A Bioactive Peptide Grafted Scaffold for Peripheral Nerve Regeneration

2011 ◽  
Author(s):  
Shirley Masand ◽  
Jian Chen ◽  
Melitta Schachner ◽  
David I. Shreiber
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nervous System ◽  
Functional Recovery ◽  
Peripheral Nerve Regeneration ◽  
Scar Tissue ◽  
Mechanical Support ◽  
Severity Of Injury ◽  
Fibrous Scar Tissue

Despite this innate regenerative potential of the peripheral nervous system, functional recovery often remains incomplete, especially as the severity of injury increases. This has been attributed to a number of sources including the ingrowth of fibrous scar tissue, lack of mechanical support for emerging neurites, and the malrouted reinnervation of neurites towards inappropriate targets. While research in the field is broad, it is generally accepted that an optimal nerve guidance conduit to encourage regeneration should include both biological and mechanical support for emerging neurites and glia.

scholarly journals The Role of Dietary Nutrients in Peripheral Nerve Regeneration

2021 ◽  
Vol 22 (14) ◽  
pp. 7417
Author(s):  
Marwa El Soury ◽  
Benedetta Elena Fornasari ◽  
Giacomo Carta ◽  
Federica Zen ◽  
Kirsten Haastert-Talini ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nervous System ◽  
Peripheral Nerve Regeneration ◽  
Satisfactory Outcome ◽  
Dietary Nutrients ◽  
Correct Function ◽  
Motorcycle Accidents

Peripheral nerves are highly susceptible to injuries induced from everyday activities such as falling or work and sport accidents as well as more severe incidents such as car and motorcycle accidents. Many efforts have been made to improve nerve regeneration, but a satisfactory outcome is still unachieved, highlighting the need for easy to apply supportive strategies for stimulating nerve growth and functional recovery. Recent focus has been made on the effect of the consumed diet and its relation to healthy and well-functioning body systems. Normally, a balanced, healthy daily diet should provide our body with all the needed nutritional elements for maintaining correct function. The health of the central and peripheral nervous system is largely dependent on balanced nutrients supply. While already addressed in many reviews with different focus, we comprehensively review here the possible role of different nutrients in maintaining a healthy peripheral nervous system and their possible role in supporting the process of peripheral nerve regeneration. In fact, many dietary supplements have already demonstrated an important role in peripheral nerve development and regeneration; thus, a tailored dietary plan supplied to a patient following nerve injury could play a non-negotiable role in accelerating and promoting the process of nerve regeneration.

scholarly journals Local administration of icariin contributes to peripheral nerve regeneration and functional recovery

2015 ◽  
Vol 10 (1) ◽  
pp. 84 ◽  
Author(s):  
Yu-hui Kou ◽  
Bao-guo Jiang ◽  
Bo Chen ◽  
Su-ping Niu ◽  
Zhi-yong Wang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Peripheral Nerve Regeneration ◽  
Local Administration

scholarly journals Author Correction: Label-Free Imaging of Tissue Architecture during Axolotl Peripheral Nerve Regeneration in Comparison to Functional Recovery

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ortrud Uckermann ◽  
Joana Hirsch ◽  
Roberta Galli ◽  
Jonas Bendig ◽  
Robert Later ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Peripheral Nerve Regeneration ◽  
Label Free ◽  
Tissue Architecture

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Peripheral nerve injury therapeutics, including electrical stimulation, stem cell treatments, and synthetic neural scaffolds, have shown promising preclinical and even clinical results with potential regenerative treatment

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Stem Cell ◽  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Peripheral Nerve Regeneration ◽  
Clinical Results ◽  
Preclinical Research ◽  
Cell Therapies ◽  
Nerve Recovery

In the U.S., peripheral nerve injuries (PNI) harm about 22 million people. The most frequent causes and types of PNI vary by demography (civilians vs. military, geography/country). After crush injuries, functional recovery is better than after transections, and better after distal injuries than proximal ones. Despite advancements in microsurgical treatments, severe PNIs remain connected to slow recovery. This review highlights new peripheral nerve regeneration approaches (e.g. electrical stimulation, cell therapies), which may lead to a shift in PNI therapeutic paradigms in conjunction with neurotrophic agents and breakthroughs in bioscaffold engineering. It also examines how synthetic neural scaffolds can aid with peripheral nerve recovery, as well as the next generation of biomimetic neural scaffolding that can aid in tissue regeneration. Neurotrophic factor-enriched neural scaffolds, stem cell treatments, and electrical stimulation have shown promising preclinical and even clinical results. The future of peripheral nerve regeneration is bright, since a combination of the aforementioned treatments may have a synergistic impact on nerve regeneration and functional recovery in patients with PNI. Stem cell technology is improving and evolving, and it has been explored through a number of methods in preclinical research for peripheral nerve regeneration. Electrical stimulation is another interesting potential treatment for PNI that may be used to stimulate axon regeneration.

Sign in / Sign up

Export Citation Format

Share Document