Reply to “Elastin fiber but not collagen fiber is decreased dramatically in the dermis of vitiligo patients”: possible mechanisms of decreased elastin fibers

2021 ◽  
Author(s):  
Joanna Khalil ◽  
Carla Stephan ◽  
Mazen Kurban ◽  
Ossama Abbas
Keyword(s):  
Collagen Fiber ◽  
Elastin Fiber

Low-fluence and low-density CO2 laser: histological analysis of collagen fiber changes in skin and its clinical repercussions in photorejuvenation

2021 ◽  
Author(s):  
Juliana Merheb Jordão ◽  
Mariana Fajgenbaum Feiges Stoliar ◽  
Sarah Sanches Melo ◽  
Giovana Liz Marioto de Campos ◽  
Lismary Aparecida de Forville Mesquita ◽  
...  
Keyword(s):  
Co2 Laser ◽  
Collagen Fiber ◽  
Histological Analysis ◽  
Low Density

A Review of the Collagen Orientation in the Articular Cartilage

Cartilage ◽  
2021 ◽  
pp. 194760352098877
Author(s):  
Roy D. Bloebaum ◽  
Andrew S. Wilson ◽  
William N. Martin
Keyword(s):  
Surface Layer ◽  
Articular Cartilage ◽  
Fiber Orientation ◽  
Collagen Fiber ◽  
Articular Surface ◽  
Imaging Techniques ◽  
Collagen Fibers ◽  
Deep Zone ◽  
Collagen Fiber Orientation ◽  
Critical Point Drying

Objective There has been a debate as to the alignment of the collagen fibers. Using a hand lens, Sir William Hunter demonstrated that the collagen fibers ran perpendicular and later aspects were supported by Benninghoff. Despite these 2 historical studies, modern technology has conflicting data on the collagen alignment. Design Ten mature New Zealand rabbits were used to obtain 40 condyle specimens. The specimens were passed through ascending grades of alcohol, subjected to critical point drying (CPD), and viewed in the scanning electron microscope. Specimens revealed splits from the dehydration process. When observing the fibers exposed within the opening of the splits, parallel fibers were observed to run in a radial direction, normal to the surface of the articular cartilage, radiating from the deep zone and arcading as they approach the surface layer. After these observations, the same samples were mechanically fractured and damaged by scalpel. Results The splits in the articular surface created deep fissures, exposing parallel bundles of collagen fibers, radiating from the deep zone and arcading as they approach the surface layer. On higher magnification, individual fibers were observed to run parallel to one another, traversing radially toward the surface of the articular cartilage and arcading. Mechanical fracturing and scalpel damage induced on the same specimens with the splits showed randomly oriented fibers. Conclusion Collagen fiber orientation corroborates aspects of Hunter’s findings and compliments Benninghoff. Investigators must be aware of the limits of their processing and imaging techniques in order to interpret collagen fiber orientation in cartilage.

Collagen Fiber Morphology Determines Echogenicity of Myocardial Scar: Implications for Image Interpretation

2006 ◽  
Vol 23 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Ghasan M. Tabel ◽  
Peter Whittaker ◽  
Konstantinos Vlachonassios ◽  
Mehul Sonawala ◽  
P. Anthony Chandraratna
Keyword(s):  
Collagen Fiber ◽  
Image Interpretation ◽  
Myocardial Scar ◽  
Fiber Morphology

scholarly journals Enhanced osteoprogenitor elongated collagen fiber matrix formation by bioactive glass ionic silicon dependent on Sp7 (osterix) transcription

2016 ◽  
Vol 104 (10) ◽  
pp. 2604-2615 ◽  
Author(s):  
Venu G. Varanasi ◽  
Tetsurou Odatsu ◽  
Timothy Bishop ◽  
Joyce Chang ◽  
Jeremy Owyoung ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Collagen Fiber ◽  
Fiber Matrix

scholarly journals Evaluation of Collagen Alterations in Early Precursor Lesions of High Grade Serous Ovarian Cancer by Second Harmonic Generation Microscopy and Mass Spectrometry

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2794
Author(s):  
Kristal L. Gant ◽  
Alexander N. Jambor ◽  
Zihui Li ◽  
Eric C. Rentchler ◽  
Paul Weisman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ovarian Cancer ◽  
Second Harmonic Generation ◽  
Harmonic Generation ◽  
Collagen Fiber ◽  
Second Harmonic ◽  
Mass Spectrometry Analysis ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Fiber Morphology

Background: The collagen architecture in high grade serous ovarian cancer (HGSOC) is highly remodeled compared to the normal ovary and the fallopian tubes (FT). We previously used Second Harmonic Generation (SHG) microscopy and machine learning to classify the changes in collagen fiber morphology occurring in serous tubal intraepithelial carcinoma (STIC) lesions that are concurrent with HGSOC. We now extend these studies to examine collagen remodeling in pure p53 signatures, STICs and normal regions in tissues that have no concurrent HGSOC. This is an important distinction as high-grade disease can result in distant collagen changes through a field effect mechanism. Methods: We trained a linear discriminant model based on SHG texture and image features as a classifier to discriminate the tissue groups. We additionally performed mass spectrometry analysis of normal and HGSOC tissues to associate the differential expression of collagen isoforms with collagen fiber morphology alterations. Results: We quantified the differences in the collagen architecture between normal tissue and the precursors with good classification accuracy. Through proteomic analysis, we identified the downregulation of single α-chains including those for Col I and III, where these results are consistent with our previous SHG-based supramolecular analyses. Conclusion: This work provides new insights into ECM remodeling in early ovarian cancer and suggests the combined use of SHG microscopy and mass spectrometry as a new diagnostic/prognostic approach.

scholarly journals Effects of collagen fiber addition on the combustion and thermal stability of natural rubber

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Weixing Xu ◽  
Xintao Wu ◽  
Qilin Wen ◽  
Shuangyang Li ◽  
Yongjiao Song ◽  
...  
Keyword(s):  
Natural Rubber ◽  
Flame Retardant ◽  
Nitrogen Content ◽  
Flame Retardancy ◽  
Collagen Fiber ◽  
Oxygen Index ◽  
Air Pockets ◽  
Thermal Stability Of ◽  
Limited Oxygen ◽  
Properties Of Composites

Abstract Collagen fiber (CF) and silane coupling agent-modified collagen fiber (MCF) were used as flame retardant filler for natural rubber (NR) modification. The combustion phenomena and properties of composites blended with different dosages of CF or MCF were compared to elucidate the flame retardant mechanism of the composites. The flame retardancy of NR can be enhanced effectively by increasing nitrogen content (the nitrogen content of CF is about 18%), creating air pockets, and structuring the flame retardant network in the composites. MCF failed to structure a flame retardant network in the composite, indicating that its modification effects of MCF are weaker than those of CF. When CF dosage was 30 wt%, the composite can achieve the best flame retardancy, with limited oxygen index of 29.4% and without smoke and dripping during burning. This study demonstrated a new method for the flame retardant modification of NR. Graphical abstract

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