Assessment of noncoherent light sources for photodynamic therapy

1994 ◽  
Author(s):  
Roy H. Pottier ◽  
Eva F. Gudgin Dickson ◽  
Pierre Nadeau ◽  
Helmut Wieland ◽  
Kasimir Sosin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Sources ◽  
Noncoherent Light

Use of photodynamic therapy for photodamage skin (review of literature)

2019 ◽  
Vol 1 (7) ◽  
pp. 19-23
Author(s):  
S. I. Surkichin ◽  
N. V. Gryazeva ◽  
L. S. Kholupova ◽  
N. V. Bochkova
Keyword(s):  
Photodynamic Therapy ◽  
Comparative Evaluation ◽  
Clinical Manifestations ◽  
Light Sources ◽  
Review Of Literature ◽  
Photosensitizing Agents ◽  
Selection Of

The article provides an overview of the use of photodynamic therapy for photodamage of the skin. The causes, pathogenesis and clinical manifestations of skin photodamage are considered. The definition, principle of action of photodynamic therapy, including the sources of light used, the classification of photosensitizers and their main characteristics are given. Analyzed studies that show the effectiveness and comparative evaluation in the selection of various light sources and photosensitizing agents for photodynamic therapy in patients with clinical manifestations of photodamage.

scholarly journals The Effect of Antimicrobial Photodynamic Therapy Using Chlorophyllin–Phycocyanin Mixture on Enterococcus faecalis: The Influence of Different Light Sources

2020 ◽  
Vol 10 (12) ◽  
pp. 4290 ◽  
Author(s):  
Nasim Chiniforush ◽  
Maryam Pourhajibagher ◽  
Steven Parker ◽  
Stefano Benedicenti ◽  
Abbas Bahador ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Diode Laser ◽  
Enterococcus Faecalis ◽  
Control Group ◽  
Human Gingival Fibroblast ◽  
Light Sources ◽  
Gingival Fibroblast ◽  
Antimicrobial Photodynamic Therapy ◽  
Cell Viability Assay ◽  
Vitro Effect

The purpose of this study was to evaluate the in vitro effect of the chlorophyllin–phycocyanin mixture (Photoactive+) as a photosensitizer (PS) during antimicrobial photodynamic therapy (aPDT) on the count of Enterococcus faecalis (E. faecalis) using different light sources. The antimicrobial effect of aPDT with chlorophyllin–phycocyanin mixture using different light sources including diode laser (λ = 660 nm), diode laser (λ = 635 nm), LED (λ = 450 ± 30 nm) alone or in combination was assessed using microbial cell viability assay against E. faecalis. In addition, the cell cytotoxicity of Photoactive+ was assessed on human gingival fibroblast (HuGu) cells by MTT assay; E. faecalis growth when treated by both red wavelengths (635 nm, 660 nm) and combination of LED (420–480 nm) and red wavelengths (635 nm, 660 nm), significantly reduced compared to the control group (p < 0.05). There was no significant reduction in the number of viable cells exposed to Photoactive+ compared to the control group (p < 0.05). This study shows that the application of chlorophyllin–phycocyanin mixture and irradiation with emission of red light achieved a better result for bacterial count reduction, compared to a control. This component can be applied safely due to very negligible cytotoxicity.

scholarly journals Flexible organic light-emitting diodes for antimicrobial photodynamic therapy

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Cheng Lian ◽  
Marta Piksa ◽  
Kou Yoshida ◽  
Saydulla Persheyev ◽  
Krzysztof J. Pawlik ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Bacterial Infections ◽  
Light Emitting Diodes ◽  
High Irradiance ◽  
Organic Light Emitting Diodes ◽  
Light Sources ◽  
Driving Voltage ◽  
Light Emitting ◽  
Organic Light ◽  
Operational Lifetime

Abstract Bacterial infection and the growth of antibiotic resistance is a serious problem that leads to patient suffering, death and increased costs of healthcare. To address this problem, we propose using flexible organic light-emitting diodes (OLEDs) as light sources for photodynamic therapy (PDT) to kill bacteria. PDT involves the use of light and a photosensitizer to generate reactive oxygen species that kill neighbouring cells. We have developed flexible top-emitting OLEDs with the ability to tune the emission peak from 669 to 737 nm to match the photosensitizer, together with high irradiance, low driving voltage, long operational lifetime and adequate shelf-life. These features enable OLEDs to be the ideal candidate for ambulatory PDT light sources. A detailed study of OLED–PDT for killing Staphylococcus aureus was performed. The results show that our OLEDs in combination with the photosensitizer methylene blue, can kill more than 99% of bacteria. This indicates a huge potential for using OLEDs to treat bacterial infections.

A comparison of novel light sources for photodynamic therapy

1997 ◽  
Vol 12 (3) ◽  
pp. 260-268 ◽  
Author(s):  
M. L. De Jode ◽  
J. A. Mcgilligan ◽  
M. G. Dilkes ◽  
I. Cameron ◽  
P. B. Hart ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Sources

Performance of photodynamic therapy using multiple light sources in the rat R1 rhabdomyosarcoma tumor model

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 3192-3192
Author(s):  
M. J. Winship ◽  
H. Xu ◽  
F. C. Zheng ◽  
M. A. Krouse ◽  
B. W. McIlroy ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Model ◽  
Light Sources
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