Radio-opaque isotropic fiber optic probes for in vivo photodynamic therapy dosimetry

1994 ◽  
Author(s):  
Emma J. Hudson ◽  
Mark R. Stringer ◽  
Hugo J. van Staveren ◽  
Michael A. Smith
Keyword(s):  
Photodynamic Therapy ◽  
Fiber Optic ◽  
Fiber Optic Probes

scholarly journals Optical pH Detection with U-Shaped Fiber-Optic Probes and Absorption Transducers

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Jakub Zajíc ◽  
Lenka Traplová ◽  
Vlastimil Matějec ◽  
Marie Pospíšilová ◽  
Ivo Bartoň
Keyword(s):  
Fiber Optic ◽  
Ph Monitoring ◽  
Porous Silica ◽  
Bromothymol Blue ◽  
Small Sample ◽  
Physiological Processes ◽  
Ph Indicators ◽  
Fiber Optic Probes ◽  
Ph Range

In medicine knowledge of pH values can provide us with information not only about the patients’ status but also about physiological processes in the patient’s body. Measurements of pH in small-sample volumes and online pH monitoring in vivo can be employed to obtain such information. For such measurements we have developed and investigated U-shaped fiber-optic probes with immobilized pH indicators in this paper. U-shaped probes with a diameter of about 2 mm were prepared. Three different pH indicators, methyl red, methyl orange, and bromothymol blue, were immobilized in two types of matrices, namely, porous silica (PS) and ethylcellulose (EC), and applied on the U-shaped probes. Changes in spectra of transmitted power were measured and calibration curves were determined from these spectra. It has been found that a working pH range of prepared probes was from 3.1 to 7.6. The maximum sensitivity was about 0.1 1/pH unit. Effects of structural relaxations of detection layers and indicator leaching observed in experiments are discussed.

scholarly journals CLINICAL PROBLEMS OF DIRECT DOSIMETRY (IN VIVO) IN CONTACT RADIATION THERAPY

2018 ◽  
Vol 7 (2) ◽  
pp. 19-24
Author(s):  
V. A. Titova ◽  
D. A. Kokontsev ◽  
T. S. Belle
Keyword(s):  
Radiation Therapy ◽  
Photodynamic Therapy ◽  
Fiber Optic ◽  
Absorbed Dose ◽  
Special Treatment ◽  
Effective Use ◽  
Contact Radiation ◽  
Clinical Problems ◽  
Treatment Surgery

The use of multicomponent methods of special treatment (surgery, polychemotherapy, radiation therapy, laser photodynamic therapy) in oncology requires the control of doses in the tumor and healthy organs with high accuracy. A method of direct dosimetry using fiber-optic scintillation dosimeter MCD-4 is proposed. The dosimeter is fixed on endostats and is visualized on CT/MRI. The coordinates are entered into the anatomical units and dosimetry calculations, the data are mapped, the doses are adjusted on medical grounds. The developed technique of direct dosimetry allows monitoring of the contact radiation therapy (CRT) procedure in real time and making the necessary changes and corrections during the treatment. The refinement of the absorbed dose values using calculations and direct dosimetry minimizes the risk of complications and ensures the possibility of effective use of other treatment methods, including photodynamic therapy, after CRT.

scholarly journals Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics

2020 ◽  
Vol 10 (24) ◽  
pp. 8836
Author(s):  
Pankaj Singh ◽  
Prabodh Pandey ◽  
Shivam Shukla ◽  
Naren Naik ◽  
Asima Pradhan
Keyword(s):  
Fiber Optic ◽  
Numerical Study ◽  
Fiber Optic Probe ◽  
Scattering Coefficients ◽  
Spatially Resolved ◽  
Fiber Optic Probes ◽  
Diagnosis Of Cancer ◽  
Optic Probe ◽  
In Vivo Diagnosis

Fiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries for epithelial cancer characterization based on spatially resolved reflectance data. As per the outcomes of this comparative study, a probe has been manufactured and using Monte Carlo look up table based inversion scheme, the absorption and scattering coefficients of the epithelium mimicking top layer have been recovered from noisy synthetic as well as experimental data.

Study of Fiber-Optic Probes for in vivo Medical Raman Spectroscopy

1999 ◽  
Vol 53 (6) ◽  
pp. 619-627 ◽  
Author(s):  
Martin G. Shim ◽  
Brian C. Wilson ◽  
Eric Marple ◽  
Michael Wach
Keyword(s):  
Raman Spectroscopy ◽  
Fiber Optic ◽  
Fiber Optic Probes

Fiber-Optic Probes for in Vivo Raman Spectroscopy in the High-Wavenumber Region

2005 ◽  
Vol 77 (20) ◽  
pp. 6747-6752 ◽  
Author(s):  
Luís F. Santos ◽  
Rolf Wolthuis ◽  
S. Koljenović ◽  
Rui M. Almeida ◽  
Gerwin J. Puppels
Keyword(s):  
Raman Spectroscopy ◽  
Fiber Optic ◽  
Fiber Optic Probes ◽  
In Vivo Raman Spectroscopy ◽  
Wavenumber Region

Dual-selective photodynamic therapy with a mitochondria-targeted photosensitizer and fiber optic cannula for malignant brain tumors

2019 ◽  
Vol 7 (7) ◽  
pp. 2812-2825 ◽  
Author(s):  
Ji Hee Kang ◽  
Young Tag Ko
Keyword(s):  
Photodynamic Therapy ◽  
Brain Tumors ◽  
Fiber Optic ◽  
Malignant Brain Tumors

In vivo application of dual-selective photodynamic therapy with a mitochondria-targeted photosensitizer and fiber optic cannula to orthotopic GBM-xenografted mice.

Evaluation of fiber optic probes for in-vivo Raman spectroscopy

1998 ◽  
Author(s):  
Martin G. Shim ◽  
Brian C. Wilson ◽  
Eric Marple ◽  
Michael L. Wach
Keyword(s):  
Raman Spectroscopy ◽  
Fiber Optic ◽  
Fiber Optic Probes ◽  
In Vivo Raman Spectroscopy

Fiber-optic probes for in vivo depth-resolved neuron-activity mapping

2010 ◽  
Vol 3 (10-11) ◽  
pp. 660-669 ◽  
Author(s):  
Lyubov V. Doronina-Amitonova ◽  
Il'ya V. Fedotov ◽  
Olga I. Ivashkina ◽  
Marina A. Zots ◽  
Andrei B. Fedotov ◽  
...  
Keyword(s):  
Fiber Optic ◽  
Neuron Activity ◽  
Fiber Optic Probes
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