Imaging deoxyribose nucleic acid molecules on a metal surface under water by scanning tunneling microscopy

1988 ◽  
Vol 6 (2) ◽  
pp. 544-547 ◽  
Author(s):  
S. M. Lindsay ◽  
B. Barris
Keyword(s):  
Nucleic Acid ◽  
Scanning Tunneling Microscopy ◽  
Metal Surface ◽  
Scanning Tunneling ◽  
Tunneling Microscopy ◽  
Deoxyribose Nucleic Acid

Imaging of Nucleic Acid Base Molecules on Pd(110) Surfaces by Scanning Tunneling Microscopy

1996 ◽  
Vol 35 (Part 2, No. 2B) ◽  
pp. L244-L246 ◽  
Author(s):  
Hiroyuki Tanaka ◽  
Jun Yoshinobu ◽  
Maki Kawai ◽  
Tomoji Kawai
Keyword(s):  
Nucleic Acid ◽  
Scanning Tunneling Microscopy ◽  
Scanning Tunneling ◽  
Tunneling Microscopy ◽  
Acid Base ◽  
Nucleic Acid Base

Direct imaging of nucleic acid conformation in water by scanning tunneling microscopy

1989 ◽  
Vol 47 ◽  
pp. 36-37
Author(s):  
S.M. Lindsay ◽  
L. Nagahara ◽  
T. Thundat
Keyword(s):  
Nucleic Acid ◽  
Scanning Tunneling Microscopy ◽  
Random Sequence ◽  
Biological Molecules ◽  
Scanning Tunneling ◽  
Biological Processes ◽  
Tunneling Microscopy ◽  
Atomic Force ◽  
High Resolution Images ◽  
Nucleic Acid Conformation

We have developed methods for imaging biopolymers under water by scanning tunneling microscopy (STM). The STM gives fairly high resolution images of small biopolymers. Larger polymers may be imaged with the atomic force microscope. Both techniques allow biological processes to be studied as they occur. Both suffer limits on resolution which are a consequence of the distortion of soft biological molecules by the contact force of the probe. The chemical sensitivity of the STM can be exploited to overcome this limitation, and we will discuss methods for nucleic acid sequencing.A number of images of nucleic acids in various configurations are displayed on the following page. All are perspective projections looking into the substrate at an angle of about 45° with respect to the axes. (A) shows a random-sequence fragment of double helical DNA. The 36Å helix repeat is clearly visible. (B) shows a single strand of poly (rU). (C) Shows (left side) three complete 146 base-pair fragments of DNA from the nucleosome. (D) shows a kinked nucleosome fragment.

scholarly journals Enhancing intramolecular features and identifying defects in organic and hybrid nanoarchitectures on a metal surface at room temperature using a NaCl-functionalized scanning tunneling microscopy tip

RSC Advances ◽  
2017 ◽  
Vol 7 (81) ◽  
pp. 51055-51061 ◽  
Author(s):  
David Peyrot ◽  
Fabien Silly
Keyword(s):  
Scanning Tunneling Microscopy ◽  
Electronic Properties ◽  
Metal Surface ◽  
Room Temperature ◽  
Scanning Tunneling ◽  
Two Dimensional ◽  
Powerful Method ◽  
Tunneling Microscopy

Scanning tunneling microscopy using an NaCl-functionalised tip is a powerful method to assess the morphology of two-dimensional nanoarchitectures and their local variations of electronic properties.

A study on α-RuCl3 crystal structure by scanning tunneling microscopy

1989 ◽  
Vol 47 ◽  
pp. 30-31
Author(s):  
H.-J. Cantow ◽  
H. Hillebrecht ◽  
S. Magonov ◽  
H. W. Rotter ◽  
G. Thiele
Keyword(s):  
Crystal Structure ◽  
Density Distribution ◽  
Scanning Tunneling Microscopy ◽  
Electron Density ◽  
Structure Determination ◽  
Electron Density Distribution ◽  
Scanning Tunneling ◽  
Monoclinic Space Group ◽  
Tunneling Microscopy ◽  
X Ray

From X-ray analysis, the conclusions are drawn from averaged molecular informations. Thus, limitations are caused when analyzing systems whose symmetry is reduced due to interatomic interactions. In contrast, scanning tunneling microscopy (STM) directly images atomic scale surface electron density distribution, with a resolution up to fractions of Angstrom units. The crucial point is the correlation between the electron density distribution and the localization of individual atoms, which is reasonable in many cases. Thus, the use of STM images for crystal structure determination may be permitted. We tried to apply RuCl3 - a layered material with semiconductive properties - for such STM studies. From the X-ray analysis it has been assumed that α-form of this compound crystallizes in the monoclinic space group C2/m (AICI3 type). The chlorine atoms form an almost undistorted cubic closed package while Ru occupies 2/3 of the octahedral holes in every second layer building up a plane hexagon net (graphite net). Idealizing the arrangement of the chlorines a hexagonal symmetry would be expected. X-ray structure determination of isotypic compounds e.g. IrBr3 leads only to averaged positions of the metal atoms as there exist extended stacking faults of the metal layers.

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