Science and engineering of nanodiamond particle surfaces for biological applications (Review)

The official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada / Société de, Microscopie du Canada, Mexican Microscopy Society, Brazilian Society for Microscopy and Microanalysis, Venezuelan Society of Electron Microscopy, European Microbeam Analysis Society, Australian Microscopy and Microanalysis Society.Published in affiliation with Royal Microscopical Society, German Society for Electron Microscopy, Belgian Society for Microscopy, Microscopy Society of Southern Africa.Editor in Chief, Editor, Microanalysis: Charles E. Lyman, Materials Science and Engineering, Lehigh University, 5 East Packer Avenue, Bethlehem, Pennsylvania 18015-3195, Phone: (610) 758-4249, Fax: (610) 758-4244, e-mail: [email protected], Biological Applications: Ralph Albrecht, Department of Animal Sciences, University of Wisconsin-Madison, 1675 Observatory Drive, Madison, Wisconsin 53706-1581, Phone: (608) 263-3952, Fax: (608) 262-5157, e-mail: [email protected], Materials Applications: David J. Smith, Center for Solid State Science, Arizona State University, Tempe, Arizona 85287-1704, Phone: (480) 965-4540, Fax: (480) 965-9004, e-mail: [email protected], Materials Applications: Elizabeth Dickey, Materials Science and Engineering, Pennsylvania State University, 223 MRL Building, University Park, PA 16802-7003, Phone: (814) 865-9067, Fax: (814) 863-8561, e-mail: [email protected], Light and Scanning Probe, Microscopies: Brian Herman, Cellular and Structural Biology, University of Texas at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7762, Phone: (210) 567-3800, Fax: (210) 567-3803, e-mail: [email protected], Biological Applications: Heide Schatten, Veterinary Pathobiology, University of Missouri-Columbia, 1600 E. Rollins Street, Columbia, Missouri 65211-5030, Phone: (573) 882-2396, Fax: (573) 884-5414, e-mail: [email protected] Editor, Book Review Editor: JoAn Hudson, Advanced Materials Research Labs., Clemson Univ. Research Park, Rm. 105, Anderson, SC 29625, Phone: (864) 656-7535, Fax: (864) 656-2466, e-mail: [email protected] Section Editor: James N. Turner, Phone: (518) 474-2811, Fax: (518) 474-8590, e-mail: [email protected] Editor: William T. Gunning III, Phone: (419) 383-5256, Fax: (419) 383-3066, e-mail: [email protected] Editor: Stuart McKernan, Phone: (612) 624-6009, Fax: (612) 625-5368, e-mail: [email protected].

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How SIMS microscopy can be used in medicine

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100132649 ◽

1992 ◽

Vol 50 (2) ◽

pp. 1602-1603

Author(s):

Philippe Fragu

Keyword(s):

Mass Spectrometry ◽

Biomedical Applications ◽

Secondary Ion Mass Spectrometry ◽

Chemical Elements ◽

Biological Applications ◽

The Past ◽

Potential Source ◽

Secondary Ion ◽

Chemical Integrity ◽

Scientific Endeavour

The identification, localization and quantification of intracellular chemical elements is an area of scientific endeavour which has not ceased to develop over the past 30 years. Secondary Ion Mass Spectrometry (SIMS) microscopy is widely used for elemental localization problems in geochemistry, metallurgy and electronics. Although the first commercial instruments were available in 1968, biological applications have been gradual as investigators have systematically examined the potential source of artefacts inherent in the method and sought to develop strategies for the analysis of soft biological material with a lateral resolution equivalent to that of the light microscope. In 1992, the prospects offered by this technique are even more encouraging as prototypes of new ion probes appear capable of achieving the ultimate goal, namely the quantitative analysis of micron and submicron regions. The purpose of this review is to underline the requirements for biomedical applications of SIMS microscopy.Sample preparation methodology should preserve both the structural and the chemical integrity of the tissue.

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