Sentinel lymph nodes detection with an imaging system using Patent Blue V dye as fluorescent tracer

2013 ◽  
Author(s):  
F. Tellier ◽  
J. Steibel ◽  
R. Chabrier ◽  
J. F. Rodier ◽  
G. Pourroy ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Imaging System ◽  
Sentinel Lymph Nodes ◽  
Fluorescent Tracer ◽  
Patent Blue ◽  
Patent Blue V

scholarly journals Sentinel lymph nodes fluorescence detection and imaging using Patent Blue V bound to human serum albumin

2012 ◽  
Vol 3 (9) ◽  
pp. 2306 ◽  
Author(s):  
Franklin Tellier ◽  
Jérôme Steibel ◽  
Renée Chabrier ◽  
François Xavier Blé ◽  
Hervé Tubaldo ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Lymph Nodes ◽  
Human Serum ◽  
Fluorescence Detection ◽  
Sentinel Lymph Nodes ◽  
Patent Blue ◽  
Patent Blue V

scholarly journals Identification of sentinel lymph nodes in vulvar carcinoma patients with the aid of a patent blue V injection

Cancer ◽  
1999 ◽  
Vol 86 (4) ◽  
pp. 652-656 ◽  
Author(s):  
Anca C. Ansink ◽  
Daisy M. D. S. Sie-Go ◽  
Jacobus van der Velden ◽  
Edith A. Sijmons ◽  
Alberto de Barros Lopes ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Vulvar Carcinoma ◽  
Patent Blue ◽  
Patent Blue V

RT-PCR and immunohistochemical evaluation of sentinel lymph nodes afterin vivomapping with Patent Blue V in colon cancer patients

2006 ◽  
Vol 41 (9) ◽  
pp. 1073-1078 ◽  
Author(s):  
Wendy Kelder ◽  
Anke Van Den Berg ◽  
Judith Van Der Leij ◽  
Wim Bleeker ◽  
Anton T. M. G. Tiebosch ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Sentinel Lymph Nodes ◽  
Rt Pcr ◽  
Patent Blue ◽  
Patent Blue V

Sentinel Lymphadenectomy in Vulvar Cancer Using Near-Infrared Fluorescence From Indocyanine Green Compared With Technetium 99m Nanocolloid

2017 ◽  
Vol 27 (4) ◽  
pp. 805-812 ◽  
Author(s):  
Philipp Soergel ◽  
Hermann Hertel ◽  
Anna Kaarina Nacke ◽  
Rüdiger Klapdor ◽  
Thorsten Derlin ◽  
...  
Keyword(s):  
Lymph Node ◽  
Confidence Interval ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Near Infrared ◽  
Vulvar Cancer ◽  
Sentinel Lymph Nodes ◽  
Infrared Band ◽  
Green Is ◽  
Patent Blue

ObjectiveNowadays, sentinel diagnostic is performed using technetium 99m (99mTc) nanocolloid as a radioactive marker and sometimes patent blue. In the last years, indocyanine green has been evaluated for sentinel diagnostic in different tumor entities. Indocyanine green is a fluorescent molecule that emits a light signal in the near-infrared band after excitation. Our study aimed to evaluate indocyanine green compared with the criterion-standard99mTc-nanocolloid.MethodsWe included patients with primary, unifocal vulvar cancer of less than 4 cm with clinically node-negative groins in this prospective trial. Sentinel diagnostic was carried out using99mTc-nanocolloid, indocyanine green, and patent blue. We examined each groin for light signals from the near-infrared band, for radioactivity, and for blue staining. A sentinel lymph node was defined as a99mTc-nanocolloid–positive lymph node. All sentinel lymph nodes and all additional blue or fluorescent lymph nodes were excised and tested and then sent for histologic examination.ResultsIn all, 27 patients were included in whom we found 91 sentinel lymph nodes in 52 groins. All these lymph nodes were positive for indocyanine green, also giving a sensitivity of 100% (95% confidence interval [CI], 96.0%–100%) compared with99mTc-nanocolloid. Eight additional lymph nodes showed indocyanine green fluorescence but no99mTc positivity, so that the positive predictive value was 91.9% (95% confidence interval, 84.6%–96.5%). In 1 patient, a false-negative sentinel missed by all 3 modalities was found.ConclusionsOur results show that indocyanine green is a promising approach for inguinal sentinel identification in vulvar cancer with a similar sensitivity as radioactive99mTc-nanocolloid and worth to be evaluated in further studies.

scholarly journals In vivo photoacoustic and ultrasonic mapping of rat sentinel lymph nodes with a modified commercial ultrasound imaging system

2010 ◽  
Author(s):  
Todd N. Erpelding ◽  
Chulhong Kim ◽  
Manojit Pramanik ◽  
Zijian Guo ◽  
John Dean ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Ultrasound Imaging ◽  
Imaging System ◽  
Sentinel Lymph Nodes

scholarly journals INTRAOPERATIVE DETECTION OF SENTINEL LYMPH NODES USING INFRARED IMAGING SYSTEM IN LOCAL NON-SMALL CELL CARCINOMA OF LUNG

2015 ◽  
Vol 174 (4) ◽  
pp. 13-17 ◽  
Author(s):  
A. L. Akopov ◽  
G. V. Papayan ◽  
I. V. Chistyakov ◽  
A. .. Karlson ◽  
A. V. Gerasin ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Imaging System ◽  
Histological Study ◽  
Sentinel Lymph Nodes ◽  
Small Cell ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided

The article presents the results of the first domestic experience of intraoperative fluorescence mapping of sentinel lymph nodes in lung cancer. The research included 10 patients, who underwent surgery over the period of time from September 2013 to May 2014. After performing thoracotomy, the solution of indocyanine green (ICG) was injected using subpleural position above the tumor in 3-4 points. Fluorescence (ICG) image guided surgery was carried out by using infrared radiation (wave length 808 nm) on lung surface, root of lung, mediastinum in real time. Fluorescence lymph nodes were mapped. In case that metastatic lesions weren’t revealed in sentinel lymph nodes, they weren’t noted in other nodes. Method specificity consisted of 100%. Biopsy and histological study of sentinel lymph nodes mapped during fluorescence (ICG) image guided surgery could be useful for prevention of lymphodissection in patients with non-small cell carcinoma of lung.

scholarly journals Hemosiderin: a new marker for sentinel lymph node identification

2009 ◽  
Vol 24 (6) ◽  
pp. 432-436 ◽  
Author(s):  
Luiz Gonzaga Porto Pinheiro ◽  
Renato Santos de Oliveira Filho ◽  
Paulo Henrique Diógenes Vasques ◽  
Pedro Henrique de Oliveira Filgueira ◽  
Douglas Henning Pinheiro Aragão ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Breast Biopsy ◽  
Gamma Probe ◽  
Sentinel Lymph Nodes ◽  
Patent Blue ◽  
Sentinel Lymph Node Identification ◽  
Lymphatic Duct ◽  
The Right

PURPOSE: To evaluate and present our initial results of a new marker (hemosiderin) for mammary sentinel lymph node identification in an experimental model. METHODS: Skins mapped like a lymphatic duct draining to the axilla in patients submitted to breast biopsy, in our mastology service, stimulated us to try it in an animal model (female dogs). Our theory was that some blood derivate (hemosiderin) was captured by macrophages and accessed the lymphatic ducts in direction to the axilla. Six female dogs of no defined race were studied. We injected 0,2 ml of technetium on both superior mammary glands. After ten minutes, a 2,5 ml solution of hemolized blood (hemosiderin) from the own animal was injected in the subareolar lymphatic plexus on the left superior mammary gland and 2,5 ml of patent blue concomitantly and equally on the contralateral gland. Ten minutes after, incisions on both axilas were made to search, through the lymphatic mapping and a gamma probe, the sentinel lymph nodes. RESULTS: Seven brown sentinel lymph nodes were indentified and also radiomarked on the left axilla. Six blue sentinel lymph nodes were identified and also radiomarked on the right axilla. CONCLUSION: Preliminary studies of a potential new dye for sentinel lymph node identification are presented. It may be the change of the current use of the blue dyes and their severe side-effects on patients submitted to sentinel lymph node biopsies.

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