scholarly journals Steroid Sulphatase and Its Inhibitors: Past, Present and Future

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2852
Author(s):  
Paul A. Foster
Keyword(s):  
Good Evidence ◽  
The Past ◽  
Steroid Sulphatase ◽  
University Of Oxford ◽  
Therapeutic Value ◽  
Breast And Prostate Cancer ◽  
The University ◽  
Further Development ◽  
Hydrolysis Of

Steroid sulphatase (STS), involved in the hydrolysis of steroid sulphates, plays an important role in the formation of both active oestrogens and androgens. Since these steroids significantly impact the proliferation of both oestrogen- and androgen-dependent cancers, many research groups over the past 30 years have designed and developed STS inhibitors. One of the main contributors to this field has been Prof. Barry Potter, previously at the University of Bath and now at the University of Oxford. Upon Prof. Potter’s imminent retirement, this review takes a look back at the work on STS inhibitors and their contribution to our understanding of sulphate biology and as potential therapeutic agents in hormone-dependent disease. A number of potent STS inhibitors have now been developed, one of which, Irosustat (STX64, 667Coumate, BN83495), remains the only one to have completed phase I/II clinical trials against numerous indications (breast, prostate, endometrial). These studies have provided new insights into the origins of androgens and oestrogens in women and men. In addition to the therapeutic role of STS inhibition in breast and prostate cancer, there is now good evidence to suggest they may also provide benefits in patients with colorectal and ovarian cancer, and in treating endometriosis. To explore the potential of STS inhibitors further, a number of second- and third-generation inhibitors have been developed, together with single molecules that possess aromatase–STS inhibitory properties. The further development of potent STS inhibitors will allow their potential therapeutic value to be explored in a variety of hormone-dependent cancers and possibly other non-oncological conditions.

HISTORY, MEMORY, AND THE ENGLISH REFORMATION

2012 ◽  
Vol 55 (4) ◽  
pp. 899-938 ◽  
Author(s):  
ALEXANDRA WALSHAM
Keyword(s):  
Early Modern ◽  
Early Modern Period ◽  
English Reformation ◽  
Historical Method ◽  
The Past ◽  
University Of Cambridge ◽  
Inaugural Lecture ◽  
Modern Period ◽  
The University

ABSTRACTThis article is a revised and expanded version of my inaugural lecture as Professor of Modern History at the University of Cambridge, delivered on 20 Oct. 2011. It explores how the religious upheavals of the sixteenth and seventeenth centuries reshaped perceptions of the past, stimulated shifts in historical method, and transformed the culture of memory, before turning to the interrelated question of when and why contemporaries began to remember the English Reformation as a decisive juncture and critical turning point in history. Investigating the interaction between personal recollection and social memory, it traces the manner in which remembrance of the events of the 1530s, 1540s, and 1550s evolved and splintered between 1530 and 1700. A further theme is the role of religious and intellectual developments in the early modern period in forging prevailing models of historical periodization and teleological paradigms of interpretation.

University Startup Accelerators: Startup Launchpads or Vehicles for Entrepreneurial Learning?

2020 ◽  
pp. 251512742093175
Author(s):  
Lynn E. Metcalf ◽  
Thomas M. Katona ◽  
Jonathan L. York
Keyword(s):  
Return On Investment ◽  
Future Research ◽  
Uniform Structure ◽  
Primary Role ◽  
Entrepreneurial Ecosystem ◽  
The Past ◽  
Mode Of Operation ◽  
The University ◽  
Insight Into

Over the past decade, universities have invested heavily in startup accelerator programs; however, their role in the university entrepreneurial ecosystem is ambiguous. Are university startup accelerators intended to educate or are they created to facilitate business starts and to contribute to regional economic development? In contrast, most private-sector startup accelerators serve a consistent and differentiated role in the entrepreneurial ecosystem—they provide programming and resources to startups to increase the probability of a return on investment. Understanding the role of university startup accelerators is an important precursor to evaluating their impact and whether or not the return is worth the considerable investment. In this study, we poll university accelerator directors to gain their perspective on the role(s) that university startup accelerators play and to identify how they are structured and operated. Our research reveals a fairly uniform structure and mode of operation. While facilitating business starts is a key role for some, it confirms education as the primary role for university startup accelerators. We outline appropriate means of assessing the learning that takes place in accelerator programs, offer insight into how these findings can help accelerator directors deliver on outcomes and demonstrate impact, and propose avenues for future research.

Role of the Sarcoplasmic Reticulum Ca2+-ATPase on Heat Production and Thermogenesis

2001 ◽  
Vol 21 (2) ◽  
pp. 113-137 ◽  
Author(s):  
Leopoldo de Meis
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Atp Hydrolysis ◽  
Surrounding Medium ◽  
Chemical Energy ◽  
The Past ◽  
Sarcoplasmic Reticulum Membrane ◽  
Membrane Bound ◽  
Hydrolysis Of ◽  
Heat Released

The sarcoplasmic reticulum of skeletal muscle retains a membrane bound Ca2+-ATPase which is able to interconvert different forms of energy. A part of the chemical energy released during ATP hydrolysis is converted into heat and in the bibliography it is assumed that the amount of heat produced during the hydrolysis of an ATP molecule is always the same, as if the energy released during ATP cleavage were divided in two non-interchangeable parts: one would be converted into heat, and the other used for Ca2+ transport. Data obtained in our laboratory during the past three years indicate that the amount of heat released during the hydrolysis of ATP may vary between 7 and 32 kcal/mol depending on whether or not a transmembrane Ca2+ gradient is formed across the sarcoplasmic reticulum membrane. Drugs such as heparin and dimethyl sulfoxide are able to modify the fraction of the chemical energy released during ATP hydrolysis which is used for Ca2+ transport and the fraction which is dissipated in the surrounding medium as heat.

Struggling with the Past: Women's Theatre in Search of a History

1989 ◽  
Vol 5 (18) ◽  
pp. 107-112 ◽  
Author(s):  
Susan Bassnett
Keyword(s):  
Cultural Change ◽  
Historical Context ◽  
Feminist Criticism ◽  
Elizabeth I ◽  
The Past ◽  
Feminist Study ◽  
Introductory Article ◽  
Theatre Studies ◽  
The University

Theatre scholarship is only just beginning to respond to the insights and emphases suggested by feminist criticism. In this introductory article to what we intend to be a strong and continuing thread in NTQ, Susan Bassnett outlines the resulting problems, and explores the historical context and conditions in terms of one central issue – the role of women as performers (and non-performers) in the sixteenth and seventeenth centuries. She also examines some of the wider implications for theatre studies, affected as these also are by new historicist approaches to the study of cultural change. Susan Bassnett teaches in the Graduate School of Comparative Literary Theory in the University of Warwick, and has been a regular contributor to New Theatre Quarterly and other journals, notably in the field of Italian theatre. Her most recent books include a feminist study of Elizabeth I, and (in collaboration with John Stokes and Michael Booth) Bernhardt. Terry, Duse: the Actress in Her Time.

scholarly journals Reception as a Unity of Cultural and Historical Memory, Oblivion, and Imagination

2021 ◽  
Vol 163 (4–5) ◽  
pp. 255-265
Author(s):  
N.A. Tereshchenko ◽  
◽  
T.M. Shatunova ◽  
Keyword(s):  
Historical Memory ◽  
Modern Society ◽  
Research Interest ◽  
Modern Culture ◽  
The Past ◽  
The University ◽  
Historical Past ◽  
Further Development ◽  
Outstanding Representative

This article is dedicated to the memory of Evgenii Aleksandrovich Chiglintsev, a brilliant historian, an outstanding representative of the university intelligentsia, and a wonderful comrade with the best human qualities. E.A. Chiglintsev’s works are interdisciplinary, useful for practically all humanities, and certainly important from the philosophical and socio-philosophical perspectives. The study aims to analyze and evaluate the phenomenon of cultural reception in the context of E.A. Chiglintsev’s writings. The main problematic field of the article is the meanings, boundaries, and prospects of the phenomenon of reception, which has become one of the main subjects of E.A. Chiglintsev’s research interest. E.A. Chiglintsev focused mostly on the universal meaning of reception, whereas this article also considers its historical backgrounds, as well as the possibilities and meanings of cultural and historical receptions in the modern culture and society. The research is relevant due to the practical need to develop an adequate attitude to the past in the modern society, i.e., because of the need to distinguish what and in what forms should be remembered, what and how to forget, how to take fire from the past, not ashes. Today, every person who considers himself or herself modern must constantly undergo the path of rethinking his or her historical past, and thus participate in the reception of past cultures. The conclusion is made about the historicity of reception, the classical forms of which are developing in the modern culture, about the problematic nature of this phenomenon in the postmodern culture. The problem of further development of the meaning of reception in the modern culture and its limits is posed.

History Writing and Agency in the Scottish Highlands: Postcolonial Thought, the Work of James Macpherson (1736–1796) and Researching the Region's Past with Local Communities

2020 ◽  
Vol 11 (2) ◽  
pp. 123-138
Author(s):  
Jim MacPherson
Keyword(s):  
Local Communities ◽  
The Body ◽  
Frantz Fanon ◽  
History Writing ◽  
Alternative Futures ◽  
Scottish Highlands ◽  
The Past ◽  
James Macpherson ◽  
The University

This article argues that postcolonial thought can be used as a tool for thinking about the present in the Scottish Highlands. Taking a case study of collaborative inquiry between local communities, High Life Highland (the body responsible for cultural services in the region) and the University of the Highlands and Islands into the work and legacies of the poet and historian James Macpherson (1736–1796), it examines the way in which the approach and ideas of postcolonialism can be used to better understand the past and critically engage communities in exploring their history. Building upon the work of James Hunter and his pioneering interpretation of Highland history through the work of Frantz Fanon and Edward Said, this article considers how postcolonialism can have intellectual solidarity with histories of the region, especially when we consider the role of the Highlands in processes of colonisation and imperialism. Through this comparative analysis, it demonstrates that using the past as a resource in the present enables communities to change the ways in which their history is presented and to imagine alternative futures.

A modified incision for the trans-septal trans-sphenoidal approach to the pituitary

1989 ◽  
Vol 103 (7) ◽  
pp. 670-671
Author(s):  
Mohamed El-Fatih Baraka
Keyword(s):  
Saudi Arabia ◽  
Skull Base ◽  
Sella Turcica ◽  
Good Alternative ◽  
The Past ◽  
In Trans ◽  
The University

AbstractThe role of the otorhinolaryngologist in trans-septal trans-sphenoidal approach to hypophysectomy when undertaken conjointly with the neurosurgeon is to provide excellent and rapid exposure for the necessary neurosurgical manipulation.For the past two years at the King Fahd Hospital of the University in Al-Khobar, Saudi Arabia, a modified incision for the trans-septal trans-sphenoidal approach to the skull base around the area of the sella turcica has been undertaken in eight cases. This incision may offer a good alternative to the standard hemi-transfixation incision.

Newman's Aesthetic Vision

2011 ◽  
Vol 23 (1) ◽  
pp. 41-57
Author(s):  
Robert C. Christie ◽  
Keyword(s):  
Philosophy Of Mind ◽  
Applied Research ◽  
University Education ◽  
Past Century ◽  
John Henry Newman ◽  
The Past ◽  
Education Today ◽  
Unity Of Knowledge ◽  
The University

The evolution of scientism, relativism, and the resultant fragmentation of knowledge over the past century have led to a crisis in contemporary university education. John Henry Newman, a nineteenth-century philosopher of education, a major figure in educational theory and applied research, and author of the classic work on education, The Idea of a Univershy, faced similar problems in his time, and his work is valuable in addressing contemporary dilemmas. Newman's philosophy of mind and his vision of the unity of knowledge, which reflects an aesthetic dimension, and the resultant essential role of theology in education, are key elements for reimagining the university. An analysis of Newman's spirited Eighth Discourse anchors this retrospective and commends his work to higher education today by recalling an eariier ideal of the integration of all disciplines.

Sign in / Sign up

Export Citation Format

Share Document