fiber tip WGM-based sensors and show that this sensing platform can be used in clinical diagnostics, for detecting various clinically relevant biomarkers in complex clinical samples.

scholarly journals Application of WGM Resonances to the Measurement of the Temperature Increment of Ho and Ho-Yb Doped Optical Fibers Pumped at 1125 and 975 nm

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 2094
Author(s):  
Xavier Roselló-Mechó ◽  
Martina Delgado-Pinar ◽  
Yuri O. Barmenkov ◽  
Alexander V. Kir’yanov ◽  
Miguel V. Andrés
Keyword(s):  
Optical Fibers ◽  
Laser Diode ◽  
Thermal Sensitivity ◽  
Excited Level ◽  
Whispering Gallery Mode ◽  
Wavelength Shift ◽  
Whispering Gallery ◽  
Temperature Increment ◽  
Doped Fibers ◽  
Fiber Characterization

Optical fiber characterization using whispering gallery mode resonances of the fiber itself has been demonstrated to be a powerful technique. In this work, we exploit the thermal sensitivity of whispering gallery mode resonances to characterize the pump-induced temperature increment in holmium doped and holmium-ytterbium codoped optical fibers. The technique relies on the measurement of the resonances’ wavelength shift due to temperature variation as a function of the pump power. Holmium doped fibers were pumped to the second excited level 5I6 of the Ho3+ ion using a laser diode at 1125 nm and ytterbium-holmium codoped fibers to the 2F5/2 level of the Yb3+ ion by a laser diode at 975 nm. Our results demonstrate that pumping ytterbium-holmium codoped fibers at 975 nm results in dramatic thermal effects, producing a temperature increment two orders higher than that observed in holmium doped fibers pumped with a 1125 nm laser diode.

scholarly journals Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Nikita Toropov ◽  
Frank Vollmer
Keyword(s):  
Single Cell ◽  
Large Scale ◽  
Cell Tracking ◽  
Whispering Gallery Mode ◽  
Spectral Features ◽  
Whispering Gallery ◽  
Low Threshold

AbstractResearchers in the field of whispering-gallery-mode (WGM) microresonators have proposed biointegrated low-threshold WGM lasers, to enable large-scale parallel single-cell tracking and barcoding. Although the reported devices have so far been primarily investigated in model applications, most recent results represent important steps towards the development of in vivo tags and sensors that utilize the unique and narrow spectral features of miniature WGM lasers.

Evaluation of Effective Conductivity of Copper-Clad Dielectric Laminate Substrates in Millimeter-Wave Bands Using Whispering Gallery Mode Resonators

2009 ◽  
Vol E92-C (12) ◽  
pp. 1504-1511 ◽  
Author(s):  
Thi Huong TRAN ◽  
Yuanfeng SHE ◽  
Jiro HIROKAWA ◽  
Kimio SAKURAI ◽  
Yoshinori KOGAMI ◽  
...  
Keyword(s):  
Millimeter Wave ◽  
Effective Conductivity ◽  
Whispering Gallery Mode ◽  
Whispering Gallery

Fabrications and applications of fiber gratings based on microstructured optical fibers

2013 ◽  
Vol 30 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Yiping Wang ◽  
Changrui Liao ◽  
Jiangtao Zhou ◽  
Yingjie Liu ◽  
Zhengyong Li ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Fiber Gratings ◽  
Microstructured Optical Fibers
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