scholarly journals Amorphous drug nanoparticle complex as bioavailability enhancement strategy of poorly soluble drugs

2019 ◽  
Author(s):  
Kunn Hadinoto Ong
Keyword(s):  
Poorly Soluble Drugs ◽  
Bioavailability Enhancement ◽  
Poorly Soluble ◽  
Amorphous Drug ◽  
Nanoparticle Complex

Development of an Oral Curcumin Nanocrystal Formulation

2012 ◽  
Vol 3 (4) ◽  
Author(s):  
R. Ravichandran
Keyword(s):  
The Body ◽  
Dissolution Behavior ◽  
Poorly Soluble Drugs ◽  
Solid Dosage Forms ◽  
Bioavailability Enhancement ◽  
Solid Dosage ◽  
Rapid Dissolution ◽  
Poorly Soluble ◽  
Drug Nanocrystal ◽  
Spray Dried

During the last ten years, the formulation of drugs as nanocrystals has rapidly evolved into a mature drug delivery strategy, with currently five products on the market. The major characteristic of these systems is the rapid dissolution velocity, enabling bioavailability enhancement after oral administration. This study describes the preparation of a solid dosage capsule form of spray-dried curcumin nanocrystal and compares its dissolution behavior with market capsule in different media. The aim was to obtain a stable nanocrystal loaded drug capsule with an increased drug saturation solubility and dissolution velocity. The solubility and dissolution experiments were performed to verify the obvious improvement of the dissolution behavior compared with commercial product. Improved dissolution behavior in drug nanocrystal-loaded solid dosage forms should lead to better bioavailability of poorly soluble drugs in the body.

Technological Advancements in Oral Films

2019 ◽  
Vol 9 (01) ◽  
pp. 15-20
Author(s):  
B Pandey ◽  
A B Khan
Keyword(s):  
3D Printing ◽  
Historical Background ◽  
Poorly Soluble Drugs ◽  
Modern Approach ◽  
Poorly Soluble ◽  
Critical Process Parameters ◽  
Biopharmaceutical Properties ◽  
Oral Films ◽  
Hot Melt ◽  
Modern Technologies

The aim of the review was to explore the necessity, advantages and different techniques of oral films for enhancing solubility of poorly soluble drugs with an emphasis on the newer, state-of the art technologies, such as 3D printing and hot-melt extrusion (HME). The historical background of oral films is presented along with the regularly used techniques. The modern approach of quality-by-design (QbD) is unravelled, identifying appropriate critical process parameters (CPP) and applied to oral films. A section is devoted modern technologies such as 3D printing and HME of oral films. Oral films are innovative formulations by which poorly soluble drugs have been founds to give positive results in enhancing their solubility and dissolution characteristics. With modern sophisticated techniques, precise mass production of oral films has been given a thrust. Oral films have better patient compliance, improved biopharmaceutical properties, improved efficacy, and better safety. By applying QbD and implementation of modern technologies the newer generation of oral films are yielding promising results

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