A Reliability-Based Method for Determining Design Ice Loads on Offshore Structures

2002 ◽  
Author(s):  
X. Wu ◽  
A. T. Wang ◽  
C. E. Heuer ◽  
T. D. Ralston ◽  
G. F. Davenport ◽  
...  
Keyword(s):  
Rational Design ◽  
Offshore Structures ◽  
Type I ◽  
Type Ii ◽  
General Applicability ◽  
Ice Load ◽  
Research Company ◽  
Ice Loads ◽  
Offshore Development ◽  
Systematic Framework

This paper describes a reliability-based methodology that has been developed at ExxonMobil Upstream Research Company (URC) for determining rational design ice loads on offshore structures. The URC methodology provides a systematic framework to account for Type I (aleatory) and Type II (epistemic) uncertainties in assessing global probabilistic ice hazards. Specifically, a logic-tree based approach is developed to model Type II uncertainties in the assessment of ice hazards. Although the method has general applicability, the present work considers a wide, vertical-sided, gravity-based structure (GBS) in a dynamic, annual ice environment. Both FORM/SORM methods and Monte Carlo simulation are used in the analyses. Results obtained from this reliability-based approach indicate that the modeling of Type II uncertainties plays a significant role in quantifying the ice hazards for determining the design ice load. Further, this effort may potentially reduce over-conservatism in typical deterministic ice load calculations. The probabilistic methodology developed in this study has broad applicability and can provide a rational framework for calculating design ice loads on other types of structures for arctic offshore development.

Methodology to Evaluate Sea Ice Loads for Seasonal Operations

2015 ◽  
Author(s):  
Jan Thijssen ◽  
Mark Fuglem
Keyword(s):  
Sea Ice ◽  
Offshore Structures ◽  
Ice Thickness ◽  
Safety Level ◽  
Site Specific ◽  
Design Load ◽  
Ice Load ◽  
Ice Conditions ◽  
Design Loads ◽  
Ice Loads

Offshore structures designed for operation in regions where sea ice is present will include a sea ice load component in their environmental loading assessment. Typically ice loads of interest are for 10−2, 10−3 or 10−4 annual probability of exceedance (APE) levels, with appropriate factoring to the required safety level. The ISO 19906 standard recommends methods to determine global sea ice loads on vertical structures, where crushing is the predominant failure mode. Fitted coefficients are proposed for both Arctic and Sub-Arctic (e.g. Baltic) conditions. With the extreme ice thickness expected at the site of interest, an annual global sea ice load can be derived deterministically. Although the simplicity of the proposed relation provides quick design load estimates, it lacks accuracy because the only dependencies are structure width, ice thickness and provided coefficients; no consideration is given to site-specific sea ice conditions and the corresponding exposure. Additionally, no term is provided for including ice management in the design load basis. This paper presents a probabilistic methodology to modify the deterministic ISO 19906 relations for determining global and local first-year sea ice loads on vertical structures. The presented methodology is based on the same ice pressure data as presented in ISO 19906, but accounts better for the influence of ice exposure, ice management and site-specific sea ice data. This is especially beneficial for ice load analyses of seasonal operations where exposure to sea ice is limited, and only thinner ice is encountered. Sea ice chart data can provide site-specific model inputs such as ice thickness estimates and partial concentrations, from which corresponding global load exceedance curves are generated. Example scenarios show dependencies of design loads on season length, structural geometry and sea ice conditions. Example results are also provided, showing dependency of design loads on the number of operation days after freeze-up, providing useful information for extending the drilling season of MODUs after freeze-up occurs.

Binding mechanisms of therapeutic antibodies to human CD20

Science ◽  
2020 ◽  
Vol 369 (6505) ◽  
pp. 793-799 ◽  
Author(s):  
Anand Kumar ◽  
Cyril Planchais ◽  
Rémi Fronzes ◽  
Hugo Mouquet ◽  
Nicolas Reyes
Keyword(s):  
B Cell ◽  
Rational Design ◽  
Local Concentration ◽  
Type I ◽  
Type Ii ◽  
Cell Binding ◽  
Complement Components ◽  
Cytotoxic Effects ◽  
Terminal Complexes ◽  
Cluster Of Differentiation

Monoclonal antibodies (mAbs) targeting human antigen CD20 (cluster of differentiation 20) constitute important immunotherapies for the treatment of B cell malignancies and autoimmune diseases. Type I and II therapeutic mAbs differ in B cell binding properties and cytotoxic effects, reflecting differential interaction mechanisms with CD20. Here we present 3.7- to 4.7-angstrom cryo–electron microscopy structures of full-length CD20 in complexes with prototypical type I rituximab and ofatumumab and type II obinutuzumab. The structures and binding thermodynamics demonstrate that upon binding to CD20, type II mAbs form terminal complexes that preclude recruitment of additional mAbs and complement components, whereas type I complexes act as molecular seeds to increase mAb local concentration for efficient complement activation. Among type I mAbs, ofatumumab complexes display optimal geometry for complement recruitment. The uncovered mechanisms should aid rational design of next-generation immunotherapies targeting CD20.

Review of Ice Load Standards and Comparison With Measurements

2017 ◽  
Author(s):  
Leon Kellner ◽  
Hauke Herrnring ◽  
Michael Ring
Keyword(s):  
Sea Ice ◽  
Offshore Structures ◽  
Classification Rules ◽  
Empirical Formulas ◽  
Ice Load ◽  
Ice Coverage ◽  
Ice Loads ◽  
Full Scale Tests ◽  
The Given

Sea ice can interact with offshore structures in regions with at least seasonal ice coverage. Therefore the prediction of ice loads on offshore structures is required by many standards or classification rules and guidelines. In order to do this, empirical formulas are often prescribed. These are based on assumptions in combination with model or full scale tests. Yet there are very few publications where the results of the formulas are actually compared to measurements. A case study is made for ice loads on the Norströmsgrund lighthouse. First of all current empirical formulas given by standards bodies or classification societies are reviewed with focus on applicability. Secondly, the ice loads predicted by the empirical formulas are compared to measurements. It was found that for the given case most methods significantly overestimate the load. The applicability of some methods is disputable.

Ice Loading Decrease at Life Cycle Main Stages for Fixed Offshore Structures

2015 ◽  
Author(s):  
Valery M. Shaposhnikov ◽  
Anatolii V. Aleksandrov ◽  
Oleg E. Litonov ◽  
Viktor V. Platonov
Keyword(s):  
Experimental Studies ◽  
Offshore Structures ◽  
Research Centre ◽  
Ice Load ◽  
Ice Drift ◽  
Load Monitoring ◽  
Design Values ◽  
Ice Loads ◽  
Ice Resistance ◽  
Positive Effect

At the present time design values of ice loads on fixed offshore structures are rather conservative. Conservatism of design ice loads consists in assuming the most unfavorable ice action direction and the worst ice drift speed; the most unfavorable combination of the consolidated layer thickness, ridge keel depth and ice strength; as well as supposing the ice ultimate strength value constant along the whole ice–structure contact area perimeter. With accumulation of the knowledge on ice formation failure under interaction with ice-resistant fixed platforms, the requirements contained in Rules of classification societies are reduced. For example, for the last forty years the lowering of requirements to design ice load values was equal to about four times [1]. For the last time specialists of Krylov State Research Centre have performed design and experimental studies where further tendency to decreasing design values of ice loads is traced. Ice monitoring is one of the main elements for justification of design ice load values’ decrease. Modern monitoring systems permit to warn about occurrence of a state close to a limit one, as well as to record actual ice loads. Ice load monitoring is a necessary part of accident prevention during ice-resistant structures operation. Monitoring of ice loads is a necessary part for providing safe operation of ice-resistance structures, and systematic accumulation of monitoring data for several years gives a positive effect in the form of justified decrease of static and dynamic design ice loads.

Influence of Structural Compliance and Slope Angle on Ice Loads and Dynamic Response of Conical Structures

2015 ◽  
Author(s):  
Gesa Ziemer ◽  
Karl-Ulrich Evers ◽  
Christian Voosen
Keyword(s):  
Natural Frequency ◽  
Model Test ◽  
Slope Angle ◽  
Offshore Structures ◽  
Model Tests ◽  
Offshore Wind Turbine ◽  
Worst Case ◽  
Ice Load ◽  
Ice Loads ◽  
Conical Structures

Model tests in ice have been conducted at the Large Ice Basin of HSVA with cylindrical and conical, compliant structures exposed to drifting level ice to investigate the influence of slope and compliance on the ice load and its breaking frequency. Main goal of the test campaign was to study the importance of structural feedback during ice-cone interaction. This is a major issue e.g. for numerical simulation of offshore structures during design phase. Four shapes were tested: 50°, 60°, 80° and 90° slope angle. The cylinder was tested in order to define the worst case scenario regarding magnitude of ice load and severity of ice-induced vibrations. Stiffness and natural frequency of the structure were chosen similar to typical values for offshore wind turbine support structures. All shapes were tested both in a compliant and fixed configuration. The breaking frequency was found to be more pronounced for the lower slope angles where the ice failed in flexural failure only, while a transition to crushing failure as observed on a cylindrical structure takes place at 80° cone angle already. This results in significantly higher ice loads on the 80° cone than on those with lower angles, but a reduced risk of severe ice-structure interaction due to the unsteady nature of the mixed mode breaking process. Although the breaking frequency is rather constant e.g. during ice impact on the 60° cone, it was not possible during the model tests to match the ice drift speed and the dynamics of the structure in a way that causes resonance. However, model test results prove that there is a risk of conical structures with low natural frequencies and low stiffness in ice plane being excited by periodic ice failure in their natural frequency, thus response amplification may take place and pose a risk to the structural integrity of conical offshore structures exposed to sea ice. This paper presents the model test setup, analysis of the results, and general findings.

A Comparison of Ice Loads From Level Ice and Ice Ridges on Sloping Offshore Structures Calculated in Accordance With Different International and National Standards

2006 ◽  
Author(s):  
Per Kristian Bruun ◽  
Ove Tobias Gudmestad
Keyword(s):  
Barents Sea ◽  
Slope Angle ◽  
Offshore Structures ◽  
Interaction Process ◽  
International Standards ◽  
Structure Interaction ◽  
Ice Load ◽  
Ice Loads ◽  
Level Ice

Existing national and international standards for determination of level ice and ice ridge loads on sloping offshore structures recommend different methods for the analysis. The objective of this paper is to review the codes and standards recommendations regarding ice-sloping structures interaction process and highlight the differences between them. Development of offshore hydrocarbon fields in the Eastern Barents Sea is foreseen to take place in the near future while developments already take place in the Pechora Sea and offshore Sakhalin as well as in the Northern Caspian Sea. One of the most difficult issues facing the designer of offshore structures for these areas is how to design for loads from level ice and ice ridges. The ice load considerations will have a major effect on the form and cost of these structures. It is known that different designers use very different ice load estimates (Shkhinek et al., 1994). The standards recommend different methods for determination of the global ice loads on both cone-shaped and sloping rectangular structures. For determination of the global ice loads on these types of structures, it is obvious that the ice-structure interaction process must be identified. Rubble effects must be included in the analysis. The ice-structure interaction process for these geometries depends on many factors, such as; the ice thickness, ice strength, ice-structure friction coefficient, ice velocity, width of the structure and slope angle of the structure. The methods for determination of ice loads recommended by the different standards are very much influenced by local ice conditions and the parameters listed above are given different importance in the different standards. The differences in loads calculated by using the different standards and their validity for the ice-structure interaction process have been investigated and example calculations are presented to show these differences. It is thought that the paper may be of interest for those preparing the new ISO standard (ISO 19906) on Arctic Offshore Structures.

Heat-Etching with a Bullivant Type II Simple Freeze-Cleave Device

1970 ◽  
Vol 28 ◽  
pp. 106-107 ◽  
Author(s):  
Ronald S. Weinstein ◽  
N. Scott McNutt
Keyword(s):  
New Zealand ◽  
General Hospital ◽  
Massachusetts General Hospital ◽  
Type I ◽  
Type Ii ◽  
Collaborative Effort ◽  
Temperature And Pressure ◽  
The University

The Type I simple cold block device was described by Bullivant and Ames in 1966 and represented the product of the first successful effort to simplify the equipment required to do sophisticated freeze-cleave techniques. Bullivant, Weinstein and Someda described the Type II device which is a modification of the Type I device and was developed as a collaborative effort at the Massachusetts General Hospital and the University of Auckland, New Zealand. The modifications reduced specimen contamination and provided controlled specimen warming for heat-etching of fracture faces. We have now tested the Mass. General Hospital version of the Type II device (called the “Type II-MGH device”) on a wide variety of biological specimens and have established temperature and pressure curves for routine heat-etching with the device.

Labelling of non-A, non-B hepatitis infected chimpanzee hepatocytes with nuclease-gold conjugates

1984 ◽  
Vol 42 ◽  
pp. 250-251
Author(s):  
G. D. Gagne ◽  
M. F. Miller ◽  
D. A. Peterson
Keyword(s):  
Endoplasmic Reticulum ◽  
Experimental Infection ◽  
Uranyl Acetate ◽  
Type I ◽  
Cellular Injury ◽  
Type Ii ◽  
Tubular Structures ◽  
Type Iii ◽  
Type Iv ◽  
Infected Chimpanzee

Experimental infection of chimpanzees with non-A, non-B hepatitis (NANB) or with delta agent hepatitis results in the appearance of characteristic cytoplasmic alterations in the hepatocytes. These alterations include spongelike inclusions (Type I), attached convoluted membranes (Type II), tubular structures (Type III), and microtubular aggregates (Type IV) (Fig. 1). Type I, II and III structures are, by association, believed to be derived from endoplasmic reticulum and may be morphogenetically related. Type IV structures are generally observed free in the cytoplasm but sometimes in the vicinity of type III structures. It is not known whether these structures are somehow involved in the replication and/or assembly of the putative NANB virus or whether they are simply nonspecific responses to cellular injury. When treated with uranyl acetate, type I, II and III structures stain intensely as if they might contain nucleic acids. If these structures do correspond to intermediates in the replication of a virus, one might expect them to contain DNA or RNA and the present study was undertaken to explore this possibility.

Comparative surface and ultrastructural views of methylotrophic bacteria by TEM, STEM, SE, and freeze-etch electron microscopy.

1987 ◽  
Vol 45 ◽  
pp. 792-793
Author(s):  
T.A. Fassel ◽  
M.J. Schaller ◽  
M.E. Lidstrom ◽  
C.C. Remsen
Keyword(s):  
Cytoplasmic Membrane ◽  
Structural Features ◽  
Methylotrophic Bacteria ◽  
Type I ◽  
Type Ii ◽  
Membrane Complex ◽  
Oxidation Of Methane ◽  
Methane Oxidizing Bacteria ◽  
Wall Structures ◽  
Methylomonas Albus

Methylotrophic bacteria play an Important role in the environment in the oxidation of methane and methanol. Extensive intracytoplasmic membranes (ICM) have been associated with the oxidation processes in methylotrophs and chemolithotrophic bacteria. Classification on the basis of ICM arrangement distinguishes 2 types of methylotrophs. Bundles or vesicular stacks of ICM located away from the cytoplasmic membrane and extending into the cytoplasm are present in Type I methylotrophs. In Type II methylotrophs, the ICM form pairs of peripheral membranes located parallel to the cytoplasmic membrane. Complex cell wall structures of tightly packed cup-shaped subunits have been described in strains of marine and freshwater phototrophic sulfur bacteria and several strains of methane oxidizing bacteria. We examined the ultrastructure of the methylotrophs with particular view of the ICM and surface structural features, between representatives of the Type I Methylomonas albus (BG8), and Type II Methylosinus trichosporium (OB-36).

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