Compact imaging system with single-photon sensitivity and picosecond time resolution for fluorescence-guided surgery with lifetime imaging capability

2013 ◽  
Author(s):  
F. Powolny ◽  
C. Bruschini ◽  
E. Dubikovskaya ◽  
E. Grigoriev ◽  
O. Michielin ◽  
...  
Keyword(s):  
Time Resolution ◽  
Imaging System ◽  
Single Photon ◽  
Imaging Capability ◽  
Lifetime Imaging ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery

Time-resolved imaging system for fluorescence-guided surgery with lifetime imaging capability

2014 ◽  
Author(s):  
F. Powolny ◽  
K. Homicsko ◽  
R. Sinisi ◽  
Claudio E. Bruschini ◽  
E. Grigoriev ◽  
...  
Keyword(s):  
Imaging System ◽  
Time Resolved ◽  
Imaging Capability ◽  
Lifetime Imaging ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Time Resolved Imaging

scholarly journals Indocyanine green matching phantom for fluorescence-guided surgery imaging system characterization and performance assessment

2020 ◽  
Vol 25 (05) ◽  
pp. 1
Author(s):  
Alberto J. Ruiz ◽  
Mindy Wu ◽  
Ethan Philip M. LaRochelle ◽  
Dimitris Gorpas ◽  
Vasilis Ntziachristos ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Performance Assessment ◽  
Imaging System ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
System Characterization ◽  
And Performance

A hand-held portable imaging system for effective fluorescence-guided surgery of a pancreatic patient-derived orthotopic xenograft (PDOX) in nude mice.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e15219-e15219
Author(s):  
Yukihiko Hiroshima ◽  
Ali Maawy ◽  
Fuminari Uehara ◽  
Shinji Miwa ◽  
Shuya Yano ◽  
...  
Keyword(s):  
Nude Mice ◽  
Imaging System ◽  
Guided Surgery ◽  
Orthotopic Xenograft ◽  
Fluorescence Guided Surgery

Influence of dexamethasone on visible 5-ALA fluorescence and quantitative protoporphyrin IX accumulation measured by fluorescence lifetime imaging in glioblastomas: is pretreatment obligatory before fluorescence-guided surgery?

2021 ◽  
pp. 1-9
Author(s):  
Lisa I. Wadiura ◽  
David Reichert ◽  
Veronika Sperl ◽  
Alexandra Lang ◽  
Barbara Kiesel ◽  
...  
Keyword(s):  
Fluorescence Lifetime ◽  
Aminolevulinic Acid ◽  
Ex Vivo ◽  
Protoporphyrin Ix ◽  
Fluorescence Lifetime Imaging ◽  
Lifetime Imaging ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Significant Difference ◽  
The Mean

OBJECTIVE Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is nowadays widely applied for improved resection of glioblastomas (GBMs). Initially, pretreatment with dexamethasone was considered to be essential for optimal fluorescence effect. However, recent studies reported comparably high rates of visible fluorescence in GBMs despite absence of dexamethasone pretreatment. Recently, the authors proposed fluorescence lifetime imaging (FLIM) for the quantitative analysis of 5-ALA–induced protoporphyrin IX (PpIX) accumulation. The aim of this study was thus to investigate the influence of dexamethasone on visible fluorescence and quantitative PpIX accumulation. METHODS The authors prospectively analyzed the presence of visible fluorescence during surgery in a cohort of patients with GBMs. In this study, patients received dexamethasone preoperatively only if clinically indicated. One representative tumor sample was collected from each GBM, and PpIX accumulation was analyzed ex vivo by FLIM. The visible fluorescence status and mean FLIM values were correlated with preoperative intake of dexamethasone. RESULTS In total, two subgroups with (n = 27) and without (n = 20) pretreatment with dexamethasone were analyzed. All patients showed visible fluorescence independent from preoperative dexamethasone intake. Furthermore, the authors did not find a statistically significant difference in the mean FLIM values between patients with and without dexamethasone pretreatment (p = 0.097). CONCLUSIONS In this first study to date, the authors found no significant influence of dexamethasone pretreatment on either visible 5-ALA fluorescence during GBM surgery or PpIX accumulation based on FLIM. According to these preliminary data, the authors recommend administering dexamethasone prior to fluorescence-guided surgery of GBMs only when clinically indicated.

scholarly journals Real-time fluorescence lifetime imaging system with a 32 × 32 013μm CMOS low dark-count single-photon avalanche diode array

2010 ◽  
Vol 18 (10) ◽  
pp. 10257 ◽  
Author(s):  
Day-Uei Li ◽  
Jochen Arlt ◽  
Justin Richardson ◽  
Richard Walker ◽  
Alex Buts ◽  
...  
Keyword(s):  
Real Time ◽  
Fluorescence Lifetime ◽  
Imaging System ◽  
Single Photon ◽  
Diode Array ◽  
Fluorescence Lifetime Imaging ◽  
Dark Count ◽  
Avalanche Diode ◽  
Lifetime Imaging

scholarly journals Electrically tunable fluidic lens imaging system for laparoscopic fluorescence-guided surgery

2017 ◽  
Vol 8 (7) ◽  
pp. 3232 ◽  
Author(s):  
Davide Volpi ◽  
Iain D. C. Tullis ◽  
Paul R. Barber ◽  
Edyta M. Augustyniak ◽  
Sean C. Smart ◽  
...  
Keyword(s):  
Imaging System ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery
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