Scanner setup and reconstruction for three-dimensional magnetic particle imaging

Author(s):  
T. Wawrzik ◽  
C. Kuhlmann ◽  
F. Ludwig ◽  
M. Schilling
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sebastian Draack ◽  
Meinhard Schilling ◽  
Thilo Viereck

Abstract Magnetic particle imaging (MPI) is a young imaging modality for biomedical applications. It uses magnetic nanoparticles as a tracer material to produce three-dimensional images of the spatial tracer distribution in the field-of-view. Since the tracer magnetization dynamics are tied to the hydrodynamic mobility via the Brownian relaxation mechanism, MPI is also capable of mapping the local environment during the imaging process. Since the influence of viscosity or temperature on the harmonic spectrum is very complicated, we used magnetic particle spectroscopy (MPS) as an integral measurement technique to investigate the relationships. We studied MPS spectra as function of both viscosity and temperature on model particle systems. With multispectral MPS, we also developed an empirical tool for treating more complex scenarios via a calibration approach. We demonstrate that MPS/MPI are powerful methods for studying particle-matrix interactions in complex media.


2015 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
I. Kuschnerus ◽  
K. Lüdtke-Buzug

AbstractSince 2005, Magnetic Particle Imaging (MPI) is handled as a key technology with great potential in medical applications as an imaging method [1]. The superparamagnetic iron oxide nanoparticles (SPIONs) which are already used as a tracer in MPI, combined with various polymers, are being investigated in order to enhance this potential. A combination of polymers such as polyethylene (PE) and polyurethane (PU) and SPIONs could be used as a coating for medical devices, or added to semi-rigid polyurethane for the production of surgical instruments [2]. This would be of great interest, since the method provides high sensitivity with simultaneous high spatial resolution and three-dimensional imaging in real time. Therefore various superparamagnetic coatings were developed, tested and characterized. Finally SPIONs and various polymers were combined directly and used for MPI-compatible models.


Nanoscale ◽  
2022 ◽  
Author(s):  
Stanley Harvell-Smith ◽  
Le Duc Tung ◽  
Nguyen Thi Kim Thanh

Magnetic particle imaging (MPI) is an emerging tracer-based modality that enables real-time three-dimensional imaging of the non-linear magnetisation produced by superparamagnetic iron oxide nanoparticles (SPIONs), in the presence of an...


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