Incorporation of nanostructured hydroxyapatite and poly(N-isopropylacrylamide) in demineralized bone matrix enhances osteoblast and human mesenchymal stem cell activity

2015 ◽  
Vol 10 (4) ◽  
pp. 041001 ◽  
Author(s):  
Alessandro Nicoletti ◽  
Paola Torricelli ◽  
Adriana Bigi ◽  
Piermaria Fornasari ◽  
Milena Fini ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Cell Activity ◽  
Human Mesenchymal Stem Cell ◽  
Stem Cell Activity ◽  
Demineralized Bone

scholarly journals In Vitro Comparative Study of Osteogenic Differentiation Ability between Adipose and Bone Marrow Mesenchymal Stem Cell Applied to Bovine Demineralized Bone Matrix

2018 ◽  
Vol 38 ◽  
pp. 59-66 ◽  
Author(s):  
Ferdiansyah Mahyudin ◽  
Dwikora Novembri Utomo ◽  
Mouli Edward ◽  
Lukas Widhiyanto ◽  
Christopher Anthony Simanjuntak ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Zealand White Rabbit ◽  
Tissue Engineering Application ◽  
Alkaline Phosphate ◽  
Demineralized Bone

Ideal bone graft must possess the desirable trait such as osteoconductive, osteoinductive and osteogenesis. Demineralized Bone Matrix (DBM) provides both osteoconductive and osteoinductive trait. Referring to the tissue engineering principle, the addition of mesenchymal stem cell would add the osteogenic trait to this procedure. The design of this study is experimental using Bovine DBM. Bone Marrow Mesenchymal Stem Cell (BMSCs) and Adipose Mesenchymal Stem Cells (ASCs) were taken from New Zealand white rabbit. There are two groups of treatment, divided into DBM implanted with BMSCs and DBM implanted with ASCs. Each BMSCs and ASCs groups is incubated in the normal and osteogenic culture plate. Evaluation is performed by counting the osteoblast and immunohistochemistry stain using Alkaline Phosphate and Osteocalcin. After 4 weeks of incubation, we found that the osteoblast count in BMSCs groups is higher compared to the ASCs groups in both culture condition (p<0.01) along with Alkaline Phosphate staining (p<0.05), while the Osteocalcin staining showed insignificant differences (p>0.05). This study revealed that xenogenic bovine DBM can act as the potential osteoinductive scaffold for the MSCs to differentiate. The tissue engineering application by combining MSCs and Bovine DBM can be considered as an alternative in managing bone defect cases.

scholarly journals Hair-follicle mesenchymal stem-cell activity during homeostasis and wound healing

2021 ◽  
Author(s):  
Emil Aamar ◽  
Efrat Avigad Laron ◽  
Wisal Asaad ◽  
Sarina Harshuk-Shabso ◽  
David Enshell-Seijffers
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Hair Follicle ◽  
Cell Activity ◽  
Stem Cell Activity

scholarly journals Incorporating β-cyclodextrin into collagen scaffolds to sequester growth factors and modulate mesenchymal stem cell activity

2018 ◽  
Vol 76 ◽  
pp. 116-125 ◽  
Author(s):  
William K. Grier ◽  
Aleczandria S. Tiffany ◽  
Matthew D. Ramsey ◽  
Brendan A.C. Harley
Keyword(s):  
Stem Cell ◽  
Growth Factors ◽  
Mesenchymal Stem Cell ◽  
Cell Activity ◽  
Collagen Scaffolds ◽  
Stem Cell Activity

Regulation of Mesenchymal Stem Cell Activity by Endothelial Cells

2011 ◽  
Vol 20 (3) ◽  
pp. 391-403 ◽  
Author(s):  
Fatima A. Saleh ◽  
Muna Whyte ◽  
Peter Ashton ◽  
Paul G. Genever
Keyword(s):  
Endothelial Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Activity ◽  
Stem Cell Activity

scholarly journals Effects of Poor Maternal Nutrition during Gestation on Bone Development and Mesenchymal Stem Cell Activity in Offspring

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168382 ◽  
Author(s):  
Sambhu M. Pillai ◽  
Nicole H. Sereda ◽  
Maria L. Hoffman ◽  
Ellen V. Valley ◽  
Thomas D. Crenshaw ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Maternal Nutrition ◽  
Bone Development ◽  
Cell Activity ◽  
Stem Cell Activity
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