scholarly journals Collagen fiber arrangement in normal and diseased cartilage studied by polarization sensitive nonlinear microscopy

2008 ◽  
Vol 13 (4) ◽  
pp. 044020 ◽  
Author(s):  
Jessica C. Mansfield ◽  
C. Peter Winlove ◽  
Julian Moger ◽  
Steve J. Matcher
1997 ◽  
Vol 18 (5) ◽  
pp. 297-299 ◽  
Author(s):  
Tomas Movin ◽  
Adel Gad ◽  
Peter Güntner ◽  
Zoltan Földhazy ◽  
Christer Rolf

Achilles tendon pain or rupture after fluoroquionolone treatment has been described as an uncommon adverse effect. We report two patients with ciprofloxacin-associated Achilles tendon disease, one with histopathological examination. Microscopic evaluation showed irregular collagen fiber arrangement, hypercellularity, and increased interfibrillar glycosaminoglycans. These pathological features are also seen in tendon overuse injuries in athletes.


1999 ◽  
Vol 61 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Hiroyoshi NINOMIYA ◽  
Tomo INOMATA ◽  
Kikumi OGIHARA

Author(s):  
Juliana Merheb Jordão ◽  
Mariana Fajgenbaum Feiges Stoliar ◽  
Sarah Sanches Melo ◽  
Giovana Liz Marioto de Campos ◽  
Lismary Aparecida de Forville Mesquita ◽  
...  

2021 ◽  
pp. 138527
Author(s):  
Nicholas R. Cross ◽  
Derek M. Hall ◽  
Serguei N. Lvov ◽  
Bruce E. Logan ◽  
Matthew J. Rau

Cartilage ◽  
2021 ◽  
pp. 194760352098877
Author(s):  
Roy D. Bloebaum ◽  
Andrew S. Wilson ◽  
William N. Martin

Objective There has been a debate as to the alignment of the collagen fibers. Using a hand lens, Sir William Hunter demonstrated that the collagen fibers ran perpendicular and later aspects were supported by Benninghoff. Despite these 2 historical studies, modern technology has conflicting data on the collagen alignment. Design Ten mature New Zealand rabbits were used to obtain 40 condyle specimens. The specimens were passed through ascending grades of alcohol, subjected to critical point drying (CPD), and viewed in the scanning electron microscope. Specimens revealed splits from the dehydration process. When observing the fibers exposed within the opening of the splits, parallel fibers were observed to run in a radial direction, normal to the surface of the articular cartilage, radiating from the deep zone and arcading as they approach the surface layer. After these observations, the same samples were mechanically fractured and damaged by scalpel. Results The splits in the articular surface created deep fissures, exposing parallel bundles of collagen fibers, radiating from the deep zone and arcading as they approach the surface layer. On higher magnification, individual fibers were observed to run parallel to one another, traversing radially toward the surface of the articular cartilage and arcading. Mechanical fracturing and scalpel damage induced on the same specimens with the splits showed randomly oriented fibers. Conclusion Collagen fiber orientation corroborates aspects of Hunter’s findings and compliments Benninghoff. Investigators must be aware of the limits of their processing and imaging techniques in order to interpret collagen fiber orientation in cartilage.


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