scholarly journals Assessment of hepatic fat content in using quantitative ultrasound measurement of hepatic/renal ratio and hepatic echo-intensity attenuation rate

2020 ◽  
Vol 22 (4) ◽  
pp. 393
Author(s):  
Yun-Sheng Wang ◽  
Gui-Ping Zhang ◽  
Xiao Yang ◽  
Jun Ye ◽  
Yong-Hong Cao ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Quantitative Ultrasound ◽  
Fat Content ◽  
Resonance Spectroscopy ◽  
Echo Intensity ◽  
1H Mrs ◽  
Intensity Attenuation ◽  
Attenuation Rate ◽  
Quantitative Us ◽  
Hepatic Fat

Aims: This study aims to evaluate and validate a simple quantitative ultrasound (US) method for determining the hepatic fat content (HFC) based on the combination of quantitative US hepatic/renal ratio (US-HRR) and quantitative US hepatic echo-intensity attenuation rate (US-HAR) as compared with [1H]-magnetic resonance spectroscopy (1H-MRS).Material and methods: There were a total of 242 subjects recruited in the present study. All subjects were examined for HFC by quantitative US and 1H-MRS methods. The QUS-HRR and QUS-HAR were calculated from ordinary ultrasound images of liver and kidney with a triple modality 3D abdominal phantom using the Image J software.Results: The results found that US-HRR and US-HAR correlated with 1H-MRS HFC (US-HRR: r=0.946, p<0.001; US-HAR: r=0.936, p<0.001). The equation for HFC prediction by using quantitative US was: HFC (%) = 28.965 × US-HRR + 218.045 × US-HAR - 8.892. Subgroup analysis in study subjects with body mass index (BMI) ≥28 showed that quantitative US HFC was associated with 1H-MRS HFC (R2=0.953, p<0.001). Receiver operating characteristic (ROC) analysis observed that the cut-off value of fatty liver diagnosis was 6.71% in using the quantitative US model; the sensitivity and specificity for fatty liver diagnosis were 94.15% and 96.30%, respectively. Variability analysis indicated that there was a relative high degree of consistency in the measurement of HFC with different operators or ultrasonic apparatus.Conclusions: Quantitative US measurement could be regarded as a simple, sensitive tool to accurately assess HFC. It provides a valid alternative to 1H-MRS as an easy, non-invasive option for the precise estimation of HFC in clinical practice.

scholarly journals Sonographic Measurement of the Thickness of Subcutaneous Tissue and Hepatic Echo-Intensity Attenuation Rate in Nonalcoholic Fatty Liver Disease

2020 ◽  
Author(s):  
Abdul Sattar Arif Khammas ◽  
Hasyma Abu Hassan ◽  
Sarah Qahtan Mohammed Salih ◽  
Hayati Kadir Shahar ◽  
Ramlah Mohamed Ibrahim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Quantitative Assessment ◽  
Subcutaneous Tissue ◽  
Echo Intensity ◽  
Intensity Attenuation ◽  
Non Invasive ◽  
Attenuation Rate ◽  
Significant Difference

The most common cause of the chronic liver disease is non-alcoholic fatty liver disease (NAFLD). This study was designed to compare a mean subcutaneous tissue thickness (SCTT) and hepatic echo-intensity attenuation rate (HEIAR) among NAFLD grades. Sonography was carried out on 628 consecutive subjects. The distance between the skin surface and the liver capsule was measured and was labelled the SCTT. Also, the ultrasound of HEIAR was retrospectively quantified on an image archiving. HEIAR was calculated as the difference between mean intensity of echo for two regions of interest (ROIs) in near- and far-fields divided by the distance between these two ROIs multiply by frequency of the probe. Of the 628, 235 subjects were diagnosed with NAFLD. The age range was 45 – 75 years with mean 54.5 ± 6.7 years. There was a significant difference of mean SCTT among NAFLD grades (p<0.001), 65.4% of subjects with SCTT measured ≥ 2.1 cm had NAFLD versus 34.6% of subjects had no NAFLD. Similarly, the differences of mean HEIAR among NAFLD grades were reported to be statistically significant (p<0.001). All of the subjects with HEIAR of 1. 7dB/cm MHz and over had NAFLD. HEIAR is a useful indicator for non-invasive quantitative assessment of NAFLD where sonographically measured HEIAR equal to or over than 1.7 dB/cm MHz makes identifying NAFLD is probably (sensitivity is 59% and specificity is 89%). HEIAR is a useful indicator for non-invasive quantitative assessment of NAFLD.  

scholarly journals Ultrasonography to Quantify Hepatic Fat Content: Validation by 1 H Magnetic Resonance Spectroscopy

Obesity ◽  
2009 ◽  
Vol 17 (12) ◽  
pp. 2239-2244 ◽  
Author(s):  
Mireille A. Edens ◽  
Peter M.A. van Ooijen ◽  
Wendy J. Post ◽  
Mark J.F. Haagmans ◽  
Wisnumurti Kristanto ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Fat Content ◽  
Resonance Spectroscopy ◽  
Content Validation ◽  
Hepatic Fat

scholarly journals External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals

2014 ◽  
Vol 171 (5) ◽  
pp. 561-569 ◽  
Author(s):  
Daniel J Cuthbertson ◽  
Martin O Weickert ◽  
Daniel Lythgoe ◽  
Victoria S Sprung ◽  
Rebecca Dobson ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Fat Content ◽  
Liver Fat ◽  
Resonance Spectroscopy ◽  
Lipid Accumulation Product ◽  
Liver Fat Content ◽  
Fatty Liver Index

Background and aimsSimple clinical algorithms including the fatty liver index (FLI) and lipid accumulation product (LAP) have been developed as surrogate markers for non-alcoholic fatty liver disease (NAFLD), constructed using (semi-quantitative) ultrasonography. This study aimed to validate FLI and LAP as measures of hepatic steatosis, as determined quantitatively by proton magnetic resonance spectroscopy (1H-MRS).MethodsData were collected from 168 patients with NAFLD and 168 controls who had undergone clinical, biochemical and anthropometric assessment. Values of FLI and LAP were determined and assessed both as predictors of the presence of hepatic steatosis (liver fat >5.5%) and of actual liver fat content, as measured by 1H-MRS. The discriminative ability of FLI and LAP was estimated using the area under the receiver operator characteristic curve (AUROC). As FLI can also be interpreted as a predictive probability of hepatic steatosis, we assessed how well calibrated it was in our cohort. Linear regression with prediction intervals was used to assess the ability of FLI and LAP to predict liver fat content. Further validation was provided in 54 patients with type 2 diabetes mellitus.ResultsFLI, LAP and alanine transferase discriminated between patients with and without steatosis with an AUROC of 0.79 (IQR=0.74, 0.84), 0.78 (IQR=0.72, 0.83) and 0.83 (IQR=0.79, 0.88) respectively although could not quantitatively predict liver fat. Additionally, the algorithms accurately matched the observed percentages of patients with hepatic steatosis in our cohort.ConclusionsFLI and LAP may be used to identify patients with hepatic steatosis clinically or for research purposes but could not predict liver fat content.

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