Blood group antigen-Binding Adhesion2 (BabA2) gene in gastric tissue biopsies as a diagnostic biomarker for Helicobacter pylori infection

2019 ◽  
Vol 27 (3) ◽  
pp. 193-199 ◽  
Author(s):  
Ashraf A. Hassan ◽  
Amany I. Youssef ◽  
Abeer A. Ghazal ◽  
Manal I. Sheta ◽  
Nabil L. Diwedar ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Helicobacter Pylori Infection ◽  
Antigen Binding ◽  
Gastric Tissue ◽  
Diagnostic Biomarker

scholarly journals Effects of Blood Group Antigen–Binding Adhesin Expression during Helicobacter pylori Infection of Mongolian Gerbils

2011 ◽  
Vol 203 (5) ◽  
pp. 726-735 ◽  
Author(s):  
Tomoyuki Ohno ◽  
Anna Vallström ◽  
Massimo Rugge ◽  
Hiroyoshi Ota ◽  
David Y. Graham ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Helicobacter Pylori Infection ◽  
Antigen Binding ◽  
Mongolian Gerbils

scholarly journals Helicobacter Pylori: How is Adhesin BabA, a Blood Group Antigen Binding Membrane Protein, Involved in Bacterial Adherence?

2009 ◽  
Vol 96 (3) ◽  
pp. 409a ◽  
Author(s):  
Katja Petzold ◽  
Annelie Olofsson ◽  
Anna Arnqvist ◽  
Thomas Boren ◽  
Gerhard Gröbner ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Membrane Protein ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Bacterial Adherence ◽  
Antigen Binding

scholarly journals Atomic force microscopy measurements reveal multiple bonds between Helicobacter pylori blood group antigen binding adhesin and Lewis b ligand

2014 ◽  
Vol 11 (101) ◽  
pp. 20141040 ◽  
Author(s):  
P. Parreira ◽  
Q. Shi ◽  
A. Magalhaes ◽  
C. A. Reis ◽  
J. Bugaytsova ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Helicobacter Pylori ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Antigen Binding ◽  
Dynamic Force ◽  
Force Microscopy ◽  
Single Receptor ◽  
Atomic Force ◽  
Assembled Monolayers

The strength of binding between the Helicobacter pylori blood group antigen-binding adhesin (BabA) and its cognate glycan receptor, the Lewis b blood group antigen (Le b ), was measured by means of atomic force microscopy. High-resolution measurements of rupture forces between single receptor–ligand pairs were performed between the purified BabA and immobilized Le b structures on self-assembled monolayers. Dynamic force spectroscopy revealed two similar but statistically different bond populations. These findings suggest that the BabA may form different adhesive attachments to the gastric mucosa in ways that enhance the efficiency and stability of bacterial adhesion.

Helicobacter pylori blood group antigen-binding adhesin, baba, and clinical outcome: Studies in four countries

2000 ◽  
Vol 118 (4) ◽  
pp. A1327
Author(s):  
Yoshio Yamaoka ◽  
Anna Arnqvist ◽  
Thomas Boren ◽  
Rainer Haas ◽  
Michael S. Osato ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Outcome ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Outcome Studies ◽  
Antigen Binding

scholarly journals Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin

1999 ◽  
Vol 96 (22) ◽  
pp. 12778-12783 ◽  
Author(s):  
M. Gerhard ◽  
N. Lehn ◽  
N. Neumayer ◽  
T. Boren ◽  
R. Rad ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Clinical Relevance ◽  
Blood Group Antigen ◽  
Antigen Binding

scholarly journals Frequency of Helicobacter pylori blood-group antigen-binding adhesion 2 and sialic acid binding adhesion genes among dyspeptic patients in Tabriz, Iran

2015 ◽  
Vol 3 (2) ◽  
pp. 71-76 ◽  
Author(s):  
Leila Yousefi ◽  
Reza Ghotaslou ◽  
Mohammad Taghi Akhi ◽  
Mohammad Asgharzadeh ◽  
Mohammad Reza Nahaei ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Sialic Acid ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Antigen Binding ◽  
Sialic Acid Binding

Plasma and Gastric Tissue Selenium Levels in Patients with Helicobacter pylori Infection

2001 ◽  
Vol 32 (5) ◽  
pp. 405-408 ◽  
Author(s):  
Yücel Üstündağ ◽  
Sedat Boyacioğlu ◽  
Ayşegül Haberal ◽  
Beyhan Demirhan ◽  
Banu Bilezikçi
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Gastric Tissue ◽  
Tissue Selenium

Lactobacillus fermentum UCO-979C beneficially modulates the innate immune response triggered by Helicobacter pylori infection in vitro

2018 ◽  
Vol 9 (5) ◽  
pp. 829-841 ◽  
Author(s):  
V. Garcia-Castillo ◽  
H. Zelaya ◽  
A. Ilabaca ◽  
M. Espinoza-Monje ◽  
R. Komatsu ◽  
...  
Keyword(s):  
Immune Response ◽  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Morphological Changes ◽  
Helicobacter Pylori Infection ◽  
Lactobacillus Fermentum ◽  
Gastric Tissue ◽  
Gastric Epithelial Cells ◽  
Ags Cells ◽  
H Pylori

Helicobacter pylori infection is associated with important gastric pathologies. An aggressive proinflammatory immune response is generated in the gastric tissue infected with H. pylori, resulting in gastritis and a series of morphological changes that increase the susceptibility to cancer development. Probiotics could present an alternative solution to prevent or decrease H. pylori infection. Among them, the use of immunomodulatory lactic acid bacteria represents a promising option to reduce the severity of chronic inflammatory-mediated tissue damage and to improve protective immunity against H. pylori. We previously isolated Lactobacillus fermentum UCO-979C from human gastric tissue and demonstrated its capacity to reduce adhesion of H. pylori to human gastric epithelial cells (AGS cells). In this work, the ability of L. fermentum UCO-979C to modulate immune response in AGS cells and PMA phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 (human monocytic leukaemia) macrophages in response to H. pylori infection was evaluated. We demonstrated that the UCO-979C strain is able to differentially modulate the cytokine response of gastric epithelial cells and macrophages after H. pylori infection. Of note, L. fermentum UCO-979C was able to significantly reduce the production of inflammatory cytokines and chemokines in AGS and THP-1 cells as well as increase the levels of immunoregulatory cytokines, indicating a remarkable anti-inflammatory effect. These findings strongly support the probiotic potential of L. fermentum UCO-979C and provide evidence of its beneficial effects against the inflammatory damage induced by H. pylori infection. Although our findings should be proven in appropriate experiments in vivo, in both H. pylori infection animal models and human trials, the results of the present work provide a scientific rationale for the use of L. fermentum UCO-979C to prevent or reduce H. pylori-induced gastric inflammation in humans.

Role of Lewis A and Lewis B Blood Group Antigens in Helicobacter pylori Infection

Helicobacter ◽  
2004 ◽  
Vol 9 (4) ◽  
pp. 324-329 ◽  
Author(s):  
Dietrich Rothenbacher ◽  
Maria Weyermann ◽  
Gunter Bode ◽  
Murrat Kulaksiz ◽  
Bernd Stahl ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Helicobacter Pylori Infection ◽  
Blood Group Antigens ◽  
B Blood Group ◽  
Lewis A
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