Design of an Emergency Egress System for Locomotive Cabs

2003 ◽  
Author(s):  
Judith B. Gertler ◽  
James Carter ◽  
Swamidas Punwani
Keyword(s):  
Design Concepts ◽  
Emergency Rescue ◽  
Rescue Workers ◽  
The Past ◽  
Preliminary Examination ◽  
Engineering Costs ◽  
Cost Implications ◽  
The Cost ◽  
Further Development ◽  
Initial List

Improving the survivability of a locomotive crew in the event of an accident has been a concern of the Federal Railroad Administration in the past decade. Locomotive crashes can injure the crew as well as deform the locomotive cab. Exiting from a deformed cab can be difficult, particularly for injured crewmembers. Egress becomes an even greater challenge if the locomotive is toppled. From an initial list of emergency egress concepts, the following three were chosen for further development: 1) hand/footholds to aid climbing inside a toppled locomotive, 2) roof-mounted escape hatch, and 3) externally removable windshield. As the potential users of the egress system, train crews and emergency rescue workers were interviewed to provide feedback on the design concepts. Focus groups with locomotive engineers and conductors provided information about train crew perceptions of the three concepts. Interviews with rescue personnel provided a perspective on the concerns of emergency rescue operations. Based on the user feedback, the roof-mounted escape hatch with hand/footholds was selected as the preferred concept. Construction of a system mockup facilitated evaluation of this concept. The utility of the overall concept was evaluated using untrained personnel in the full-scale mockup of a toppled road locomotive cab. A preliminary examination of the cost implications of incorporating the hatch system into new locomotives indicated that the initial engineering costs, rather than the recurring manufacturing costs, are the issue. As such, the overall cost for implementing the hatch is likely to be low.

Perceived Burden of Informal Caregivers of a Chronically Ill Older Family Member

GeroPsych ◽  
2011 ◽  
Vol 24 (3) ◽  
pp. 143-154 ◽  
Author(s):  
Elmar Gräßel ◽  
Raffaela Adabbo
Keyword(s):  
Family Member ◽  
Informal Caregiver ◽  
Chronically Ill ◽  
Stress Model ◽  
The Past ◽  
Perceived Burden ◽  
Hypothetical Construct ◽  
Care Situation ◽  
The Impact ◽  
Further Development

The burden of caregivers has been intensively researched for the past 30 years and has resulted in a multitude of individual findings. This review illustrates the significance of the hypothetical construct of perceived burden for the further development and design of the homecare situation. Following explanations regarding the term informal caregiver, we derive the construct burden from its conceptual association with the transactional stress model of Lazarus and Folkman. Once the extent and characteristics of burden have been set forth, we then present the impact of perceived burden as the care situation. The question of predictors of burden will lead into the last section from which implications can be derived for homecare and relief of caregivers.

Commonwealth of Independent States: The First 20 Years

2011 ◽  
pp. 90-101 ◽  
Author(s):  
N. Shumsky
Keyword(s):  
Commonwealth Of Independent States ◽  
The Past ◽  
Independent States ◽  
Further Development

The article assesses the effectiveness and outcomes of cooperation of the Commonwealth participating states over the past 20 years. It reviews perspectives and directions for further development of the CIS taking into account the conditions and characteristics of integration processes of the post-Soviet states, implementation of the principles of multilevel and multispeed integration of the Commonwealth participating states.

Measuring the cost of environmental compliance for Waikato dairy farmers - a survey approach

2015 ◽  
Vol 77 ◽  
pp. 159-166
Author(s):  
T.O.R. Macdonald ◽  
J.S. Rowarth ◽  
F.G. Scrimgeour
Keyword(s):  
Qualitative Data ◽  
Management Practice ◽  
Dairy Farm ◽  
Environmental Compliance ◽  
Dairy Farmers ◽  
The Past ◽  
Farm Systems ◽  
The Cost ◽  
Farm System ◽  
Survey Approach

The link between dairy farm systems and cost of environmental compliance is not always clear. A survey of Waikato dairy farmers was conducted to establish the real (non-modelled) cost of compliance with environmental regulation in the region. Quantitative and qualitative data were gathered to improve understanding of compliance costs and implementation issues for a range of Waikato farm systems. The average oneoff capital cost of compliance determined through a survey approach was $1.02 per kg milksolids, $1490 per hectare and $403 per cow. Costs experienced by Waikato farmers have exceeded average economic farm surplus for the region in the past 5 years. As regulation increases there are efficiencies to be gained through implementing farm infrastructure and farm management practice to best match farm system intensity. Keywords: Dairy, compliance, farm systems, nitrogen, Waikato

Glembotskaya G.T., Eremin S.Yu. Scientific and practical approach to optimizing costs on development and promotion of drugs

2019 ◽  
Vol 2019 (3) ◽  
pp. 47-53
Author(s):  
Галина Глембоцкая ◽  
Galina Glembockaya ◽  
Станислав Еремин ◽  
Stanislav Eremin
Keyword(s):  
Scientific Literature ◽  
Pharmacological Action ◽  
Pharmaceutical Market ◽  
Pharmaceutical Companies ◽  
Strategic Development ◽  
The World ◽  
The Russian Federation ◽  
The Cost ◽  
Further Development ◽  
Registration Phase

In order to identify promising strategic development possibilities for the pharmaceutical industry in the Russian Federation, a pilot study was conducted, which has analyzed the main trends in the development of innovative medicines. As a result of the content analysis of available sources of scientific literature, the characteristics of options used in the world practice for increasing the innovative activity of individual subjects and the pharmaceutical market as a whole are presented. Possible reserves for the further development of the innovative component of the pharmaceutical market within the framework of the concept of personalized medicine according to the P4 principle (predictive - personalized - preventive - participatory) are identified and structured. The results of use by individual pharmaceutical companies of scientifically and practically justified approaches to optimizing the costs of development and promoting drugs are presented. The advantages and real prospects of a generally accepted method to reduce the cost of development by «expanding the pharmacological effect» (label expansion) of already existing drugs with a known safety profile in the world practice are shown. A scientific generalization and structuring of the goals and results of the post-registration phase of clinical trials to expand the pharmacological action of a number of drugs already existed at the market have been carried out.

Recognition Pattern, Functional Mechanism and Application of Chitin and Chitosan Oligosaccharides in Sustainable Agriculture

2020 ◽  
Vol 26 (29) ◽  
pp. 3508-3521 ◽  
Author(s):  
Xiaochen Jia ◽  
Mijanur R. Rajib ◽  
Heng Yin
Keyword(s):  
Agricultural Production ◽  
Growth And Yield ◽  
Biotic Stresses ◽  
The Past ◽  
Chitosan Oligosaccharides ◽  
Recognition Pattern ◽  
Functional Mechanism ◽  
Chitin And Chitosan ◽  
And Storage ◽  
Further Development

Background: Application of chitin attracts much attention in the past decades as the second abundant polysaccharides in the world after cellulose. Chitin oligosaccharides (CTOS) and its deacetylated derivative chitosan oligosaccharides (COS) were shown great potentiality in agriculture by enhancing plant resistance to abiotic or biotic stresses, promoting plant growth and yield, improving fruits quality and storage, etc. Those applications have already served huge economic and social benefits for many years. However, the recognition mode and functional mechanism of CTOS and COS on plants have gradually revealed just in recent years. Objective: Recognition pattern and functional mechanism of CTOS and COS in plant together with application status of COS in agricultural production will be well described in this review. By which we wish to promote further development and application of CTOS and COS–related products in the field.

Attraction of prey

2018 ◽  
Author(s):  
John D. Horner ◽  
Bartosz J. Płachno ◽  
Ulrike Bauer ◽  
Bruno Di Giusto
Keyword(s):  
Visual Cues ◽  
Synergistic Action ◽  
Carnivorous Plants ◽  
Future Research ◽  
Acoustic Cues ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
The Past ◽  
The Cost ◽  
Prey Attraction

The ability to attract prey has long been considered a universal trait of carnivorous plants. We review studies from the past 25 years that have investigated the mechanisms by which carnivorous plants attract prey to their traps. Potential attractants include nectar, visual, olfactory, and acoustic cues. Each of these has been well documented to be effective in various species, but prey attraction is not ubiquitous among carnivorous plants. Directions for future research, especially in native habitats in the field, include: the qualitative and quantitative analysis of visual cues, volatiles, and nectar; temporal changes in attractants; synergistic action of combinations of attractants; the cost of attractants; and responses to putative attractants in electroantennograms and insect behavioral tests.

scholarly journals Organic magnetoelectric and optomagnetic couplings: perspectives for organic spin optoelectronics

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Zhongxuan Wang ◽  
Wei Qin
Keyword(s):  
Ferromagnetic Materials ◽  
The Past ◽  
Potential Applications ◽  
Further Development

AbstractOver the past years, the development of organic ferromagnetic materials has been investigated worldwide for potential applications. Due to the couplings among the charge, orbit, spin, and phonon in organic ferromagnetic materials, magnetoelectric, and optomagnetic couplings have been realized and observed. In this review, progress in organic magnetoelectric and optomagnetic couplings is presented, and the mechanisms behind the phenomena are also briefly summarized. Hopefully, the understanding of magnetoelectric and optomagnetic couplings could provide guidance for the further development of organic spin optoelectronics.

scholarly journals Steroid Sulphatase and Its Inhibitors: Past, Present and Future

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2852
Author(s):  
Paul A. Foster
Keyword(s):  
Good Evidence ◽  
The Past ◽  
Steroid Sulphatase ◽  
University Of Oxford ◽  
Therapeutic Value ◽  
Breast And Prostate Cancer ◽  
The University ◽  
Further Development ◽  
Hydrolysis Of

Steroid sulphatase (STS), involved in the hydrolysis of steroid sulphates, plays an important role in the formation of both active oestrogens and androgens. Since these steroids significantly impact the proliferation of both oestrogen- and androgen-dependent cancers, many research groups over the past 30 years have designed and developed STS inhibitors. One of the main contributors to this field has been Prof. Barry Potter, previously at the University of Bath and now at the University of Oxford. Upon Prof. Potter’s imminent retirement, this review takes a look back at the work on STS inhibitors and their contribution to our understanding of sulphate biology and as potential therapeutic agents in hormone-dependent disease. A number of potent STS inhibitors have now been developed, one of which, Irosustat (STX64, 667Coumate, BN83495), remains the only one to have completed phase I/II clinical trials against numerous indications (breast, prostate, endometrial). These studies have provided new insights into the origins of androgens and oestrogens in women and men. In addition to the therapeutic role of STS inhibition in breast and prostate cancer, there is now good evidence to suggest they may also provide benefits in patients with colorectal and ovarian cancer, and in treating endometriosis. To explore the potential of STS inhibitors further, a number of second- and third-generation inhibitors have been developed, together with single molecules that possess aromatase–STS inhibitory properties. The further development of potent STS inhibitors will allow their potential therapeutic value to be explored in a variety of hormone-dependent cancers and possibly other non-oncological conditions.

Crowdsourcing the Evaluation of Design Concepts With Empathic Priming

2016 ◽  
Author(s):  
Michelle A. Pang ◽  
Carolyn C. Seepersad
Keyword(s):  
Rating Scales ◽  
Pairwise Comparison ◽  
Comparison Method ◽  
Ease Of Use ◽  
Primary Study ◽  
Design Concepts ◽  
The Impact ◽  
Further Development ◽  
Similar Evaluation ◽  
Insight Into

The evaluation of design concepts is a time consuming and resource intensive process. Crowdsourcing evaluations has been examined in previous work as a means to reduce the need for expert raters, while achieving similar evaluation results. This paper examines the impact of empathically priming novice raters on their evaluation of alternative design concepts. The rating system is based on a pairwise comparison method that requires minimal training of novice raters. In a pilot study the pairwise method for crowdsourcing evaluations is compared with crowdsourced evaluations using non-pairwise rating scales and with the evaluations of expert raters. The primary study incorporates written and empathic priming strategies to determine their impact on novice raters’ evaluation of concepts. Raters are asked to consider several criteria, including novelty, feasibility, clarity (of the concept), usefulness, ease of use, and overall worthiness of further development. Results offer insight into the criteria that are most relevant to novice raters and whether empathic priming has a significant effect on those evaluations.

Are Apprenticeships Still Relevant in the 21st Century? A Case Study of Changing Youth Training Arrangements in German Banks

ILR Review ◽  
2002 ◽  
Vol 55 (4) ◽  
pp. 667-685 ◽  
Author(s):  
David Finegold ◽  
Karin Wagner
Keyword(s):  
21St Century ◽  
Cost Savings ◽  
New Firms ◽  
Workplace Flexibility ◽  
Transferable Skills ◽  
The Past ◽  
Detailed Case ◽  
The Cost ◽  
Youth Training

The authors present a detailed case study of the evolution of apprenticeships in German banking over the past two decades to analyze why employers continue to be willing to invest in these programs that provide workers with transferable skills. They explain employers' motivation in terms of two “logics.” Some considerations stemming from the logic of consequences, such as recruitment cost savings and enhanced workplace flexibility, encourage retention of the apprenticeship system. On balance, however, the cost calculus that is at the heart of the logic of consequences would, if unopposed, encourage head-hunting for apprentices trained by other firms, eventually undermining the system. The countervailing logic of appropriateness, however, discourages defections from the system by fostering trust among employers, encouraging new firms to participate in the system, supporting the strong reputational effect associated with training, and creating mechanisms with which banks can have a hand in keeping the system efficient.

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