Optical coherence tomography detection of shear wave propagation in layered tissue equivalent phantoms

2013 ◽  
Author(s):  
Marjan Razani ◽  
Adrian Mariampillai ◽  
Peter Siegler ◽  
Victor X. D. Yang ◽  
Michael C. Kolios
Keyword(s):  
Optical Coherence Tomography ◽  
Wave Propagation ◽  
Shear Wave ◽  
Optical Coherence ◽  
Tissue Equivalent

scholarly journals Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples

2014 ◽  
Vol 5 (3) ◽  
pp. 895 ◽  
Author(s):  
Marjan Razani ◽  
Timothy W.H. Luk ◽  
Adrian Mariampillai ◽  
Peter Siegler ◽  
Tim-Rasmus Kiehl ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Wave Propagation ◽  
Carotid Artery ◽  
Shear Wave ◽  
Ex Vivo ◽  
Optical Coherence ◽  
Tissue Equivalent

Optical coherence tomography detection of shear wave propagation in MCF7 cell modules

2014 ◽  
Author(s):  
Marjan Razani ◽  
Adrian Mariampillai ◽  
Elizabeth S. L. Berndl ◽  
Tim-Rasmus Kiehl ◽  
Victor X. D. Yang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Wave Propagation ◽  
Shear Wave ◽  
Mcf7 Cell ◽  
Optical Coherence ◽  
Cell Modules

scholarly journals Development of optical coherence tomography technique for clinical diagnostics and monitoring

2021 ◽  
Author(s):  
Marjan Razani
Keyword(s):  
Optical Coherence Tomography ◽  
Carotid Artery ◽  
Shear Wave ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Optical Coherence ◽  
Swept Source ◽  
Tissue Equivalent ◽  
Oct Imaging

This dissertation describes techniques that use Optical Coherence Tomography techniques developed for the detection of shear wave propagation in different phantoms, and the use of such waves to enhance the transport of nanoparticles in tissue equivalent phantoms. In the first study, we explored the potential of measuring shear wave propagation using optical co-herence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a swept source optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, syn-chronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were com-posed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. In the second study, we present a technique to image the enhanced particle displacement generated using an acoustic radiation force (ARF) excitation source. A MEMS-VCSEL swept source Optical Coherence Tomography (SS-OCT) system with a center wavelength of 1310 nm, a bandwidth of 100nm, and an A-scan rate of 100 kHz was used to detect gold nanoparticle displacement. ARF was applied after the nanoparticles diffused into a collagen matrix (of different collagen concen-trations and for a tissue engineered MCF-7 breast cancer cell construct). Differential OCT speckle variance images with and without the ARF were used to estimate the particle dis-placement. The images were used to detect the microscopic enhancement of nanoparticle displacement generated by the ARF. Using this OCT imaging technique, the enhanced transport of particles though a collagen gel after using an ARF excitation was imaged and analysed.

scholarly journals Feasibility of optical coherence elastography measurements of shear wave propagation in homogeneous tissue equivalent phantoms

2012 ◽  
Vol 3 (5) ◽  
pp. 972 ◽  
Author(s):  
Marjan Razani ◽  
Adrian Mariampillai ◽  
Cuiru Sun ◽  
Timothy W. H. Luk ◽  
Victor X. D. Yang ◽  
...  
Keyword(s):  
Wave Propagation ◽  
Shear Wave ◽  
Optical Coherence ◽  
Tissue Equivalent ◽  
Homogeneous Tissue

scholarly journals Development of optical coherence tomography technique for clinical diagnostics and monitoring

2021 ◽  
Author(s):  
Marjan Razani
Keyword(s):  
Optical Coherence Tomography ◽  
Carotid Artery ◽  
Shear Wave ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Optical Coherence ◽  
Swept Source ◽  
Tissue Equivalent ◽  
Oct Imaging

This dissertation describes techniques that use Optical Coherence Tomography techniques developed for the detection of shear wave propagation in different phantoms, and the use of such waves to enhance the transport of nanoparticles in tissue equivalent phantoms. In the first study, we explored the potential of measuring shear wave propagation using optical co-herence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a swept source optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, syn-chronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were com-posed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. In the second study, we present a technique to image the enhanced particle displacement generated using an acoustic radiation force (ARF) excitation source. A MEMS-VCSEL swept source Optical Coherence Tomography (SS-OCT) system with a center wavelength of 1310 nm, a bandwidth of 100nm, and an A-scan rate of 100 kHz was used to detect gold nanoparticle displacement. ARF was applied after the nanoparticles diffused into a collagen matrix (of different collagen concen-trations and for a tissue engineered MCF-7 breast cancer cell construct). Differential OCT speckle variance images with and without the ARF were used to estimate the particle dis-placement. The images were used to detect the microscopic enhancement of nanoparticle displacement generated by the ARF. Using this OCT imaging technique, the enhanced transport of particles though a collagen gel after using an ARF excitation was imaged and analysed.

scholarly journals Visualizing ultrasonically induced shear wave propagation using phase-sensitive optical coherence tomography for dynamic elastography

2014 ◽  
Vol 39 (4) ◽  
pp. 838 ◽  
Author(s):  
Thu-Mai Nguyen ◽  
Shaozhen Song ◽  
Bastien Arnal ◽  
Zhihong Huang ◽  
Matthew O’Donnell ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Wave Propagation ◽  
Shear Wave ◽  
Optical Coherence ◽  
Phase Sensitive

Visualization of ultrasonically induced shear wave propagation using phase sensitive optical coherence tomography

2014 ◽  
Author(s):  
Thu-Mai Nguyen ◽  
Shaozhen Song ◽  
Bastien Arnal ◽  
Emily Y. Wong ◽  
Ruikang K. Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Wave Propagation ◽  
Shear Wave ◽  
Optical Coherence ◽  
Phase Sensitive

scholarly journals Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

2014 ◽  
Vol 19 (1) ◽  
pp. 016013 ◽  
Author(s):  
Thu-Mai Nguyen ◽  
Shaozhen Song ◽  
Bastien Arnal ◽  
Emily Y. Wong ◽  
Zhihong Huang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Shear Wave ◽  
Pulse Compression ◽  
Optical Coherence ◽  
Wave Pulse ◽  
Phase Sensitive

Imaging pulse wave propagation in human retinal vessels using full-field swept-source optical coherence tomography

2015 ◽  
Vol 40 (20) ◽  
pp. 4771 ◽  
Author(s):  
Hendrik Spahr ◽  
Dierck Hillmann ◽  
Carola Hain ◽  
Clara Pfäffle ◽  
Helge Sudkamp ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Wave Propagation ◽  
Pulse Wave ◽  
Retinal Vessels ◽  
Optical Coherence ◽  
Pulse Wave Propagation ◽  
Swept Source ◽  
Full Field
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