Cultured peripheral nervous system cells support peripheral nerve regeneration through tubes in the absence of distal nerve stump

1985 ◽  
Vol 14 (4) ◽  
pp. 393-401 ◽  
Author(s):  
H. D. Shine ◽  
P. G. Harcourt ◽  
R. L. Sidman
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nervous System ◽  
Peripheral Nerve Regeneration ◽  
Nerve Stump ◽  
Distal Nerve

scholarly journals Distinct VIP and PACAP Functions in the Distal Nerve Stump During Peripheral Nerve Regeneration

2019 ◽  
Vol 13 ◽  
Author(s):  
Patricia K. Woodley ◽  
Qing Min ◽  
Yankun Li ◽  
Nina F. Mulvey ◽  
David B. Parkinson ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Nerve Stump ◽  
Distal Nerve

Blind-ended semipermeable guidance channels support peripheral nerve regeneration in the absence of a distal nerve stump

1988 ◽  
Vol 454 (1-2) ◽  
pp. 179-187 ◽  
Author(s):  
P. Aebischer ◽  
V. Gue´nard ◽  
S.R. Winn ◽  
R.F. Valentini ◽  
P.M. Galletti
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Nerve Stump ◽  
Distal Nerve ◽  
Guidance Channels

A Bioactive Peptide Grafted Scaffold for Peripheral Nerve Regeneration

2011 ◽  
Author(s):  
Shirley Masand ◽  
Jian Chen ◽  
Melitta Schachner ◽  
David I. Shreiber
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nervous System ◽  
Functional Recovery ◽  
Peripheral Nerve Regeneration ◽  
Scar Tissue ◽  
Mechanical Support ◽  
Severity Of Injury ◽  
Fibrous Scar Tissue

Despite this innate regenerative potential of the peripheral nervous system, functional recovery often remains incomplete, especially as the severity of injury increases. This has been attributed to a number of sources including the ingrowth of fibrous scar tissue, lack of mechanical support for emerging neurites, and the malrouted reinnervation of neurites towards inappropriate targets. While research in the field is broad, it is generally accepted that an optimal nerve guidance conduit to encourage regeneration should include both biological and mechanical support for emerging neurites and glia.

scholarly journals The Role of Dietary Nutrients in Peripheral Nerve Regeneration

2021 ◽  
Vol 22 (14) ◽  
pp. 7417
Author(s):  
Marwa El Soury ◽  
Benedetta Elena Fornasari ◽  
Giacomo Carta ◽  
Federica Zen ◽  
Kirsten Haastert-Talini ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nervous System ◽  
Peripheral Nerve Regeneration ◽  
Satisfactory Outcome ◽  
Dietary Nutrients ◽  
Correct Function ◽  
Motorcycle Accidents

Peripheral nerves are highly susceptible to injuries induced from everyday activities such as falling or work and sport accidents as well as more severe incidents such as car and motorcycle accidents. Many efforts have been made to improve nerve regeneration, but a satisfactory outcome is still unachieved, highlighting the need for easy to apply supportive strategies for stimulating nerve growth and functional recovery. Recent focus has been made on the effect of the consumed diet and its relation to healthy and well-functioning body systems. Normally, a balanced, healthy daily diet should provide our body with all the needed nutritional elements for maintaining correct function. The health of the central and peripheral nervous system is largely dependent on balanced nutrients supply. While already addressed in many reviews with different focus, we comprehensively review here the possible role of different nutrients in maintaining a healthy peripheral nervous system and their possible role in supporting the process of peripheral nerve regeneration. In fact, many dietary supplements have already demonstrated an important role in peripheral nerve development and regeneration; thus, a tailored dietary plan supplied to a patient following nerve injury could play a non-negotiable role in accelerating and promoting the process of nerve regeneration.

scholarly journals Meta-Analysis Reveals Transcription Factor Upregulation in Cells of Injured Mouse Sciatic Nerve

2021 ◽  
Vol 15 ◽  
Author(s):  
Mingchao Li ◽  
Matthew C. Banton ◽  
Qing Min ◽  
David B. Parkinson ◽  
Xinpeng Dun
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Peripheral Nerve Regeneration ◽  
Data Sets ◽  
Sequencing Data ◽  
Nerve Stump ◽  
Post Injury ◽  
Distal Nerve

Following peripheral nerve injury, transcription factors upregulated in the distal nerve play essential roles in Schwann cell reprogramming, fibroblast activation and immune cell function to create a permissive distal nerve environment for axonal regrowth. In this report, we first analysed four microarray data sets to identify transcription factors that have at least twofold upregulation in the mouse distal nerve stump at day 3 and day 7 post-injury. Next, we compared their relative mRNA levels through the analysis of an available bulk mRNA sequencing data set at day 5 post-injury. We then investigated the expression of identified TFs in analysed single-cell RNA sequencing data sets for the distal nerve at day 3 and day 9 post-injury. These analyses identified 55 transcription factors that have at least twofold upregulation in the distal nerve following mouse sciatic nerve injury. Expression profile for the identified 55 transcription factors in cells of the distal nerve stump was further analysed on the scRNA-seq data. Transcription factor network and functional analysis were performed in Schwann cells. We also validated the expression pattern of Jun, Junb, Runx1, Runx2, and Sox2 in the mouse distal nerve stump by immunostaining. The findings from our study not only could be used to understand the function of key transcription factors in peripheral nerve regeneration but also could be used to facilitate experimental design for future studies to investigate the function of individual TFs in peripheral nerve regeneration.

scholarly journals Bioactive Glasses and Glass/Polymer Composites for Neuroregeneration: Should We Be Hopeful?

2020 ◽  
Vol 10 (10) ◽  
pp. 3421 ◽  
Author(s):  
Saeid Kargozar ◽  
Masoud Mozafari ◽  
Maryam Ghenaatgar-Kasbi ◽  
Francesco Baino
Keyword(s):  
Tissue Engineering ◽  
Nervous System ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Bone Repair ◽  
Peripheral Nerve Regeneration ◽  
Bioactive Glasses ◽  
Novel Technologies ◽  
Cell Functions

Bioactive glasses (BGs) have been identified as highly versatile materials in tissue engineering applications; apart from being used for bone repair for many years, they have recently shown promise for the regeneration of peripheral nerves as well. They can be formulated in different shapes and forms (micro-/nanoparticles, micro-/nanofibers, and tubes), thus potentially meeting the diverse requirements for neuroregeneration. Mechanical and biological improvements in three-dimensional (3D) polymeric scaffolds could be easily provided by adding BGs to their composition. Various types of silicate, borate, and phosphate BGs have been examined for use in neuroregeneration. In general, BGs show good compatibility with the nervous system compartments both in vitro and in vivo. Functionalization and surface modification plus doping with therapeutic ions make BGs even more effective in peripheral nerve regeneration. Moreover, the combination of BGs with conductive polymers is suggested to improve neural cell functions at injured sites. Taking advantage of BGs combined with novel technologies in tissue engineering, like 3D printing, can open new horizons in reconstructive approaches for the nervous system. Although there are great potential opportunities in BG-based therapies for peripheral nerve regeneration, more research should still be performed to carefully assess the pros and cons of BGs in neuroregeneration strategies.

scholarly journals Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 41
Author(s):  
Fengshi Zhang ◽  
Meng Zhang ◽  
Songyang Liu ◽  
Ci Li ◽  
Zhentao Ding ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Physical Properties ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Functional Restoration ◽  
Nerve Tissue ◽  
Alternative Methods ◽  
Electrically Conductive ◽  
Conductive Hydrogels

Peripheral nerve injury (PNI) occurs frequently, and the prognosis is unsatisfactory. As the gold standard of treatment, autologous nerve grafting has several disadvantages, such as lack of donors and complications. The use of functional biomaterials to simulate the natural microenvironment of the nervous system and the combination of different biomaterials are considered to be encouraging alternative methods for effective tissue regeneration and functional restoration of injured nerves. Considering the inherent presence of an electric field in the nervous system, electrically conductive biomaterials have been used to promote nerve regeneration. Due to their singular physical properties, hydrogels can provide a three-dimensional hydrated network that can be integrated into diverse sizes and shapes and stimulate the natural functions of nerve tissue. Therefore, conductive hydrogels have become the most effective biological material to simulate human nervous tissue’s biological and electrical characteristics. The principal merits of conductive hydrogels include their physical properties and their electrical peculiarities sufficient to effectively transmit electrical signals to cells. This review summarizes the recent applications of conductive hydrogels to enhance peripheral nerve regeneration.

scholarly journals New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies

2021 ◽  
Vol 22 (24) ◽  
pp. 13380
Author(s):  
Polina Klimovich ◽  
Kseniya Rubina ◽  
Veronika Sysoeva ◽  
Ekaterina Semina
Keyword(s):  
Nervous System ◽  
Nerve Regeneration ◽  
Peripheral Nervous System ◽  
Peripheral Nerve Regeneration ◽  
Treatment Strategies ◽  
Cellular Mechanisms ◽  
Functional Regeneration ◽  
New Treatment ◽  
Cell Migration And Proliferation ◽  
Serious Injuries

Topical advances in studying molecular and cellular mechanisms responsible for regeneration in the peripheral nervous system have highlighted the ability of the nervous system to repair itself. Still, serious injuries represent a challenge for the morphological and functional regeneration of peripheral nerves, calling for new treatment strategies that maximize nerve regeneration and recovery. This review presents the canonical view of the basic mechanisms of nerve regeneration and novel data on the role of exosomes and their transferred microRNAs in intracellular communication, regulation of axonal growth, Schwann cell migration and proliferation, and stromal cell functioning. An integrated comprehensive understanding of the current mechanistic underpinnings will open the venue for developing new clinical strategies to ensure full regeneration in the peripheral nervous system.

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