scholarly journals High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Sechang Oh ◽  
Rina So ◽  
Takashi Shida ◽  
Tomoaki Matsuo ◽  
Bokun Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Aerobic Exercise ◽  
Nonalcoholic Fatty Liver Disease ◽  
High Intensity ◽  
Fatty Liver Disease ◽  
Fat Content ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Fat

scholarly journals Imaging techniques for assessing hepatic fat content in nonalcoholic fatty liver disease

2008 ◽  
Vol 7 (3) ◽  
pp. 212-220 ◽  
Author(s):  
Ernesto Roldan-Valadez ◽  
Rafael Favila ◽  
Manuel Martínez-López ◽  
Misael Uribe ◽  
Nahum Méndez-Sánchez
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Imaging Techniques ◽  
Fat Content ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Fat

scholarly journals HDL-apoA-I kinetics in response to 16 wk of exercise training in men with nonalcoholic fatty liver disease

2020 ◽  
Vol 318 (6) ◽  
pp. E839-E847
Author(s):  
Martin B. Whyte ◽  
Fariba Shojaee-Moradie ◽  
Sharaf E. Sharaf ◽  
Daniel J. Cuthbertson ◽  
Graham J. Kemp ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Density Lipoprotein ◽  
Fat Content ◽  
Pool Size ◽  
Interquartile Range ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Fat

Nonalcoholic fatty liver disease (NAFLD) is characterized by low-circulating concentration of high-density lipoprotein cholesterol (HDL-C) and raised triacylglycerol (TAG). Exercise reduces hepatic fat content, improves insulin resistance and increases clearance of very-low-density lipoprotein-1 (VLDL1). However, the effect of exercise on TAG and HDL-C metabolism is unknown. We randomized male participants to 16 wk of supervised, moderate-intensity aerobic exercise ( n = 15), or conventional lifestyle advice ( n = 12). Apolipoprotein A-I (apoA-I) and VLDL-TAG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes (1-[13C]-leucine and 1,1,2,3,3-2H5 glycerol) pre- and postintervention. Participants underwent MRI/spectroscopy to assess changes in visceral fat. Results are means ± SD. At baseline, there were no differences between exercise and control groups for age (52.4 ± 7.5 vs. 52.8 ± 10.3 yr), body mass index (BMI: 31.6 ± 3.2 vs. 31.7 ± 3.6 kg/m2), and waist circumference (109.3 ± 7.5 vs. 110.0 ± 13.6 cm). Percentage of liver fat was 23.8 (interquartile range 9.8–32.5%). Exercise reduced body weight (101.3 ± 10.2 to 97.9 ± 12.2 kg; P < 0.001) and hepatic fat content [from 19.6%, interquartile range (IQR) 14.6–36.1% to 8.9% (4.4–17.8%); P = 0.001] and increased the fraction HDL-C concentration (measured following ultracentrifugation) and apoA-I pool size with no change in the control group. However, plasma and VLDL1-TAG concentrations and HDL-apoA-I fractional catabolic rate (FCR) and production rate (PR) did not change significantly with exercise. Both at baseline (all participants) and after exercise there was an inverse correlation between apoA-I pool size and VLDL-TAG and -apoB pool size. The modest effect of exercise on HDL metabolism may be explained by the lack of effect on plasma and VLDL1-TAG.

scholarly journals Association between diet quality indicators and nonalcoholic fatty liver disease: The FLiO study

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Cristina Galarregui ◽  
M. Angeles Zulet ◽  
Bertha Araceli Marin-Alejandre ◽  
Irene Cantero ◽  
Nora Goodwin ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Diet Quality ◽  
Fatty Liver Disease ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Fat

AbstractIntroductionDietary components are contributing factors in the development of Nonalcoholic fatty liver disease (NAFLD). The glycaemic index (GI), glycaemic load (GL) and total antioxidant capacity (TAC) have been considered potential dietary tools influencing diet–disease relationships. The aim of this study was to evaluate associations of the dietary GI, GL, TAC and insulin resistance (IR) condition with hepatic fat in NAFLD adults.Material and methods: 112 overweight/obese adults with NAFLD (age: 50.8 ± 9 years old) were included in the trial. Dietary intake was assessed by a validated 137-item food frequency questionnaire (FFQ). Anthropometric, glycemic and lipid profiles, fatty liver quantification by magnetic resonance imaging (MRI) and IR measured by the Homeostatic Model Assessment of IR (HOMA-IR) were assessed at baseline. This study was registered as FLiO: Fatty Liver in Obesity study; NCT03183193.Results: The median of liver fat content by MRI was 6.4 (3.8–10.9) in the recruited population. Participants with higher liver fat content showed significantly increased values of glucose, insulin, HbA1c and HOMA-IR than those with lower liver fat content (p < 0.05). Correlation analyses revealed relevant positive associations of hepatic fat with GI (r = 0.17; p = 0.077) and GL (r = 0.19; p = 0.047). Also, a negative association between liver fat content and TAC (r = -0.22; p = 0.023) was found. Linear regression analyses were used to examine the associations of hepatic fat and dietary quality indicators as well as IR adjusted for potential confounders (sex, age and physical activity). The final models showed that HOMA-IR, GI, GL and TAC were able to explain between 22.4 and 22.8 % (p < 0.001) of the variability of liver fat content.DiscussionThe pathophysiology of NAFLD is thought to be associated with dietary determinants that contribute to metabolic dysregulation such as IR, ectopic liver fat deposition and hepatic damage. In accordance with other authors, we suggest that monitoring GI, GL and TAC may be useful approaches for the dietary treatment of NAFLD since they are related to hepatic fat. Additionally, it is important to highlight the essential role of IR in NAFLD as a key mediator in the development of NAFLD. Certainly, findings of the present study revealed a significant association of hepatic fat accumulation and IR.In summary, GI, GL and TAC are potential markers of diet quality, with an impact on susceptible population at hepatic risk.

scholarly journals Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Niraj S. Patel ◽  
Michael R. Peterson ◽  
Grace Y. Lin ◽  
Ariel Feldstein ◽  
Bernd Schnabl ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Fat Content ◽  
Healthy Controls ◽  
Nonalcoholic Fatty Liver ◽  
Pancreatic Fat ◽  
Normal Controls

Background. Ectopic fat deposition in the pancreas and its relationship with hepatic steatosis and insulin resistance have not been compared between patients with nonalcoholic fatty liver disease (NAFLD) and healthy controls.Aim. Using a novel magnetic resonance imaging (MRI) based biomarker, the proton-density-fat-fraction (MRI-PDFF), we compared pancreatic fat content in patients with biopsy-proven NAFLD to healthy controls and determined whether it is associated with insulin resistance and liver fat content.Methods. This nested case-control study was derived from two prospective studies including 43 patients with biopsy-proven NAFLD and 49 healthy controls who underwent biochemical testing and MRI.Results. Compared to healthy controls, patients with NAFLD had significantly higher pancreatic MRI-PDFF (3.6% versus 8.5%,Pvalue <0.001), and these results remained consistent in multivariable-adjusted models including age, sex, body mass index, and diabetes (Pvalue =0.03). We found a strong correlation between hepatic and pancreatic MRI-PDFF (Spearman correlation,P= 0.57,Pvalue <0.001). Participants with increased insulin resistance determined by homeostatic-model-of-insulin-resistance (HOMA-IR) greater than 2.5 had higher pancreatic (7.3% versus 4.5%,Pvalue =0.015) and liver (13.5% versus 4.0%,Pvalue <0.001) MRI-PDFF.Conclusion. Patients with NAFLD have greater pancreatic fat than normal controls. Insulin resistance is associated with liver and pancreatic fat accumulation.

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