Opportunities and Challenges in Micropump Technology

2002 ◽  
Author(s):  
J. Darabi ◽  
H. Wang
Keyword(s):  
Drug Delivery ◽  
Chemical Analysis ◽  
Drug Delivery Systems ◽  
State Of The Art ◽  
Cost Effective ◽  
Cooling Systems ◽  
Systems Biotechnology ◽  
Potential Applicability ◽  
Working Principle ◽  
Application Specific

The rapidly growing applications in micro fluidic systems, biotechnology, micro chemical analysis systems, drug delivery systems, and chip-integrated cooling systems has introduced new opportunities and challenges in developing micropumps. Micropumps are one of the crucial components for moving liquids in these miniaturized systems. In this article, the focus is placed on both fundamental scientific and application specific issues. First, a brief review of the growing need for micropumps and the state of the art materials and fabrication technologies is presented. Next, the various pumping techniques, their working principle and their potential applicability to the future development of cost-effective miniature systems are discussed. Finally, selected results of an electrohydrodynamic micropump are presented.

Chitosan Nanoparticles: An Approbative System for the Delivery of Herbal Bioactives

2020 ◽  
Vol 10 ◽  
Author(s):  
Sapna Saini ◽  
Sanju Nanda ◽  
Anju Dhiman
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
State Of The Art ◽  
Chitosan Nanoparticles ◽  
Delivery Systems ◽  
Intrinsic Properties ◽  
Amino Groups ◽  
Suitable Candidate ◽  
Film Forming ◽  
Novel Drug

: Chitosan, a natural biodegradable polymer obtained from deacetylation of chitin, has been used as an approbative macromolecule for the development of various novel drug delivery systems. It is one of the most favorable biodegradable carriers for nanoparticulate drug delivery due to its intrinsic properties, such as biocompatibility, biodegradability, non-toxicity, availability of free reactive amino groups, and ease of chemical modification into different active derivatives. Furthermore, interesting physical properties (film-forming, gelling and thickening) make it a suitable candidate for formulations, such as films, microcapsules, beads, nanoparticles, nanofibres, nanogel and so on. Researchers have reported that chitosan nanoparticles act as a promising vehicle for herbal actives as they provide a superior alternative to traditional carriers and improve pharmaceutical efficiency. As no review of chitosan nanoparticles encapsulating herbal extracts and bioactives has been published till date, a maiden effort has been made to collate and review the use of chitosan nanoparticles for the entrapment of phytoconstituents to yield stable, efficient and safe drug delivery systems. Additionally, the paper presents a comprehensive account of the state-of the-art in fabricating herbal chitosan nanoparticles and their current pharmacological status. A list of patents on chitosan nanoparticles of herbal actives has also been included. This review is intended to serve as a didactic discourse for the formulation scientists endeavoring to develop advanced delivery systems for herbal actives.

scholarly journals A Systematic Review on Drug Delivery Systems Based on Their Mechanism of Drug Release and Their Applications

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Amit Prakash ◽  
Amit Prakash
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Cost Effective ◽  
Delivery Systems ◽  
Oral Drug ◽  
Effective Delivery ◽  
Route Of Delivery

Oral drug delivery is the most commonly used and preferred route of delivery of pharmaceuticals which has been successfully treating wide number of diseases. The advantages of this method of delivery are patient friendly, cost effective, established delivery system, noninvasiveness and convenient, and In the pharmaceutical field it is the most favored drug delivery system. Oral drug delivery systems along with other effective delivery system types that are effective and promising are discussed in this paper based on the mechanism of drug release.

scholarly journals Drug-encapsulated carbon (DECON): A novel platform for enhanced drug delivery

2019 ◽  
Vol 5 (8) ◽  
pp. eaax0780 ◽  
Author(s):  
Tejabhiram Yadavalli ◽  
Joshua Ames ◽  
Alex Agelidis ◽  
Rahul Suryawanshi ◽  
Dinesh Jaishankar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Antiviral Drug ◽  
Cost Effective ◽  
Delivery Systems ◽  
Carbon Particles ◽  
Drug Conjugates ◽  
Carbon Structures ◽  
Simplex Virus

Current drug-delivery systems are designed primarily for parenteral applications and are either lipid or polymer drug conjugates. In our quest to inhibit herpes simplex virus infection via the compounds found in commonly used cosmetic products, we found that activated carbon particles inhibit infection and, in addition, substantially improve topical delivery and, hence, the efficacy of a common antiviral drug, acyclovir (ACV). Our in vitro studies demonstrate that highly porous carbon structures trapped virions, blocked infection and substantially improved efficacy when ACV was loaded onto them. Also, using murine models of corneal and genital herpes infections, we show that the topical use of drug-encapsulated carbon (DECON) reduced dosing frequency, shortened treatment duration, and exhibited higher therapeutic efficacy than currently approved topical or systemic antivirals alone. DECON is a nontoxic, cost-effective and nonimmunogenic alternative to current topical drug-delivery systems that is uniquely triggered for drug release by virus trapping.

Echogenic bubbles: An new avenue for cancer therapy

2021 ◽  
pp. 6-18
Author(s):  
Rajeswari Saripilli1 ◽  
Pikkala Shirisha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Cost Effective ◽  
Disease Diagnosis ◽  
Systemic Circulation ◽  
Therapeutic Agents ◽  
Site Specific ◽  
Non Invasive ◽  
Ultrasound Molecular Imaging ◽  
Novel Drug

The development of micro and nanobubbles as theranostics is been an emerging trend in the 21st century. Ultrasound molecular imaging is a real-time non-invasive, cost-effective, promising non-viral tool, which is been widely used in the recent times. These micro and nanobubbles are marked as ultrasound agents for both diagnosis and targeting therapeutic agents. These are designed in order to obtain efficient drug delivery. Micro and nanobubbles are very much used for targeting drug and achieving site specific release. These are stable and have longer residence time in systemic circulation, finally shows efficient and promising drug delivery [1]. These echogenic bubbles are helpful for disease diagnosis and therapy more prominently when compared with other novel drug delivery systems. This review describes about functioning of micro and nanobubbles along with mechanism, preparation and studies which describes the works on micro and nanobubbles.

Linalool bioactive properties and potential applicability in drug delivery systems

2018 ◽  
Vol 171 ◽  
pp. 566-578 ◽  
Author(s):  
Irina Pereira ◽  
Patrícia Severino ◽  
Ana C. Santos ◽  
Amélia M. Silva ◽  
Eliana B. Souto
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Bioactive Properties ◽  
Potential Applicability

Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives

2019 ◽  
Vol 146 ◽  
pp. 248-266 ◽  
Author(s):  
Niranjan G. Kotla ◽  
Shubhasmin Rana ◽  
Gandhi Sivaraman ◽  
Omprakash Sunnapu ◽  
Praveen K. Vemula ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Intestinal Inflammation ◽  
State Of The Art ◽  
Delivery Systems ◽  
Future Perspectives
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