scholarly journals Cystic renal diseases: role of ultrasound. Part I, non-genetic cystic renal diseases

2020 ◽  
Author(s):  
Adnan Kabaalioglu ◽  
Nesrin Gunduz ◽  
Ayse Keven ◽  
Emel Durmaz ◽  
Mine Aslan ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Clinical Data ◽  
Renal Cysts ◽  
The Other ◽  
Renal Diseases ◽  
Intravenous Contrast ◽  
Kidney Cysts ◽  
Pictorial Essay

Kidney cysts are quite common in adults.  Though small simple renal cysts in an adult over 30-40 years of age are not too unusual, however, if the same cysts are seen in a child, and especially if there are additional findings, then several diagnostic possibilities may come to mind. The role of ultrasound, together with the help of intravenous contrast agents and Doppler mode, is very critical in describing the morphologic features and follow-up of the complex or multiple and bilateral renal cysts. Sonographic signs are occasionally specific for diagnosis, but in many cases they should be evaluated together with the other genetic and clinical data to reach a diagnosis.The first part of this pictorial essay includes “non-genetic cystic renal diseases” and the second part will include “genetic cystic renal diseases”.

scholarly journals Cystic renal diseases: role of ultrasound. Part II, genetic cystic renal diseases

2020 ◽  
Author(s):  
Adnan Kabaalioglu ◽  
Nesrin Gunduz ◽  
Ayse Keven ◽  
Emel Durmaz ◽  
Mine Aslan ◽  
...  
Keyword(s):  
Renal Cysts ◽  
The Other ◽  
Renal Diseases ◽  
Intravenous Contrast ◽  
Pictorial Essay ◽  
The Subject ◽  
Key Features

Kidney cysts are quite common in adults. Though small simple renal cysts in an adult over 30-40 years of age are not too unusual, however, if the same cysts are seen in a child, and especially if there are additional findings, then several diagnostic possibilities may come to mind. The role of ultrasound, together with the help of intravenous contrast agents and Doppler mode, are very critical in describing the morphologic features and follow-up of the complex or multiple and bilateral renal cysts. These sonographic signs are occasionally specific for diagnosis, but in many cases sonographic clues should be evaluated together with the other genetic and clinical data to reach diagnosis.The first part of this pictorial essay included the introduction into the subject and the classification of non-genetic cystic renal diseases. The key features for the non-genetic cystic renal diseases are illustrated. In the second part, eye-catching features of genetic cystic renal diseases are demonstrated.

Life Events and Mania

1987 ◽  
Vol 150 (2) ◽  
pp. 235-240 ◽  
Author(s):  
A. Ambelas
Keyword(s):  
Life Events ◽  
Manic Episode ◽  
The Other ◽  
Manic Patients ◽  
Group Comparisons

Fifty patients in their first manic episode were compared retrospectively with groups of (a) manic patients in other than first admissions and (b) acute surgical cases. They were then followed up for 3–8 years. First manic admissions were linked to life events far more frequently – 66%vs20% and 8% respectively for the other groups. Within-group comparisons showed patients with life events were much younger. The link between life events and manic episodes appeared immediate and selective, a view further supported by the findings of the follow-up. Later episodes precipitated by life events seem to require smaller amounts of stress. The possible role of life events in relation to mania is discussed.

scholarly journals MO377HOW THE ITALIAN COVID-19 LOCKDOWN AFFECTED NEFROLOGICAL ACTIVITY IN A LOMBARD CENTER

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Paolo Albrizio ◽  
Silvano Costa ◽  
Annalisa Foschi ◽  
Ivo Angelo Antonio Milani ◽  
Stefano Rindi ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
First Aid ◽  
The Other ◽  
Renal Diseases ◽  
Significant Difference

Abstract Background and Aims Italy and Lombard hospitals particularly, were hard affected by Covid-19 pandemic, mostly during spring and autumn, seasons characterized by two lockdown periods which were however, partly different as rules. During first lockdown in fact, by hospital decision, all ambulatorial activity was closed, including nephrological one. This did not happen during second lockdown period. How the different choices about hospital activity affected nephrological patients is the aim of this study. Method we evaluated all nephrological advices requested by first aid units of our 3 hospitals, all located in Lombardy, to our Nephrology Unit, splitting out data in 3 periods (I lockdown, summer and II lockdown) and comparing with 2019. Data collected were: number of advices requested by day, age, sex, previous regular nephrological follow-up, Covid-19 diagnosis, nephrological diagnosis after nephrological advice and outcome. Results as shown in table 1, during I lockdown period, with hospital decision of suspending our nephrological ambulatorial activity, we suffered an incremented rate of patients approaching local first aid units compared to 2019 same period with an increased rate of acute kidney injury, mostly for dehydration, and with a higher rate of patients requiring hospitalization. All these differences resulted statistically significant vs 2019 same period (figure 1). On the other side, no statically significant difference was found during the other two examined periods, including the II lockdown, while all our ambulatories were fully operating. Conclusion Covid-19 pandemic affected also the nephrological population with an increased rate of first aid units’ accesses, acute kidney injury events and hospitalization comparing to 2019. However, these differences were detectable only during the I lockdown period characterized by the suspension of all ambulatorial activity, including our Unit. The absence of statistically significant differences during summer and primarily during II lockdown period demonstrates the importance of nephrological ambulatorial activity in management of renal diseases and in prevention of acute events.

scholarly journals Exosomes: A Source for New and Old Biomarkers in Cancer

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2566 ◽  
Author(s):  
Mariantonia Logozzi ◽  
Davide Mizzoni ◽  
Rossella Di Raimo ◽  
Stefano Fais
Keyword(s):  
Clinical Oncology ◽  
Extracellular Vesicles ◽  
Clinical Data ◽  
Tumor Biomarkers ◽  
Clinical Use ◽  
Tumor Patients ◽  
Potential Sources ◽  
New Perspective

Clinical oncology needs reliable tumor biomarkers to allow a follow-up of tumor patients who do not necessarily need invasive approaches. To date, the existing biomarkers are not sufficiently reliable, and many of them have generated more problems than facilitating the commitment of clinical oncologists. Over the last decades, a broad family of extracellular vesicles, with size ranging between micro to nano, has been raised as a new hope for potential sources of new tumor biomarkers. However, while knowledge in the field is increasing, we do not currently have definitive information allowing a clinical use of extracellular vesicles in cancer clinics. Recent evidence provides new perspective in clinical oncology, based on data showing that circulating nanovesicles called exosomes may represent a valuable source of tumor biomarkers. In this review, we discuss the existing clinical data supporting a key role of exosomes as a source of tumor biomarkers, including proteins and miRNAs, but also discuss the importance of the expression of known tumor biomarkers when expressed on exosomes.

The Role of Contrast Agents in the Diagnosis of Renal Diseases

2015 ◽  
Vol 44 (4) ◽  
pp. 346-359 ◽  
Author(s):  
Carlos Nicolau ◽  
Iban Aldecoa ◽  
Laura Bunesch ◽  
Carme Mallofre ◽  
Carmen Sebastia
Keyword(s):  
Contrast Agents ◽  
Renal Diseases

The Role of Nephrologist in the Intensive Care Unit

2016 ◽  
Vol 43 (1-3) ◽  
pp. 78-81 ◽  
Author(s):  
Zoltán H. Endre
Keyword(s):  
Chronic Kidney Disease ◽  
Intensive Care Unit ◽  
Acute Kidney Injury ◽  
Intensive Care ◽  
Kidney Injury ◽  
Renal Diseases ◽  
Continuing Care ◽  
Electrolyte Disorders

Participation by nephrologists is needed in most intensive care units, even when such units are ‘closed'. This participation should assist with diagnosis and management of intrinsic and complex renal diseases such as vasculitis, complex metabolic and electrolyte disorders including hyponatremia, and acute kidney injury (AKI) with and without underlying chronic kidney disease (CKD). Early nephrologist involvement will also facilitate transition to continuing care and follow-up after an episode of AKI, but may also assist in avoiding dialysis where treatment is futile. Management of AKI by intensivists should be in partnership with nephrologists to oversight and hopefully to minimize progression to CKD.

Investigating the role of psychogenic shivers in mental health

2019 ◽  
Author(s):  
Felix Schoeller ◽  
Anirudh Krishnakumar
Keyword(s):  
Mental Health ◽  
Clinical Data ◽  
Cognitive Neuroscience ◽  
Clinical Setting ◽  
Large Body ◽  
Assessment Tools ◽  
The Other ◽  
Dsm 5

The presence of shivering and psychogenic shivering in mental health was measured using a compiled database including the DSM-5 and a large body of existing assessment tools and technology. We found results for chills, tremors, and temperature. None of the other shiver-related terms (N=9) yielded any results, which suggests that the role of psychogenic shivering in mental health has been largely understudied by physicians and psychiatrists. Based on the results and the data extracted from a complete database of the literature devoted to psychogenic shivers in cognitive neuroscience, we outline the importance of psychogenic shivering in the assessment of mental health in a clinical setting. We discuss how the tools introduced in this article could be developed further to gather new clinical data about both shivers and health.

Reappraising Others' Negative Emotions as a way to Enhance Coping during the COVID-19 Outbreak

2020 ◽  
Author(s):  
Reout Arbel ◽  
Marlyn Khouri ◽  
Jasmine Sagi ◽  
Noga Cohen
Keyword(s):  
Health Economic ◽  
Emotion Regulation ◽  
Social Life ◽  
Economic Status ◽  
The Other ◽  
New Order ◽  
Coping Efficacy ◽  
Interpersonal Emotion Regulation

The COVID-19 outbreak has forced individuals to adjust to a new order in which their liberties are restricted and uncertainty rules. The current work examined the role of other-focusedemotion regulation (ER) training in enhancing coping efficacy and reducing COVID-19 worries. For that, during the first COVID-19 lockdown in Israel, we trained 59 young individuals to perform other-focused emotion regulation, by reappraising others’ written upsetting events. We compared this procedure to a self-reappraisal training, in which 49 participants were asked to reappraise own upsetting events. Both procedures were performed every other day for three weeks. Participants’ coping efficacy was assessed at the daily level, while worries concerning theCOVID-19 effects on health, economic status, and social life were assessed following the training and at a two-month follow-up. The results demonstrated that other-focused ER surpassed self-focused ER. Specifically, participants in the other-reappraisal group exhibited an increase in coping efficacy across the training sessions and a reduction in COVID-19 worries that persisted two months after the training. These findings highlight the role of interpersonal emotion regulation at times of crisis and social isolation.

Surrogate role of kinetic of perioperative circulating cancer cells (CTCs) in patients with liver metastases (M) of colorectal cancer (CRC).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e21086-e21086
Author(s):  
Lucia Teijeira ◽  
Antonio Viudez ◽  
Maria L Antelo ◽  
Antonio Tarifa ◽  
Cruz Zazpe ◽  
...  
Keyword(s):  
Pathological Response ◽  
The Other ◽  
Kinetic Behavior ◽  
Wild Type ◽  
Cellsearch System ◽  
Future Studies ◽  
Circulating Cancer Cells ◽  
Kras Status

e21086 Background: Kinetic behavior of perioperative CTCs in pts with liver CRC M has been little explored. The aim of this study was to quantified CTCs performance before/just performed and 3 months after radical liver surgery (LS) in pts with CRC M and analyzed the surrogate role of CTCs determinations in DFS and OS. Methods: 7.5 ml of blood were drawn in CellSave tubes. CTCs were isolated and enumerated before/just perfomed and 3 months after radical LS. CTCs were immunomagnetically separated and fluorescently labeled using the CellSearch System (Veridex®/Immunicon Corp.) Results: From February 2009 to December 2011, 35 pts were included. Median age was 61 (45-77); 53.7 % men. Kras status: 66.7% wild-type and 33.3% mutated; 48.6% with synchronous disease. Fong-Criteria (FC) distribution: 31.4% pts with 1 FC, 37.1% pts with 2 FC and 31.4% pts with 3 FC, of whom 60% received neoadjuvant (90% fluoropirimidines-based; 33.3% cetuximab-based; 38% bevacizumab-based) and 77.1% adjuvant treatment. PR and SD were observed in 60% and 40% of pts, respectively. In 70.7% of cases, limited LS were done (68.3% R0, median metastases resected:3) Of the 17 pts analysed, pCR were observed in 2 (12%) with 7 other pts (41%) with major pathological response. With a median of follow-up of 20 months (media 21.3; 95% CI:17.3-41.4) progression disease occurred in 13 pts (55.6% with liver progression), and 5 pts died. Median CTCs was 1 before (0-2: 76%; ≥3: 24%) and just performed surgery (0-2: 65%; ³3: 35%) and 0 in the 3 months determination (0-2: 94.1%; ³3: 5.9%). In the presurgery analysis, DFS was 15 months for the CTCs ≥3 group and 33 months for <3 CTCs (HR: 0.95; 95% CI:0.34-2.64) while in the postsurgery analysis, DFS was 13 months in CTCs ≥3 group and 33 months for <3 CTCs (HR: 1.11; 95% CI:0.37-3.29) CTCs ≥3 group after surgery, OS was 33 months, not having reached in the other groups. Conclusions: There is a marked difference in DFS in favor of pts with CTCs levels 0-2 before and just performed surgery. Our study shows a slight increase in CTCs quantification after LS, instead a significant CTCs decrease was observed after adjuvant therapy. Role of radical LS in kinetic of CTCs should continue to be analysed in future studies.

Postoperative Epileptic Seizures in Children: Is the Brain Incision a Risk Factor?

Neurosurgery ◽  
2017 ◽  
Vol 82 (4) ◽  
pp. 465-472 ◽  
Author(s):  
Luca Massimi ◽  
Domenica Battaglia ◽  
Federico Bianchi ◽  
Simone Peraio ◽  
Elisabetta Peppucci ◽  
...  
Keyword(s):  
Risk Factor ◽  
Surgical Planning ◽  
Epileptic Seizures ◽  
Postoperative Management ◽  
The Other ◽  
Group A ◽  
Group B ◽  
The Brain

Abstract BACKGROUND Postoperative seizures (PSs) after neurosurgical operations are common but little is known about the role of surgical brain incision on their genesis. This topic has not been addressed so far. OBJECTIVE To verify if the corticotomy affects the risk of PSs and postoperative epilepsy (PE) in children. METHODS One hundred forty-three consecutive pediatric cases operated on for supratentorial lesions at the same institution in the last 15 yr have been retrospectively reviewed by dividing them into group A, 68 children who required brain corticotomy mainly for hemispheric tumors, and group B, 75 children treated through extracortical approaches mainly for suprasellar and optic tumors. Patients with possible “epileptic” biases, like preoperative seizures, were excluded. RESULTS No significant differences have been found between group A and B as far as incidence of PSs (11.7% vs 14.5%) and PE (4.5% vs 6.5%), timing, and type of seizures are concerned after a mean 6.8 yr follow-up. The size of corticotomy in group A (&lt;3 cm2 vs &gt;3 cm2) had no impact on epileptogenesis as well as the other variables considered in both groups (age, sex, extent of lesion resection). CONCLUSION This study shows that the surgical cortical “trauma” would not represent a risk factor for PSs and PE. According to the present analysis and the literature, other causes seem to be involved (namely, electrolytic imbalance and brain gliosis). This information is important for preoperative surgical planning and postoperative management. A validation by both adult series and prospective studies is needed.

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