Nano-Mechanical Properties of Bioceramic Bone Scaffolds Fabricated at Three Sintering Temperatures

2011 ◽  
Author(s):  
Juan Vivanco ◽  
Josh Slane ◽  
Heidi Ploeg
Keyword(s):  
Donor Site ◽  
Three Dimensional ◽  
Ceramic Materials ◽  
The United States ◽  
Bone Defects ◽  
Donor Site Morbidity ◽  
Autogenous Bone ◽  
Common Procedure ◽  
Bioactive Ceramic ◽  
Autogenous Bone Grafts

Bone grafting is an exceptionally common procedure used to repair bone defects within orthopaedics, craniofacial surgery and dentistry. It is estimated that 2.2 million grafting procedures are performed annually worldwide [1] and maintain a market share of $7 billion in the United States alone [2]. There has been a considerable rise in the interest of using bioactive ceramic materials, such as hydroxyapatite and tricalcium phosphate (TCP), to serve as synthetic replacements for autogenous bone grafts, which suffer from donor site morbidity and limited supply [3]. These ceramic materials (which can be formed into three-dimensional scaffolds) are advantageous due to their inherent biocompatibility, osteoconductivy, osteogenecity and osteointegrity [2].

scholarly journals Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

2013 ◽  
Vol 2013 ◽  
pp. 1-21 ◽  
Author(s):  
Yukihiko Kinoshita ◽  
Hatsuhiko Maeda
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Donor Site ◽  
Three Dimensional ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Donor Site Morbidity ◽  
Autogenous Bone ◽  
Recent Developments

Autogenous bone grafting remains a gold standard for the reconstruction critical-sized bone defects in the craniomaxillofacial region. Nevertheless, this graft procedure has several disadvantages such as restricted availability, donor-site morbidity, and limitations in regard to fully restoring the complicated three-dimensional structures in the craniomaxillofacial bone. The ultimate goal of craniomaxillofacial bone reconstruction is the regeneration of the physiological bone that simultaneously fulfills both morphological and functional restorations. Developments of tissue engineering in the last two decades have brought such a goal closer to reality. In bone tissue engineering, the scaffolds are fundamental, elemental and mesenchymal stem cells/osteoprogenitor cells and bioactive factors. A variety of scaffolds have been developed and used as spacemakers, biodegradable bone substitutes for transplanting to the new bone, matrices of drug delivery system, or supporting structures enhancing adhesion, proliferation, and matrix production of seeded cells according to the circumstances of the bone defects. However, scaffolds to be clinically completely satisfied have not been developed yet. Development of more functional scaffolds is required to be applied widely to cranio-maxillofacial bone defects. This paper reviews recent trends of scaffolds for crania-maxillofacial bone tissue engineering, including our studies.

scholarly journals Autogenous bone augmentation from the zygomatic alveolar crest: a volumetric retrospective analysis in the maxilla

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Irina Kuster ◽  
Livia Osterwalder ◽  
Silvio Valdec ◽  
Bernd Stadlinger ◽  
Maximilian E. H. Wagner ◽  
...  
Keyword(s):  
Gold Standard ◽  
Donor Site ◽  
Bone Defects ◽  
Donor Site Morbidity ◽  
Bone Volume ◽  
Autogenous Bone ◽  
Bone Augmentation ◽  
Maximum Volume ◽  
Alveolar Crest ◽  
Good Access

Abstract Background Autogenous bone augmentation is the gold standard for the treatment of extended bone defects prior to implantation. Bone augmentation from the zygomatic crest is a valuable option with several advantages, but the current literature for this treatment is scant. The aim of this study was to evaluate the increase in bone volume after locoregional bone augmentation using autogenous bone from the zygomatic alveolar crest as well as the complications and success rate. Results Analysis of the augmented bone volume in seven patients showed a maximum volume gain of 0.97 cm3. An average of 0.54 cm3 of autogenous bone (SD 0.24 cm3; median: 0.54 cm3) was augmented. Implantation following bone augmentation was possible in all cases. Complications occurred in three patients. Conclusion The zygomatic alveolar crest is a valuable donor site for autogenous alveolar onlay grafting in a locoregional area such as the maxillary front. Low donor site morbidity, good access, and its suitable convexity make it a beneficial choice for autogenous bone augmentation.

scholarly journals Sole Reconstruction Using Anterolateral Thigh Free Flap: A Review of 4 Cases

1970 ◽  
Vol 2 (3) ◽  
Author(s):  
Parintosa Atmodiwirjo ◽  
Afriyanti Sandhi
Keyword(s):  
Free Flap ◽  
Weight Bearing ◽  
Donor Site ◽  
Three Dimensional ◽  
Free Flaps ◽  
Donor Site Morbidity ◽  
Common Procedure ◽  
Anterolateral Thigh ◽  
Protective Sensation ◽  
And Function

Background: The ideal technique for sole reconstruction should meet such requisite as a durable and comfortable weight-bearing surface, solid anchoring to deep tissue for resistance to shear force and adequate protective sensation. The anterolateral thigh (ALT) perforator free flap provides a large, pliable skin island and sufficient bulk, allowing three-dimensional tailoring to complex defects. The present article is about our experience of sole reconstruction ALT perforator free flap. Patient and Method: Total of 4 flaps in the foot defects was performed in February 2009 to December 2012. We reconstructed soft tissue defects in the sole using ALT free flaps, the complications, aesthetic and function results were monitored. Result: ALT perforator free flap provided stable and durable long-term wound cover in all patients, resulting in early rehabilitation and function outcomes were completely achieved. Complications were few and manageable in all cases. Summary: ALT perforator free flap has become common procedure in many centers around the world. The numerous advantages include stable wound coverage; improve aesthetic and functional outcomes, and minimal donor site morbidity. In our experiences, we found that the use of ALT perforator free flap in sole defect reconstruction, to be technically affordable, reliable and have resulted in excellent outcomes.

scholarly journals Reconstruction of anterior frontal wall and contours defects using bone substitute

2021 ◽  
pp. 34
Author(s):  
Keyword(s):  
Bone Substitute ◽  
Calcium Sulfate ◽  
Donor Site ◽  
Bone Defects ◽  
Autogenous Bone ◽  
Bone Void Filler ◽  
Custom Made ◽  
Cranial Implant ◽  
Bone Void ◽  
Orbital Area

Aim: The aim of this article is to report on the safety and long-term efficacy of Cerament® BoneVoid Filler bone substitute for repairing craniofacial bone defects. Post-traumatic cranioplasty is a complex and challenging procedure for all maxillo-craniofacial surgeons and neurosurgeons, especially when repairing large areas. The standard criterion for repairing small cranial defects is the use autogenous bone from the iliac crest or split calvarial grafts. Autogenous grafts may result in donor-site morbidity, increased surgical time, reabsorption, blood loss, and longer recovery time . Alloplastic materials used for bone repair, such as methyl methacrylate, hydroxyapatite, titanium, or porous polyethylene, are expected to have optimal properties, including easy adaptation, biocompatibility, ingrowth of new tissue, stability of shape, and low rate of reabsorption. A cranial implant should be easily shaped and positioned, allowing easy tissue growth. In very wide cranium defects the new technology is a custom made cranial implant constructed three-dimensionally with different types of materials. However, this procedure is very expensive with various infection rates depending on the kind of material used and on the chemicophysical composition of the implant. Methods: The authors report the case of a 50-year-old man with a severe deformity of the forehead-supra orbital area as a result of a previous complex fronto-facial trauma treated in an emergency Unit. Secondary correction and reconstruction of the residual deformities were performed by using Cerament® Bone Void Filler, an alloplastic biphasic material, composed of 40% hydroxyapatite, 60% calcium sulfate and the radio-contrast agent iohexol. The unique ratio of hydroxyapatite and calcium sulfate is designed to enable Cerament to resorb at the same rate that bone forms. Calcium sulfate acts as a resorbable carrier for hydroxyapatite which is highly osteoconductive, promoting bone ingrowth.It seems to be a promising bone graft substitute in the management of bony irregularities in the fronto-orbital area. Conclusion: The patient was first hospitalized as the result of a serious craniofacial trauma. One year after the first emergency cranio-orbital reconstructive operation, a marked deformity of the frontal region appeared with a “grid effect” due to the inadequate plate-bony fixation of the fractures applied during the first bony recomposition and because it was not as rigid as it should have been . A secondary surgery for deformity correction was performed. The hardware was totally removed and the bony deformity smoothed, reshaped, covered and filled using Cerament® Bone Void Filler, a biomaterial. The patient recovered with a satisfactory cranium-forehead shape, no complications, and complete disappearance of a frowning look of the fronto-orbital region. Recently, increased use of bone substitutes in the reconstruction of bone defects has been fuelled by donor site complications associated with autologous bone harvesting. Cerament® BoneVoid Filler is a biphasic and injectable bone substitute that has a highly compressive strength and the ability to promote cancellous bone healing

Effects of Sterilization Techniques and Culture Time on the Creep of Collagenous Ligament Analogues

2002 ◽  
Author(s):  
Darryl A. Dickerson ◽  
Kay C. Dee ◽  
Glen A. Livesay
Keyword(s):  
Cruciate Ligament ◽  
Donor Site ◽  
Critical Role ◽  
The United States ◽  
Donor Site Morbidity ◽  
Joint Stability ◽  
Acl Injuries ◽  
Anterior Cruciate ◽  
Active Patients

Every year, approximately 200,000 anterior cruciate ligament (ACL) injuries occur in the United States; of these cases, 60,000–75,000 patients undergo ACL reconstruction [1]. The ACL plays a critical role in knee stability; however, it possesses little inherent capacity for healing. Although reconstruction is often used in active patients, issues such as donor site morbidity and long term joint stability have motivated interest in tissue-engineered ligament analogues.

scholarly journals Bone-Forming Capabilities of a Newly Developed NanoHA Composite Alloplast Infused with Collagen: A Pilot Study in the Sheep Mandible

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Charles Marin ◽  
Ryo Jimbo ◽  
Fabio Cesar Lorenzoni ◽  
Lukasz Witek ◽  
Hellen Teixeira ◽  
...  
Keyword(s):  
Bone Ingrowth ◽  
Donor Site ◽  
Three Dimensional ◽  
Polyglycolic Acid ◽  
Autogenous Bone ◽  
Graft Material ◽  
Resorption Rate ◽  
Experimental Block ◽  
The Status

Lateral or vertical bone augmentation has always been a challenge, since the site is exposed to constant pressure from the soft tissue, and blood supply only exists from the donor site. Although, for such clinical cases, onlay grafting with autogenous bone is commonly selected, the invasiveness of the secondary surgical site and the relatively fast resorption rate have been reported as a drawback, which motivated the investigation of alternative approaches. This study evaluated the bone-forming capability of a novel nanoHA alloplast infused with collagen graft material made from biodegradable polylactic acid/polyglycolic acid versus a control graft material with the same synthesized alloplast without the nanoHA component and collagen infiltration. The status of newly formed bone and the resorption of the graft material were evaluated at 6 weeksin vivohistologically and three dimensionally by means of 3D microcomputed tomography. The histologic observation showed that newly formed bone ingrowth and internal resorption of the block were observed for the experimental blocks, whereas for the control blocks less bone ingrowth occurred along with lower resorption rate of the block material. The three-dimensional observation indicated that the experimental block maintained the external geometry, but at the same time successfully altered the graft material into bone. It is suggested that the combination of numerous factors contributed to the bone ingrowth and the novel development could be an alternative bone grafting choice.

scholarly journals One injection for a great projection: a quick and simple procedure for nipple reconstruction

2021 ◽  
Vol 48 (2) ◽  
pp. 179-184
Author(s):  
Sara Tanini ◽  
Sara Calabrese ◽  
Elena Lucattelli ◽  
Giulia Lo Russo
Keyword(s):  
Simple Procedure ◽  
Donor Site ◽  
Three Dimensional ◽  
Donor Site Morbidity ◽  
Single Step ◽  
Nipple Reconstruction ◽  
Breast Cancer Patients ◽  
Reconstruction Process ◽  
Areolar Complex ◽  
Wound Matrix

Women attach great importance to the presence of a three-dimensional nipple upon completion of the breast reconstruction process. To meet patients’ expectations, nipple-areolar complex reconstruction should achieve symmetry in position, size, shape, texture, and color, as well as minimizing donor-site morbidity. However, it is well known that regardless of the reconstructive technique, loss of nipple projection can be reasonably expected. We developed and evaluated a quick, simple, and innovative technique using injectable Integra Flowable Wound Matrix to increase nipple projection after reconstruction. Twenty breast cancer patients who underwent nipple reconstruction resulting in unsatisfactory projection were enrolled in our retrospective study. Nipple projection was measured at the time of surgery and after 6 and 12 months. A visual analogue scale was used to assess patients’ satisfaction. Our technique yielded reliable results in terms of the long-lasting maintenance of nipple projection. This method is high-priced, but cost-effective, since one kit may suffice for three patients. Furthermore, our patients were very appreciative of this technique as a single-step, minimally invasive, painless procedure with no reported necessity of re-intervention.

scholarly journals A Patient-Matched Entire First Metacarpal Prosthesis in Treatment of Giant Cell Tumor of Bone

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Thipachart Punyaratabandhu ◽  
Boonrat Lohwongwatana ◽  
Chedtha Puncreobutr ◽  
Arkaphat Kosiyatrakul ◽  
Puwadon Veerapan ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Hand Function ◽  
Donor Site ◽  
Bone Grafts ◽  
Cell Tumor ◽  
High Rate ◽  
Autogenous Bone ◽  
Aesthetic Appearance ◽  
Autogenous Bone Grafts

Giant cell tumor of the bones occurring in the first metacarpals frequently requires entire metacarpal resection due to the aggressive nature and high rate of recurrence. Bone reconstruction can be performed with autogenous bone grafts. Here we describe a new technique of reconstruction using a patient-matched three-dimensional printed titanium first metacarpal prosthesis. This prosthesis has a special design for ligament reconstruction in the proximal and distal portions. Good hand function and aesthetic appearance were maintained at a 24-month follow-up visit. This reconstructive technique can avoid donor-site complications and spare the autogenous bone grafts for revision options.

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