Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer

2005 ◽  
Vol 10 (2) ◽  
pp. 024032 ◽  
Author(s):  
Changfang Zhu ◽  
Gregory M. Palmer ◽  
Tara M. Breslin ◽  
Fushen Xu ◽  
Nirmala Ramanujam
Keyword(s):  
Breast Cancer ◽  
Fiber Optic ◽  
Fiber Optic Probe ◽  
Optical Diagnosis ◽  
Optic Probe

scholarly journals Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model

2017 ◽  
Vol 2017 ◽  
pp. 1-9
Author(s):  
Myeongsu Seong ◽  
NoSoung Myoung ◽  
Songhyun Lee ◽  
Hyeryun Jeong ◽  
Sang-Youp Yim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Animal Model ◽  
Raman Spectra ◽  
Fiber Optic ◽  
Animal Experiments ◽  
Small Animal ◽  
Fiber Optic Probe ◽  
Small Animal Model ◽  
Biochemical Compositions ◽  
Optic Probe

The cancer field effect (CFE) has been highlighted as one of indirect indications for tissue variations that are insensitive to conventional diagnostic techniques. In this research, we had a hypothesis that chemotherapy for breast cancer would affect skin biochemical compositions that would be reflected by Raman spectral changes. We used a fiber-optic probe-based Raman spectroscopy to perform preliminary animal experiments to validate the hypothesis. Firstly, we verified the probing depth of the fiber-optic probe (~800 μm) using a simple intravenous fat emulsion-filled phantom having a silicon wafer at the bottom inside a cuvette. Then, we obtained Raman spectra during breast cancer treatment by chemotherapy from a small animal model in longitudinal manner. Our results showed that the treatment causes variations of biochemical compositions in the skin. For further validation, the Raman spectra will have to be collected from more populations and spectra will need to be compared with immunohistochemistry of the breast tissue.

Synthesis, performance and growth mechanism of silver nanoparticle coated SERS fiber probe

2019 ◽  
Vol 107 (3) ◽  
pp. 305
Author(s):  
Mengmei Geng ◽  
Yuting Long ◽  
Tongqing Liu ◽  
Zijuan Du ◽  
Hong Li ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Absorption Spectrum ◽  
Reaction Time ◽  
Growth Mechanism ◽  
Fiber Optic ◽  
Fiber Optic Probe ◽  
Visible Absorption ◽  
Fiber Probe ◽  
Surface Enhanced Raman ◽  
Optic Probe

Surface-enhanced Raman Scattering (SERS) fiber probe provides abundant interaction area between light and materials, permits detection within limited space and is especially useful for remote or in situ detection. A silver decorated SERS fiber optic probe was prepared by hydrothermal method. This method manages to accomplish the growth of silver nanoparticles and its adherence on fiber optic tip within one step, simplifying the synthetic procedure. The effects of reaction time on phase composition, surface plasmon resonance property and morphology were investigated by X-ray diffraction analysis (XRD), ultraviolet-visible absorption spectrum (UV-VIS absorption spectrum) and scanning electron microscope (SEM). The results showed that when reaction time is prolonged from 4–8 hours at 180 °C, crystals size and size distribution of silver nanoparticles increase. Furthermore, the morphology, crystal size and distribution density of silver nanoparticles evolve along with reaction time. A growth mechanism based on two factors, equilibrium between nucleation and growth, and the existence of PVP, is hypothesized. The SERS fiber probe can detect rhodamin 6G (R6G) at the concentration of 10−6 M. This SERS fiber probe exhibits promising potential in organic dye and pesticide residue detection.

Evaluation of Dry-Wet Transition in PEFC Under Load Changes Based on Laser Spectroscopy Using Fiber-Optic Probe

2019 ◽  
Vol 92 (8) ◽  
pp. 119-124
Author(s):  
Kosuke Nishida ◽  
Ryoga Nakauchi ◽  
Yuma Tabata ◽  
Toyofumi Umekawa ◽  
Masahiro Kawasaki
Keyword(s):  
Laser Spectroscopy ◽  
Fiber Optic ◽  
Fiber Optic Probe ◽  
Optic Probe

scholarly journals Autofluorescence and diffuse reflectance spectroscopy of oral epithelial tissue using a depth-sensitive fiber-optic probe

2008 ◽  
Vol 47 (6) ◽  
pp. 825 ◽  
Author(s):  
Richard A. Schwarz ◽  
Wen Gao ◽  
Dania Daye ◽  
Michelle D. Williams ◽  
Rebecca Richards-Kortum ◽  
...  
Keyword(s):  
Diffuse Reflectance ◽  
Fiber Optic ◽  
Diffuse Reflectance Spectroscopy ◽  
Reflectance Spectroscopy ◽  
Epithelial Tissue ◽  
Fiber Optic Probe ◽  
Optic Probe ◽  
Oral Epithelial
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