Measurements of the binding force between the Helicobacter pylori adhesin BabA and the Lewis b blood group antigen using optical tweezers

2005 ◽  
Vol 10 (4) ◽  
pp. 044024 ◽  
Author(s):  
Oscar Björnham ◽  
Erik Fällman ◽  
Ove Axner ◽  
Jörgen Ohlsson ◽  
Ulf J. Nilsson ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Optical Tweezers ◽  
Blood Group Antigen ◽  
Binding Force ◽  
B Blood Group

Blood group antigen-Binding Adhesion2 (BabA2) gene in gastric tissue biopsies as a diagnostic biomarker for Helicobacter pylori infection

2019 ◽  
Vol 27 (3) ◽  
pp. 193-199 ◽  
Author(s):  
Ashraf A. Hassan ◽  
Amany I. Youssef ◽  
Abeer A. Ghazal ◽  
Manal I. Sheta ◽  
Nabil L. Diwedar ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Helicobacter Pylori Infection ◽  
Antigen Binding ◽  
Gastric Tissue ◽  
Diagnostic Biomarker

Role of Lewis A and Lewis B Blood Group Antigens in Helicobacter pylori Infection

Helicobacter ◽  
2004 ◽  
Vol 9 (4) ◽  
pp. 324-329 ◽  
Author(s):  
Dietrich Rothenbacher ◽  
Maria Weyermann ◽  
Gunter Bode ◽  
Murrat Kulaksiz ◽  
Bernd Stahl ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Helicobacter Pylori Infection ◽  
Blood Group Antigens ◽  
B Blood Group ◽  
Lewis A

scholarly journals Multiple Chromosomal Loci for the babA Gene in Helicobacter pylori

2006 ◽  
Vol 74 (5) ◽  
pp. 3046-3051 ◽  
Author(s):  
Ewa E. Hennig ◽  
Johnna M. Allen ◽  
Timothy L. Cover
Keyword(s):  
Phylogenetic Analysis ◽  
Helicobacter Pylori ◽  
Membrane Protein ◽  
Protein Expression ◽  
Outer Membrane Protein ◽  
Blood Group Antigen ◽  
Chromosomal Locus ◽  
H Pylori ◽  
Chromosomal Loci ◽  
B Blood Group

ABSTRACT Helicobacter pylori babA encodes an outer membrane protein that binds to fucosylated Lewis b blood group antigen. We analyzed a panel of 35 H. pylori strains and identified three possible chromosomal loci for babA. There was a significant association between the presence of babA and the presence of cagA (P = 0.0001). Phylogenetic analysis of babA alleles revealed two divergent families of signal sequences. Among 17 strains in which an intact in-frame babA allele was identified, 10 expressed a detectable BabA protein. Expression of a BabA protein and the Lewis b-binding phenotype were not dependent on the chromosomal locus of babA. These data indicate that there is marked heterogeneity among H. pylori strains in babA genetic content and BabA expression.

scholarly journals Helicobacter Pylori: How is Adhesin BabA, a Blood Group Antigen Binding Membrane Protein, Involved in Bacterial Adherence?

2009 ◽  
Vol 96 (3) ◽  
pp. 409a ◽  
Author(s):  
Katja Petzold ◽  
Annelie Olofsson ◽  
Anna Arnqvist ◽  
Thomas Boren ◽  
Gerhard Gröbner ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Membrane Protein ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Bacterial Adherence ◽  
Antigen Binding

scholarly journals Atomic force microscopy measurements reveal multiple bonds between Helicobacter pylori blood group antigen binding adhesin and Lewis b ligand

2014 ◽  
Vol 11 (101) ◽  
pp. 20141040 ◽  
Author(s):  
P. Parreira ◽  
Q. Shi ◽  
A. Magalhaes ◽  
C. A. Reis ◽  
J. Bugaytsova ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Helicobacter Pylori ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Antigen Binding ◽  
Dynamic Force ◽  
Force Microscopy ◽  
Single Receptor ◽  
Atomic Force ◽  
Assembled Monolayers

The strength of binding between the Helicobacter pylori blood group antigen-binding adhesin (BabA) and its cognate glycan receptor, the Lewis b blood group antigen (Le b ), was measured by means of atomic force microscopy. High-resolution measurements of rupture forces between single receptor–ligand pairs were performed between the purified BabA and immobilized Le b structures on self-assembled monolayers. Dynamic force spectroscopy revealed two similar but statistically different bond populations. These findings suggest that the BabA may form different adhesive attachments to the gastric mucosa in ways that enhance the efficiency and stability of bacterial adhesion.

scholarly journals Effects of Blood Group Antigen–Binding Adhesin Expression during Helicobacter pylori Infection of Mongolian Gerbils

2011 ◽  
Vol 203 (5) ◽  
pp. 726-735 ◽  
Author(s):  
Tomoyuki Ohno ◽  
Anna Vallström ◽  
Massimo Rugge ◽  
Hiroyoshi Ota ◽  
David Y. Graham ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Helicobacter Pylori Infection ◽  
Antigen Binding ◽  
Mongolian Gerbils

Expression of Lewis (b) blood group antigen interferes with oral dienogest therapy among women with adenomyosis

2020 ◽  
Vol 137 ◽  
pp. 103079
Author(s):  
Jing Xue ◽  
Lei Li ◽  
Feifei Li ◽  
Na Li ◽  
Tao Li ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Group Antigen ◽  
B Blood Group
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