A Review of Bone Graft Substitutes Made From HA-Polymer Composite Scaffolds and Fabrication Potential With Laser-Based Additive Manufacturing Processes

2015 ◽  
Author(s):  
Hera Wu ◽  
Shuting Lei
Keyword(s):  
Additive Manufacturing ◽  
Bone Graft ◽  
Three Dimensional ◽  
Bone Graft Substitute ◽  
Biological Properties ◽  
Porous Scaffolds ◽  
Composite Scaffolds ◽  
Bone Graft Substitutes ◽  
Manufacturing Technologies ◽  
High Level

Hydroxyapatite, a bioactive ceramic, has been combined with biodegradable polymers to create composite three-dimensional interconnected porous scaffolds for bone graft substitutes. The materials and fabrication methods of these composite scaffolds are reviewed. The resulting mechanical and biological properties of scaffolds produced from the combination of certain materials and fabrication methods are analyzed. Requirements for a bone graft substitute and third generation scaffolds with the addition of osteoinductive and osteogenic features to composite scaffolds including biomolecule delivery and cell seeding are also introduced. Finally, the benefits of using additive manufacturing technologies to enable high level of control over the design of interconnected pore structure are discussed.

Additive Manufacturing: The Next Generation of Scapholunate Ligament Reconstruction

2021 ◽  
Author(s):  
Matthew N. Rush ◽  
Christina Salas ◽  
Lorraine Mottishaw ◽  
Damian Fountain ◽  
Deana Mercer
Keyword(s):  
Additive Manufacturing ◽  
Ligament Reconstruction ◽  
Three Dimensional ◽  
Biological Properties ◽  
Bone Interface ◽  
Significant Strength ◽  
Efficient Integration ◽  
Manufacturing Methods ◽  
Manufacturing Techniques ◽  
Manufacturing Technologies

Abstract Background Ligament reconstruction, as a surgical method used to stabilize joints, requires significant strength and tissue anchoring to restore function. Historically, reconstructive materials have been fraught with problems from an inability to withstand normal physiological loads to difficulties in fabricating the complex organization structure of native tissue at the ligament-to-bone interface. In combination, these factors have prevented the successful realization of nonautograft reconstruction. Methods A review of recent improvements in additive manufacturing techniques and biomaterials highlight possible options for ligament replacement. Description of Technique In combination, three dimensional-printing and electrospinning have begun to provide for nonautograft options that can meet the physiological load and architectures of native tissues; however, a combination of manufacturing methods is needed to allow for bone-ligament enthesis. Hybrid biofabrication of bone-ligament tissue scaffolds, through the simultaneous deposition of disparate materials, offer significant advantages over fused manufacturing methods which lack efficient integration between bone and ligament materials. Results In this review, we discuss the important chemical and biological properties of ligament enthesis and describe recent advancements in additive manufacturing to meet mechanical and biological requirements for a successful bone–ligament–bone interface. Conclusions With continued advancement of additive manufacturing technologies and improved biomaterial properties, tissue engineered bone-ligament scaffolds may soon enter the clinical realm.

scholarly journals Additive Fabrication and Characterization of Biomimetic Composite Bone Scaffolds with High Hydroxyapatite Content

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 100
Author(s):  
Hoyeol Lee ◽  
Jin Myoung Yoo ◽  
Seung Yun Nam
Keyword(s):  
Bone Repair ◽  
Bone Matrix ◽  
Three Dimensional ◽  
Biological Properties ◽  
Bone Tissue Regeneration ◽  
Porous Scaffolds ◽  
Composite Scaffolds ◽  
Suitable Alternative ◽  
Native Bone ◽  
Bone Scaffolds

With the increased incidence of bone defects following trauma or diseases in recent years, three-dimensional porous scaffolds fabricated using bioprinting technologies have been widely explored as effective alternatives to conventional bone grafts, which provide cell-friendly microenvironments promoting bone repair and regeneration. However, the limited use of biomaterials poses a significant challenge to the robust and accurate fabrication of bioprinted bone scaffolds that enable effective regeneration of the target tissues. Although bioceramic/polymer composites can provide tunable biomimetic conditions, their effects on the bioprinting process are unclear. Thus, in this study, we fabricated hydroxyapatite (HA)/gelatin composite scaffolds containing large weight fractions of HA using extrusion-based bioprinting, with the aim to provide an adequate biomimetic environment for bone tissue regeneration with compositional and mechanical similarity to the natural bone matrix. The overall features of the bioprinted HA/gelatin composite scaffolds, including rheological, morphological, physicochemical, mechanical, and biological properties, were quantitatively assessed to determine the optimal conditions for both fabrication and therapeutic efficiency. The present results show that the bioprinted bioceramic/hydrogel scaffolds possess excellent shape fidelity; mechanical strength comparable to that of native bone; and enhanced bioactivity in terms of cell proliferation, attachment, and osteogenic differentiation. This study provides a suitable alternative direction for the fabrication of bioceramic/hydrogel-based scaffolds for bone repair based on bioprinting.

Magnesium substitution effect on porous scaffolds for bone repair

2011 ◽  
Vol 6 (3) ◽  
pp. 301-311 ◽  
Author(s):  
Oana Craciunescu ◽  
Christu Tardei ◽  
Lucia Moldovan ◽  
Otilia Zarnescu
Keyword(s):  
Bone Repair ◽  
Substitution Effect ◽  
Dry Weight ◽  
Collagen Type I ◽  
Biological Properties ◽  
Porous Scaffolds ◽  
Type I ◽  
Composite Scaffolds ◽  
Cross Links ◽  
Nanocomposite Scaffolds

AbstractOf great interest in developing artificial bone is the incorporation of magnesium (Mg) ions into the ceramic lattice in order to improve the physico-chemical and structural properties of the material and to increase its morphological affinity towards newly formed osseous tissue. In the present study, we evaluated the morphological and biological properties of composite scaffolds fabricated by mixing a nanopowder of Mg-substituted beta-tricalcium phosphate with collagen type I in two dry weight ratios (variant I and II). We used biochemical methods, and electron and light microscopy to investigate their porosity, biodegradability and morphology. Osteoblast cell culture behavior in the presence of nanocomposite variants was also examined. Variant I scaffold presented a higher percentage of cross-links and a better resistance to collagenase degradation compared to variant II scaffold. Their porosity did not vary significantly. Osteoblasts cultivated in the presence of nanocomposite scaffolds for 72 h exhibited good cell viability and a normal morphology. When osteoblasts were injected into the scaffolds, a slightly higher proportion of adhered cells were observed for Mg-substituted samples after 7 days of cultivation. All these results showed that Mg-containing porous composite scaffolds had controlled degradation, allowed osteoblast proliferation and adhesion and are good candidates for bone repair.

scholarly journals Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Wide Range ◽  
Potential Applications ◽  
Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

Laser Additive Manufacturing

3D Printing ◽  
2017 ◽  
pp. 154-171 ◽  
Author(s):  
Rasheedat M. Mahamood ◽  
Esther T. Akinlabi
Keyword(s):  
Additive Manufacturing ◽  
Manufacturing Process ◽  
Computer Aided Design ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Cad Model ◽  
Laser Additive Manufacturing ◽  
Computer Aided ◽  
Manufacturing Technologies ◽  
Aided Design

Laser additive manufacturing is an advanced manufacturing process for making prototypes as well as functional parts directly from the three dimensional (3D) Computer-Aided Design (CAD) model of the part and the parts are built up adding materials layer after layer, until the part is competed. Of all the additive manufacturing process, laser additive manufacturing is more favoured because of the advantages that laser offers. Laser is characterized by collimated linear beam that can be accurately controlled. This chapter brings to light, the various laser additive manufacturing technologies such as: - selective laser sintering and melting, stereolithography and laser metal deposition. Each of these laser additive manufacturing technologies are described with their merits and demerits as well as their areas of applications. Properties of some of the parts produced through these processes are also reviewed in this chapter.

scholarly journals In Vitro Evaluation of Gentamicin or Vancomycin Containing Bone Graft Substitute in the Prevention of Orthopedic Implant-Related Infections

2020 ◽  
Vol 21 (23) ◽  
pp. 9250
Author(s):  
Alessandro Bidossi ◽  
Marta Bottagisio ◽  
Nicola Logoluso ◽  
Elena De Vecchi
Keyword(s):  
Antibiotic Resistance ◽  
Bone Graft ◽  
Calcium Sulfate ◽  
Prolonged Exposure ◽  
Bacterial Colonization ◽  
Bone Graft Substitute ◽  
Bacterial Strains ◽  
Bone Graft Substitutes ◽  
Biofilm Development

Antibiotic-loaded bone graft substitutes are attractive clinical options and have been used for years either for prophylaxis or therapy for periprosthetic and fracture-related infections. Calcium sulfate and hydroxyapatite can be combined in an injectable and moldable bone graft substitute that provides dead space management with local release of high concentrations of antibiotics in a one-stage approach. With the aim to test preventive strategies against bone infections, a commercial hydroxyapatite/calcium sulfate bone graft substitute containing either gentamicin or vancomycin was tested against Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa, harboring different resistance determinants. The prevention of bacterial colonization and biofilm development by selected microorganisms was investigated along with the capability of the eluted antibiotics to select for antibiotic resistance. The addition of antibiotics drastically affected the ability of the selected strains to adhere to the tested compound. Furthermore, both the antibiotics eluted by the bone graft substitutes were able to negatively impair the biofilm maturation of all the staphylococcal strains. As expected, P. aeruginosa was significantly affected only by the gentamicin containing bone graft substitutes. Finally, the prolonged exposure to antibiotic-containing sulfate/hydroxyapatite discs did not lead to any stable or transient adaptations in either of the tested bacterial strains. No signs of the development of antibiotic resistance were found, which confirms the safety of this strategy for the prevention of infection in orthopedic surgery.

124. 3D-printed hyperelastic bone® composite scaffolds as bone graft substitutes

2019 ◽  
Vol 19 (9) ◽  
pp. S60-S61
Author(s):  
Joseph G. Lyons ◽  
Allison Greene ◽  
Jonathan T. Yamaguchi ◽  
David J. Ellenbogen ◽  
Mitchell Hallman ◽  
...  
Keyword(s):  
Bone Graft ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Bone Graft Substitutes

Madreporic coral: a new bone graft substitute for cranial surgery

1988 ◽  
Vol 69 (4) ◽  
pp. 510-513 ◽  
Author(s):  
François X. Roux ◽  
Daniel Brasnu ◽  
Bernard Loty ◽  
Bernard George ◽  
Geneviève Guillemin
Keyword(s):  
Bone Graft ◽  
Reconstructive Surgery ◽  
Experimental Studies ◽  
Bone Graft Substitute ◽  
Biological Properties ◽  
Content Type ◽  
Skull Defects ◽  
Cranial Fossa ◽  
Burr Holes ◽  
Fine Print

✓ Since 1985, the authors have been using madreporic coral fragments (genera Porites) as a bone graft substitute. Of the 167 coral grafts implanted, 150 were coral “corks” used to obliterate burr holes (diameter 10 mm), five were large implants (length 20 to 40 mm) to repair skull defects, and 12 were coral blocks to reconstruct the floor of the anterior cranial fossa. Previous experimental studies suggested that coral grafts would be well tolerated and become partially reossified as the calcific skeleton was resorbed. The authors describe their experience and detail the main biological properties of these materials, which appear to be very promising for use in cranial reconstructive surgery.

scholarly journals A 3D weaving infill pattern for fused filament fabrication

2021 ◽  
Author(s):  
Yuan Yao ◽  
Cheng Ding ◽  
Mohamed Aburaia ◽  
Maximilian Lackner ◽  
Lanlan He
Keyword(s):  
Additive Manufacturing ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Fused Filament Fabrication ◽  
Repetitive Structure ◽  
Mechanical Linkage ◽  
Manufacturing Technologies ◽  
Dimensional Object ◽  
Anisotropy Of Mechanical Properties ◽  
3D Weaving

Abstract The Fused Filament Fabrication process is the most used additive manufacturing process due to its simplicity and low operating costs. In this process, a thermoplastic filament is led through an extruder, melted, and applied to a building platform by the axial movements of an automated Cartesian system in such a way that a three-dimensional object is created layer by layer. Compared to other additive manufacturing technologies, the components produced have mechanical limitations and are often not suitable for functional applications. To reduce the anisotropy of mechanical strength in fused filament fabrication (FFF), this paper proposes a 3D weaving deposit path planning method that utilizes a 5-layer repetitive structure to achieve interlocking and embedding between neighbor slicing planes to improve the mechanical linkage within the layers. The developed algorithm extends the weaving path as an infill pattern to fill different structures and makes this process feasible on a standard three-axis 3D printer. Compared with 3D weaving printed parts by layer-to-layer deposit, the anisotropy of mechanical properties inside layers is significantly reduced to 10.21% and 0.98%.

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