Optimizing Architecture Transitions Using Decision Networks

2020 ◽  
Vol 142 (12) ◽  
Author(s):  
Afreen Siddiqi ◽  
Eric Rebentisch ◽  
Samuel Dorchuck ◽  
Yuto Imanishi ◽  
Taisetsu Tanimichi

Abstract Architecture selection for systems undergoing rapid technological and market change is challenging. It is desirable to select architectures that can provide cost-effective possibilities for future changes and avoid architecture lock-in. However, optimal architectures for prevailing conditions may not be changeable for future adaptation. This tension between objectives for system (product) development for both short-term and long-term competitiveness has been an enduring challenge for system architects. Here, we use time-expanded decision networks (TDNs) with time-varying costs and demands to systematically explore future architecture transition pathways and strategically identify useful designs. We demonstrate a new application for autonomous driving (AD) systems, a nascent technology, where the design and capabilities of constituent components (such as sensors, processors, and data communication links) are still evolving and significant market and regulatory uncertainties persist. In this case, we model technology costs with time-based factors to explicitly include future trends. The results show that as cost differences between architectures increase and demand for new functionality changes with time, the approach is able to identify potential transition points between architecture choices that optimize the net present value (NPV) of the system. For some of the specific scenarios analyzed in this study, the NPV with optimal architecture transitions is at least 10–20% larger as compared with fixed cases. Overall, this work presents a case for planning and partly constructing architecture transition roadmaps for new systems wherein dominant architectures have not emerged.

2015 ◽  
Vol 20 (4) ◽  
pp. 242-251 ◽  
Author(s):  
Éva Kállay

Abstract. The last several decades have witnessed a substantial increase in the number of individuals suffering from both diagnosable and subsyndromal mental health problems. Consequently, the development of cost-effective treatment methods, accessible to large populations suffering from different forms of mental health problems, became imperative. A very promising intervention is the method of expressive writing (EW), which may be used in both clinically diagnosable cases and subthreshold symptomatology. This method, in which people express their feelings and thoughts related to stressful situations in writing, has been found to improve participants’ long-term psychological, physiological, behavioral, and social functioning. Based on a thorough analysis and synthesis of the published literature (also including most recent meta-analyses), the present paper presents the expressive writing method, its short- and long-term, intra-and interpersonal effects, different situations and conditions in which it has been proven to be effective, the most important mechanisms implied in the process of recovery, advantages, disadvantages, and possible pitfalls of the method, as well as variants of the original technique and future research directions.


1997 ◽  
Vol 17 (03) ◽  
pp. 161-162
Author(s):  
Thomas Hyers

SummaryProblems with unfractionated heparin as an antithrombotic have led to the development of new therapeutic agents. Of these, low molecular weight heparin shows great promise and has led to out-patient therapy of DVT/PE in selected patients. Oral anticoagulants remain the choice for long-term therapy. More cost-effective ways to give oral anticoagulants are needed.


2020 ◽  
pp. 87-97
Author(s):  
Sourish Chatterjee ◽  
Biswanath Roy

In an office space, an LED-based lighting system allows you to perform the function of a data transmitter. This article discusses the cost-effective design and development of a data-enabled LED driver that can transmit data along with its receiving part. In addition, this paper clearly outlines the application of the proposed VLC system in an office environment where ambient light interference is a severe issue of concern. The result shows satisfactory lighting characteristics in general for this area in terms of average horizontal illuminance and illuminance uniformity. At the same time, to evaluate real-time and static communication performance, Arduino interfaced MATLAB Simulink model is developed, which shows good communication performance in terms of BER (10–7) even in presence of ambient light noise with 6 dB signal to interference plus noise ratio. Our designed system is also flexible to work as a standalone lighting system, whenever data communication is not required.


Author(s):  
W.J. Parker ◽  
N.M. Shadbolt ◽  
D.I. Gray

Three levels of planning can be distinguished in grassland farming: strategic, tactical and operational. The purpose of strategic planning is to achieve a sustainable long-term fit of the farm business with its physical, social and financial environment. In pastoral farming, this essentially means developing plans that maximise and best match pasture growth with animal demand, while generating sufficient income to maintain or enhance farm resources and improvements, and attain personal and financial goals. Strategic plans relate to the whole farm business and are focused on the means to achieve future needs. They should be routinely (at least annually) reviewed and monitored for effectiveness through key performance indicators (e.g., Economic Farm Surplus) that enable progress toward goals to be measured in a timely and cost-effective manner. Failure to link strategy with control is likely to result in unfulfilled plans. Keywords: management, performance


2017 ◽  
Author(s):  
Douglas LaBrecque ◽  
◽  
Russell D. Brigham ◽  
Conny Schmidt-Hattenburger ◽  
Evan Um ◽  
...  

Energies ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 2262 ◽  
Author(s):  
Hua Han ◽  
Chao Luo ◽  
Xiaochao Hou ◽  
Mei Su ◽  
Wenbin Yuan ◽  
...  

For an AC-stacked photovoltaic (PV) inverter system with N cascaded inverters, existing control methods require at least N communication links to acquire the grid synchronization signal. In this paper, a novel decentralized control is proposed. For N inverters, only one inverter nearest the point of common coupling (PCC) needs a communication link to acquire the grid voltage phase and all other N − 1 inverters use only local measured information to achieved fully decentralized local control. Specifically, one inverter with a communication link utilizes the grid voltage phase and adopts current control mode to achieve a required power factor (PF). All other inverters need only local information without communication links and adopt voltage control mode to achieve maximum power point tracking (MPPT) and self-synchronization with grid voltage. Compared with existing methods, the communication link and complexity is greatly reduced, thus improved reliability and reduced communication costs are achieved. The effectiveness of the proposed control is verified by simulation tests.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
D Panatto ◽  
P Landa ◽  
D Amicizia ◽  
P L Lai ◽  
E Lecini ◽  
...  

Abstract Background Invasive disease due to Neisseria meningitidis (Nm) is a serious public health problem even in developed countries, owing to its high lethality rate (8-15%) and the invalidating sequelae suffered by many (up to 60%) survivors. As the microorganism is transmitted via the airborne route, the only available weapon in the fight against Nm invasive disease is vaccination. Our aim was to carry out an HTA to evaluate the costs and benefits of anti-meningococcal B (MenB) vaccination with Trumenba® in adolescents in Italy, while also considering the impact of this new vaccination strategy on organizational and ethics aspects. Methods A lifetime Markov model was developed. MenB vaccination with the two-dose schedule of Trumenba® in adolescents was compared with 'non-vaccination'. Two perspectives were considered: the National Health Service (NHS) and society. Three disease phases were defined: acute, post-acute and long-term. Epidemiological, economic and health utilities data were taken from Italian and international literature. The analysis was conducted by means of Microsoft Excel 2010®. Results Our study indicated that vaccinating adolescents (11th year of life) with Trumenba® was cost-effective with an ICER = € 7,912/QALY from the NHS perspective and € 7,758/QALY from the perspective of society. Vaccinating adolescents reduces the number of cases of disease due to meningococcus B in one of the periods of highest incidence of the disease, resulting in significant economic and health savings. Conclusions This is the first study to evaluate the overall impact of free MenB vaccination in adolescents both in Italy and in the international setting. Although cases of invasive disease due to meningococcus B are few, if the overall impact of the disease is adequately considered, it becomes clear that including anti-meningococcal B vaccination into the immunization program for adolescents is strongly recommended from the health and economic standpoints. Key messages Free, large-scale MenB vaccination is key to strengthening the global fight against invasive meningococcal disease. Anti-meningococcal B vaccination in adolescents is a cost-effective health opportunity.


2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Takahiro Kinoshita ◽  
Kensuke Moriwaki ◽  
Nao Hanaki ◽  
Tetsuhisa Kitamura ◽  
Kazuma Yamakawa ◽  
...  

Abstract Background Hybrid emergency room (ER) systems, consisting of an angiography-computed tomography (CT) machine in a trauma resuscitation room, are reported to be effective for reducing death from exsanguination in trauma patients. We aimed to investigate the cost-effectiveness of a hybrid ER system in severe trauma patients without severe traumatic brain injury (TBI). Methods We conducted a cost-utility analysis comparing the hybrid ER system to the conventional ER system from the perspective of the third-party healthcare payer in Japan. A short-term decision tree and a long-term Markov model using a lifetime time horizon were constructed to estimate quality-adjusted life years (QALYs) and associated lifetime healthcare costs. Short-term mortality and healthcare costs were derived from medical records and claims data in a tertiary care hospital with a hybrid ER. Long-term mortality and utilities were extrapolated from the literature. The willingness-to-pay threshold was set at $47,619 per QALY gained and the discount rate was 2%. Deterministic and probabilistic sensitivity analyses were conducted. Results The hybrid ER system was associated with a gain of 1.03 QALYs and an increment of $33,591 lifetime costs compared to the conventional ER system, resulting in an ICER of $32,522 per QALY gained. The ICER was lower than the willingness-to-pay threshold if the odds ratio of 28-day mortality was < 0.66. Probabilistic sensitivity analysis indicated that the hybrid ER system was cost-effective with a 79.3% probability. Conclusion The present study suggested that the hybrid ER system is a likely cost-effective strategy for treating severe trauma patients without severe TBI.


Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 931
Author(s):  
Chi-Leung Chiang ◽  
Sik-Kwan Chan ◽  
Shing-Fung Lee ◽  
Horace Cheuk-Wai Choi

Background: The IMbrave 150 trial revealed that atezolizumab plus bevacizumab (atezo–bev) improves survival in patients with unresectable hepatocellular carcinoma (HCC) (1 year survival rate: 67.2% vs. 54.6%). We assessed the cost-effectiveness of atezo–bev vs. sorafenib as first-line therapy in patients with unresectable HCC from the US payer perspective. Methods: Using data from the IMbrave 150, we developed a Markov model to compare the lifetime cost and efficacy of atezo–bev as first-line systemic therapy in HCC with those of sorafenib. The main outcomes were life-years, quality-adjusted life-years (QALYs), lifetime costs, and incremental cost-effectiveness ratio (ICER). Results: Atezo–bev demonstrated a gain of 0.44 QALYs, with an additional cost of USD 79,074. The ICER of atezo–bev was USD 179,729 per QALY when compared with sorafenib. The model was most sensitive to the overall survival hazard ratio and body weight. If we assumed that all patients at the end of the IMbrave 150 trial were cured of HCC, atezo–bev was cost-effective (ICER USD 53,854 per QALY). However, if all patients followed the Surveillance, Epidemiology, and End Results data, the ICER of atezo–bev was USD 385,857 per QALY. Reducing the price of atezo–bev by 20% and 29% would satisfy the USD 150,000/QALY and 100,000/QALY willingness-to-pay threshold. Moreover, capping the duration of therapy to ≤12 months or reducing the dosage of bev to ≤10 mg/kg would render atezo–bev cost-effective. Conclusions: The long-term effectiveness of atezo–bev is a critical but uncertain determinant of its cost-effectiveness. Price reduction would favorably influence cost-effectiveness, even if long-term clinical outcomes were modest. Further studies to optimize the duration and dosage of therapy are warranted.


Energies ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4402
Author(s):  
Chun-Kai Wang ◽  
Chien-Ming Lee ◽  
Yue-Rong Hong ◽  
Kan Cheng

Energy transition has become a priority for adaptive policy and measures taken in response to climate change around the world. This is an opportunity and a challenge for the Taiwan government to establish a climate-resilient power generation mixed to ensure electricity security as well as climate change mitigation. This study adopted a sustainable development perspective and applied optimal control theory to establish a cost-effective model to evaluate a long-term (2050), climate-resilient power generation mix for Taiwan. Furthermore, this study applies the STIRPAT approach to predict the demand of electricity by 2050 for the demand side management. The results not only showed the share of various power generation mixed, but also recommended the trajectory of electricity saving by 2050.


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