Damage Behavior of Trabecular Bone

2000 ◽  
Author(s):  
Oscar C. Yeh ◽  
Glen L. Niebur ◽  
Michael J. Jaasma ◽  
Tony M. Keaveny
Keyword(s):  
Mechanical Properties ◽  
Trabecular Bone ◽  
Osteoporotic Fracture ◽  
Morphological Changes ◽  
Mechanical Loads ◽  
Damage Behavior ◽  
Age Related ◽  
Bone Damage ◽  
History Of ◽  
Catastrophic Fracture

Abstract In trabecular bone, damage refers to both the physical microstructural changes which can occur in the tissue due to mechanical loads as well as to the degradations in mechanical properties which may result from such morphological changes. One hypothesis to explain age-related increases in osteoporotic fracture risk is that a history of overloads or falls can cause damage to accumulate in trabecular bone and ultimately lead to a catastrophic fracture. The purpose of this paper is to review what is known about the complex damage behavior of trabecular bone and to suggest further avenues of research.

scholarly journals Modeling the Mechanical Consequences of Age-Related Trabecular Bone Loss by XFEM Simulation

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Ruoxun Fan ◽  
He Gong ◽  
Xianbin Zhang ◽  
Jun Liu ◽  
Zhengbin Jia ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Loss ◽  
Trabecular Bone ◽  
Bone Age ◽  
The Elderly ◽  
Extended Finite Element ◽  
Age Related ◽  
Trabecular Bone Loss ◽  
Complete Failure ◽  
Fracture Processes

The elderly are more likely to suffer from fracture because of age-related trabecular bone loss. Different bone loss locations and patterns have different effects on bone mechanical properties. Extended finite element method (XFEM) can simulate fracture process and was suited to investigate the effects of bone loss on trabecular bone. Age-related bone loss is indicated by trabecular thinning and loss and may occur at low-strain locations or other random sites. Accordingly, several ideal normal and aged trabecular bone models were created based on different bone loss locations and patterns; then, fracture processes from crack initiation to complete failure of these models were observed by XFEM; finally, the effects of different locations and patterns on trabecular bone were compared. Results indicated that bone loss occurring at low-strain locations was more detrimental to trabecular bone than that occurring at other random sites; meanwhile, the decrease in bone strength caused by trabecular loss was higher than that caused by trabecular thinning, and the effects of vertical trabecular loss on mechanical properties were more severe than horizontal trabecular loss. This study provided a numerical method to simulate trabecular bone fracture and distinguished different effects of the possible occurrence of bone loss locations and patterns on trabecular bone.

Role of Hard Tissue Inelastic Properties in the Damage Behavior of Trabecular Bone

2000 ◽  
Author(s):  
Oscar C. Yeh ◽  
Tony M. Keaveny
Keyword(s):  
Trabecular Bone ◽  
Ultimate Strain ◽  
Cortical Tissue ◽  
Hard Tissue ◽  
Skeletal Fragility ◽  
Damage Behavior ◽  
Age Related ◽  
Apparent Level ◽  
Age Related Changes

Abstract Relatively little is known about the inelastic properties of trabecular hard tissue. In cortical tissue, age-related changes in mechanical properties were primarily observed in the postyield regime [1, 2]. Most notably, the ultimate strain was found to decrease by 9% per decade [1]. If similar changes in inelastic properties exist in trabecular tissue, there could be implications for the damage behavior of trabecular bone at the whole specimen “apparent” level. Understanding the role of these inelastic properties may help researchers identify which properties of trabecular tissue are vital to characterize and may improve understanding of age-related increases in skeletal fragility.

Impact of Thresholding Techniques on Micro-CT Image Based Computational Models of Trabecular Bone

2000 ◽  
Author(s):  
Mark J. Eichler ◽  
Chi Hyun Kim ◽  
Ralph Müller ◽  
X. Edward Guo
Keyword(s):  
Mechanical Properties ◽  
Trabecular Bone ◽  
Computational Models ◽  
Volume Fraction ◽  
Bone Fractures ◽  
Bone Adaptation ◽  
Bone Architecture ◽  
Micro Ct ◽  
Bone Volume Fraction ◽  
Age Related

Abstract Age-related bone fractures are mostly influenced by trabecular bone sites. Trabecular bone constantly adapts its bone volume fraction (BV/TV) and orientation, and thus its mechanical properties, to mechanical usage. Therefore, understanding the trabecular bone adaptation process and its consequences will contribute to the better understanding of the etiology of age-related fractures. Micro-computed tomography (micro-CT) is a relatively new method to quantify the complex three-dimensional (3D) trabecular bone architecture [1,2]. Finite element computational studies can be performed on these 3D microstructural images by converting each image voxel into an element [3,4,5]. Image thresholding techniques to segment bone voxels from bone marrow voxels have a major impact on the results of these models. However, the influence of different types of thresholding techniques on the mechanical properties of bone has not been examined carefully.

Contributions of Trabecular Rods of Various Orientations in Determining the Elastic Properties of Human Vertebral Trabecular Bone

2007 ◽  
Author(s):  
Xiaowei S. Liu ◽  
X. Henry Zhang ◽  
Paul Sajda ◽  
Punam K. Saha ◽  
Felix W. Wehrli ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Trabecular Bone ◽  
Elastic Properties ◽  
Volume Fraction ◽  
Three Dimensional ◽  
Micro Computed Tomography ◽  
Bone Volume Fraction ◽  
Human Trabecular Bone ◽  
Vertebral Trabecular Bone ◽  
Age Related

Osteoporosis is an age-related disease characterized by low bone mass and architectural deterioration. Other than bone volume fraction (BV/TV), microarchitecture of trabecular bone, such as trabecular type (rods or plates), connectivity, and orientation of the trabecular network is also believed to be important in governing the mechanical properties of trabecular bone. A recent study [1] showed that the microarchitecture alone affects elastic moduli of trabecular bone and, further, that trabecular plates make a far greater contribution than rods. In human vertebral trabecular bone, the roles of transverse vs. vertical rods in conferring mechanical properties of trabecular bone have been debated [2, 3]. It has been suggested that the role of transverse trabecular rod is critical in determining elastic modulus of vertebral trabecular bone. However, without explicit classifications of trabecular type, or orientation assessment at an individual trabecula level, it is not possible yet to test this hypothesis in human trabecular bone samples despite the development of three-dimensional (3D) micro computed tomography (μCT) and μCT based finite element (FE) models of human trabecular bone. With the newly developed technique of complete volumetric decomposition and individual trabecula based orientation analyses [4], now it is possible to quantitatively examine the contributions of trabecular rods of various orientations in the elastic properties of vertebral trabecular bone.

A 20-Year Perspective on the Mechanical Properties of Trabecular Bone

1993 ◽  
Vol 115 (4B) ◽  
pp. 534-542 ◽  
Author(s):  
Tony M. Keaveny ◽  
Wilson C. Hayes
Keyword(s):  
Mechanical Properties ◽  
Trabecular Bone ◽  
Heterogeneous Material ◽  
Bone Biomechanics ◽  
Future Research ◽  
Prosthesis Loosening ◽  
Anatomic Site ◽  
Age Related ◽  
Failure Properties ◽  
The Continuum

We have reviewed highlights of the research in trabecular bone biomechanics performed over the past 20 years. Results from numerous studies have shown that trabecular bone is an extremely heterogeneous material—modulus can vary 100-fold even within the same metaphysis—with varying degrees of anisotropy. Strictly speaking, descriptions of the mechanical properties of trabecular bone should therefore be accompanied by specification of factors such as anatomic site, loading direction, and age. Research efforts have also been focused on the measurement of mechanical properties for individual trabeculae, improvement of methods for mechanical testing at the continuum level, quantification of the three-dimensional architecture of trabecular bone, and formulation of equations to relate the microstructural and continuum-level mechanical properties. As analysis techniques become more sophisticated, there is now evidence that factors such as anisotropy and heterogeneity of individual trabeculae might also have a significant effect on the continuum-level properties, suggesting new directions for future research. Other areas requiring further research are the time-dependent and multiaxial failure properties at the continuum level, and the stiffness and failure properties at the lamellar level. Continued research in these areas should enhance our understanding of issues such as age-related bone fracture, prosthesis loosening, and bone remodeling.

Age-related deterioration in trabecular bone mechanical properties at material level: Nanoindentation study of the femoral neck in women by using AFM

2012 ◽  
Vol 47 (2) ◽  
pp. 154-159 ◽  
Author(s):  
Petar Milovanovic ◽  
Jelena Potocnik ◽  
Danijela Djonic ◽  
Slobodan Nikolic ◽  
Vladimir Zivkovic ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Femoral Neck ◽  
Trabecular Bone ◽  
Bone Mechanical Properties ◽  
Age Related

Oxidative Stress, Ocular Disease and Diabetes Retinopathy

2019 ◽  
Vol 24 (40) ◽  
pp. 4726-4741 ◽  
Author(s):  
Orathai Tangvarasittichai ◽  
Surapon Tangvarasittichai
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Cell Death ◽  
Protein Modification ◽  
Morphological Changes ◽  
Corneal Dystrophy ◽  
Age Related Macular Degeneration ◽  
Ocular Diseases ◽  
Retinal Light Damage ◽  
Age Related

Background: Oxidative stress is caused by free radicals or oxidant productions, including lipid peroxidation, protein modification, DNA damage and apoptosis or cell death and results in cellular degeneration and neurodegeneration from damage to macromolecules. Results: Accumulation of the DNA damage (8HOdG) products and the end products of LPO (including aldehyde, diene, triene conjugates and Schiff’s bases) were noted in the research studies. Significantly higher levels of these products in comparison with the controls were observed. Oxidative stress induced changes to ocular cells and tissues. Typical changes include ECM accumulation, cell dysfunction, cell death, advanced senescence, disarrangement or rearrangement of the cytoskeleton and released inflammatory cytokines. It is involved in ocular diseases, including keratoconus, Fuchs endothelial corneal dystrophy, and granular corneal dystrophy type 2, cataract, age-related macular degeneration, primary open-angle glaucoma, retinal light damage, and retinopathy of prematurity. These ocular diseases are the cause of irreversible blindness worldwide. Conclusions: Oxidative stress, inflammation and autophagy are implicated in biochemical and morphological changes in these ocular tissues. The development of therapy is a major target for the management care of these ocular diseases.

Assessment of age‐related morphological changes in the testes of post‐hatch light ecotype Nigerian indigenous chicken

2020 ◽  
Author(s):  
Anietie Francis Udoumoh ◽  
Udensi Maduabuchi Igwebuike ◽  
Chidozie Nwabuisi Okoye ◽  
Ugochukwu Michael Ugwu ◽  
Chike Fidelis Oguejiofor
Keyword(s):  
Morphological Changes ◽  
Indigenous Chicken ◽  
Age Related
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