scholarly journals A Patient-Matched Entire First Metacarpal Prosthesis in Treatment of Giant Cell Tumor of Bone

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Thipachart Punyaratabandhu ◽  
Boonrat Lohwongwatana ◽  
Chedtha Puncreobutr ◽  
Arkaphat Kosiyatrakul ◽  
Puwadon Veerapan ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Hand Function ◽  
Donor Site ◽  
Bone Grafts ◽  
Cell Tumor ◽  
High Rate ◽  
Autogenous Bone ◽  
Aesthetic Appearance ◽  
Autogenous Bone Grafts

Giant cell tumor of the bones occurring in the first metacarpals frequently requires entire metacarpal resection due to the aggressive nature and high rate of recurrence. Bone reconstruction can be performed with autogenous bone grafts. Here we describe a new technique of reconstruction using a patient-matched three-dimensional printed titanium first metacarpal prosthesis. This prosthesis has a special design for ligament reconstruction in the proximal and distal portions. Good hand function and aesthetic appearance were maintained at a 24-month follow-up visit. This reconstructive technique can avoid donor-site complications and spare the autogenous bone grafts for revision options.

scholarly journals Medical Therapy of Giant Cell Tumor of Bone

2021 ◽  
Author(s):  
Raquel Lopes-Brás ◽  
Isabel Fernandes ◽  
Sandra Casimiro ◽  
Luís Costa
Keyword(s):  
Local Recurrence ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Early Stage ◽  
Human Monoclonal Antibody ◽  
Bone Destruction ◽  
Cell Tumor ◽  
High Rate ◽  
High Local Recurrence Rate ◽  
Key Factor

Giant cell tumor of bone (GCTB) is mostly a benign disease of the bone, although with high local recurrence rate and potential for metastatic spread, namely to the lungs. It is also a locally aggressive tumor, associated with severe morbidity and functional impairment due to bone destruction. Treatment is therefore required and should be offered at an early stage to allow complete resection, minimizing functional sequelae and local recurrence. Surgical resection is the mainstay of treatment, often followed by intralesional adjuvant therapy. GCTB has a particular biology, in which RANKL represents a key factor in tumor pathogenesis, thus making this molecule a valuable therapeutic target. Monthly administration of denosumab, a fully human monoclonal antibody directed against RANKL, has been studied in several clinical trials and shown a high rate of local control with favorable safety profile. In this chapter, current medical management, ongoing studies, and future directions in GCTB will be discussed.

scholarly journals Caso Clínico: Uso de Aloinjerto Óseo Estructural en Tumor de Células Gigantes de Fémur

2018 ◽  
Vol 10 (2) ◽  
pp. 184-188
Author(s):  
Cristhian Xavier Avilés Chamaidan ◽  
ristian Miguel Barrera Carmona ◽  
José Eddy Márquez Jervi ◽  
Luis Alfredo Moreira del Pozo ◽  
Jorge Luis Armijos Vélez
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Distal Femur ◽  
Functional Limitation ◽  
Cost Benefit ◽  
Bone Allograft ◽  
Functional Results ◽  
Cell Tumor ◽  
Autogenous Bone ◽  
En Bloc

BACKGROUND: Bone giant cell tumor (GCT) is one of the least frequent, most controversial and least predictable tumors in its behavior. We present a case of GCT in the lower limb, which implied the distal femur. The diagnosis required a previous biopsy before proceeding with its en bloc resection, and treatment based on bone allograft. CASE REPORT: Male patient of 43 years of age, mestizo, with no relevant personal or family history. He went to the oncology orthopedics outpatient clinic for presenting a hard and painful mass with gradual increase in size at the level of the right knee, deformity, functional limitation and crepitus in that region, which is why he attends his assessment. EVOLUTION: The patient underwent a lesion biopsy at the level of the distal femur with a pathological anatomy report of giant cell tumor. Bone resection was performed at the tumor level and treatment was performed by allografting the bone structural allograft. A 2-year follow-up was performed and a score of 14/15 according to the Makin scale was obtained as functional results. Osteointegration of the graft to autogenous bone was also evidenced. Excellently at 15 months. We did not find infection, graft resorption or fatigue of the material. CONCLUSIONS: Limb preservation surgery represented by structural allografts is a favorable technique with adequate functionality and osteoingration, increasing the life expectancy of our patients and future revision possibilities. Avoiding amputations, arthrodesis or tumor prosthesis whose cost benefit with the subsequent years end up being high and deteriorating the quality of life in the patient.

scholarly journals Giant Cell Tumor on Tendon Sheath of the Hand: The Incidence of Recurrence, Functional Outcomes and a Literature Review

2020 ◽  
Vol 5 (12) ◽  
pp. 638-644
Author(s):  
Kastanis G ◽  
Bachlitzanaki M ◽  
Kapsetakis P ◽  
Christoforidis C ◽  
Chaniotakis C ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Functional Outcomes ◽  
Hand Function ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Dash Score ◽  
A2 Pulley ◽  
Quick Dash

Giant Cell Tumor on Tendon Sheath (GCTTS) of the hand is a benign nodular tumor originated from tendon sheath of the tendons and the joints and is the second most common soft tissue tumor of the hand after ganglion cyst. The aim of this study is to evaluate 79 cases of giant cell tumor of tendon sheath of the hand and to analyze the postoperative functional outcomes and recurrence rate of the tumor in a mean period of five years follow up. Material and Methods: Fifty five subjects were females and twenty four males with an average age of 38,8 years-old (range23-65 years old) were included in this study. The most frequent location of tumor was the index finger (32/79 patients, 40,5%). The majority of patients was presented in outpatient’s clinic for a painless swelling on volar side of the digit, while only 13(16,45%) patients presented for painful mass and numbness of the digit in 7(8,9%) cases. All cases were categorized by Al-Qattan classification system with type I lesion in 51(64,5 %) cases and type II in 28(35,5 %) cases. Dimension of tumors macroscopically varied from 0,4cm to 5 cm. In 12 cases we reconstructed the A2 pulley to avoid bowstring deformity and eventual postoperative loss of hand function. In 12 cases we reconstructed the A2 pulley to avoid bowstring deformity and eventual postoperative loss of hand function. 8 patents with bone erosion underwent postoperatively complementary local radiotherapy. A standard protocol of rehabilitation was performed in all patients. Results: Results were evaluated according to complications, range of motion, Quick Dash Score and functional satisfaction of patients in a mean follow-up of 49 months. Two major complications presented in this study: 5 cases with transitional neuroapraxia and 6 cases with recurrence of the tumor with a mean of postsurgical period 14,8 months. Finally at last assessment the mean Quick Dash Score was 4,5 (range from 0-11,4) the range of motion was fully recovered in 73 patients while patient’s satisfaction rated from “very satisfied” in 58(73,4%) cases, “satisfied” in 17(21,5) and “dissatisfied” in 4(5,1%) patients. Conclusions: Giant cell tumor of tendon sheath of the hand is a common tumor which presents a high incidence of recurrence in different populations of patients. The goal of treatment is to reduce the recurrence rate and restore a functional hand. The operation procedure should be well planned preoperatively, the tumor must excised en block, dissection must be under surgical loop and must be emphasized to remove satellite lesion while when patients present increased risk factors or inadequate excision of the mass, postoperative radiotherapy is performed.

scholarly journals Autogenous maxillary and mandibular bone grafts – review of the literature

2015 ◽  
Vol 61 (1) ◽  
pp. 96-99
Author(s):  
Alexandru Poll ◽  
◽  
Dan Ionuţ Sălăvăstru ◽  
Roxana Ivaşcu ◽  
Lavinia Buţincu ◽  
...  
Keyword(s):  
Donor Site ◽  
Third Molar ◽  
Bone Grafts ◽  
Autogenous Bone ◽  
Bone Harvesting ◽  
First Choice ◽  
Mandibular Third Molar ◽  
Scientific Papers ◽  
Oral Implantology ◽  
Autogenous Bone Grafts

This study is a review of the specialised literature regarding the intraoral autogenous bone grafts used in oral implantology. 382 abstracts of scientific papers, 71 full-text scientific articles and 9 specialized books, out of which 113 included in the references, were studied. The area behind the mandibular third molar, the posterior buccal area of the mandible body and the mandibular symphysis are the most frequently used sites for intraoral block bone harvesting. The mandible should be the first choice in the intraoral donor site selection for peri-implant augmentation, if the quantity of bone that is going to be harvested is considered to be enough.

Bilateral Mirror-Symmetrical Giant Cell Tumor of the Tendon Sheath in the Foot and Ankle: A Case Report

2021 ◽  
Vol 60 (1) ◽  
pp. 163-166
Author(s):  
Naji S. Madi ◽  
Said Saghieh ◽  
Ahmad Salah Naja ◽  
Rachid K. Haidar
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Foot And Ankle
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