Herbert R. Lissner: The Father of Impact Biomechanics

2020 ◽  
Vol 142 (3) ◽  
Author(s):  
Albert I. King ◽  
Michele J. Grimm
Keyword(s):  
Head Injury ◽  
Human Brain ◽  
Mechanical Response ◽  
Lead Author ◽  
Blunt Impact ◽  
Impact Biomechanics ◽  
Injury Mechanisms ◽  
The Many ◽  
Insight Into

Abstract Professor Herbert R. Lissner was a pioneer in impact biomechanics, having initiated research on the injury mechanisms, mechanical response, and human tolerance of the human brain to blunt impact 80 years ago—in 1939. This paper summarizes the contributions made by Professor Lissner in head injury as well as in the many areas of impact biomechanics in which he was involved. In 1977, the Bioengineering Division of ASME established the H. R. Lissner Award to recognize outstanding career achievements in the area of biomechanics. In 1987, this award was converted to a society-wide Medal, and to date it has been awarded to 44 exemplary researchers and educators. The lead author of this paper was Professor Lissner's first and only Ph.D. student, and he offers a unique insight into his research and contributions.

scholarly journals Changing landscapes: Gay men in the west and northwest of Ireland

Sexualities ◽  
2020 ◽  
pp. 136346072098169
Author(s):  
Aidan McKearney
Keyword(s):  
Gay Men ◽  
Social Rights ◽  
Irish Society ◽  
Recent Past ◽  
Same Sex ◽  
Lgbt People ◽  
The Many ◽  
Northwest Region ◽  
The Impact ◽  
Insight Into

This article focuses on the experiences of gay men in the rural west and northwest region of Ireland, during a period of transformational social and political change in Irish society. These changes have helped facilitate new forms of LGBTQI visibility, and local radicalism in the region. Same-sex weddings, establishment of rural LGBT groups and marching under an LGBT banner at St Patricks Day parades would have been unthinkable in the recent past; but they are now becoming a reality. The men report continuing challenges in their lives as gay men in the nonmetropolitan space, but the emergence of new visibility, voice and cultural acceptance of LGBT people is helping change their lived experiences. The study demonstrates the impact of local activist LGBT citizens. Through their testimonies we can gain an insight into the many, varied and interwoven factors that have interplayed to create the conditions necessary for the men to: increasingly define themselves as gay to greater numbers of people in their localities; to embrace greater visibility and eschew strategies of silence; and aspire to a host of legal, political, cultural and social rights including same-sex marriage. Organic forms of visibility and local radicalism have emerged in the region and through an analysis of their testimonies we can see how the men continue to be transformed by an ever-changing landscape.

scholarly journals Is There a Brain Microbiome?

2021 ◽  
Vol 16 ◽  
pp. 263310552110187
Author(s):  
Christopher D Link
Keyword(s):  
Animal Models ◽  
Human Brain ◽  
Neurodegenerative Diseases ◽  
Ground Truth ◽  
Healthy Human ◽  
Strong Motivation ◽  
The Many ◽  
The Brain

Numerous studies have identified microbial sequences or epitopes in pathological and non-pathological human brain samples. It has not been resolved if these observations are artifactual, or truly represent population of the brain by microbes. Given the tempting speculation that resident microbes could play a role in the many neuropsychiatric and neurodegenerative diseases that currently lack clear etiologies, there is a strong motivation to determine the “ground truth” of microbial existence in living brains. Here I argue that the evidence for the presence of microbes in diseased brains is quite strong, but a compelling demonstration of resident microbes in the healthy human brain remains to be done. Dedicated animal models studies may be required to determine if there is indeed a “brain microbiome.”

scholarly journals Pathomechanisms in the Kidneys in Selected Protozoan Parasitic Infections

2021 ◽  
Vol 22 (8) ◽  
pp. 4209
Author(s):  
Karolina Kot ◽  
Natalia Łanocha-Arendarczyk ◽  
Michał Ptak ◽  
Aleksandra Łanocha ◽  
Elżbieta Kalisińska ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Molecular Mechanisms ◽  
Kidney Injury ◽  
Therapeutic Interventions ◽  
Parasitic Infections ◽  
Injury Mechanisms ◽  
Kidney Involvement ◽  
Leishmania Spp ◽  
Apoptosis Process ◽  
Insight Into

Leishmaniasis, malaria, toxoplasmosis, and acanthamoebiasis are protozoan parasitic infections. They remain important contributors to the development of kidney disease, which is associated with increased patients’ morbidity and mortality. Kidney injury mechanisms are not fully understood in protozoan parasitic diseases, bringing major difficulties to specific therapeutic interventions. The aim of this review is to present the biochemical and molecular mechanisms in kidneys infected with Leishmania spp., Plasmodium spp., Toxoplasma gondii, and Acanthamoeba spp. We present available mechanisms of an immune response, oxidative stress, apoptosis process, hypoxia, biomarkers of renal injury in the serum or urine, and the histopathological changes of kidneys infected with the selected parasites. Pathomechanisms of Leishmania spp. and Plasmodium spp. infections have been deeply investigated, while Toxoplasma gondii and Acanthamoeba spp. infections in the kidneys are not well known yet. Deeper knowledge of kidney involvement in leishmaniasis and malaria by presenting their mechanisms provides insight into how to create novel and effective treatments. Additionally, the presented work shows gaps in the pathophysiology of renal toxoplasmosis and acanthamoebiasis, which need further research.

scholarly journals Genome-wide identification of chitinase genes in Thalassiosira pseudonana and analysis of their expression under abiotic stresses

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Haomiao Cheng ◽  
Zhanru Shao ◽  
Chang Lu ◽  
Delin Duan
Keyword(s):  
Abiotic Stresses ◽  
Chitinase Activity ◽  
Thalassiosira Pseudonana ◽  
Centric Diatom ◽  
Carbon And Nitrogen ◽  
Genome Wide ◽  
Duplication Events ◽  
The Many ◽  
Chitinase Genes ◽  
Insight Into

Abstract Background The nitrogen-containing polysaccharide chitin is the second most abundant biopolymer on earth and is found in the cell walls of diatoms, where it serves as a scaffold for biosilica deposition. Diatom chitin is an important source of carbon and nitrogen in the marine environment, but surprisingly little is known about basic chitinase metabolism in diatoms. Results Here, we identify and fully characterize 24 chitinase genes from the model centric diatom Thalassiosira pseudonana. We demonstrate that their expression is broadly upregulated under abiotic stresses, despite the fact that chitinase activity itself remains unchanged, and we discuss several explanations for this result. We also examine the potential transcriptional complexity of the intron-rich T. pseudonana chitinase genes and provide evidence for two separate tandem duplication events during their evolution. Conclusions Given the many applications of chitin and chitin derivatives in suture production, wound healing, drug delivery, and other processes, new insight into diatom chitin metabolism has both theoretical and practical value.

scholarly journals A Mini Review: Recent Advances in Surface Modification of Porous Silicon

Materials ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 2557 ◽  
Author(s):  
Seo Lee ◽  
Jae Kang ◽  
Dokyoung Kim
Keyword(s):  
Surface Modification ◽  
Porous Silicon ◽  
Wide Spectrum ◽  
Basic Research ◽  
Recent Advances ◽  
Developed Surface ◽  
The Many ◽  
Insight Into ◽  
Biomedical Fields

Porous silicon has been utilized within a wide spectrum of industries, as well as being used in basic research for engineering and biomedical fields. Recently, surface modification methods have been constantly coming under the spotlight, mostly in regard to maximizing its purpose of use. Within this review, we will introduce porous silicon, the experimentation preparatory methods, the properties of the surface of porous silicon, and both more conventional as well as newly developed surface modification methods that have assisted in attempting to overcome the many drawbacks we see in the existing methods. The main aim of this review is to highlight and give useful insight into improving the properties of porous silicon, and create a focused description of the surface modification methods.

scholarly journals En[dj]uring [ʧ]unes or ma[tj]ure [ʤ]ukes? Yod-coalescence and yod-dropping in the Eighteenth-Century English Phonology Database

2020 ◽  
Vol 24 (3) ◽  
pp. 493-526
Author(s):  
JOAN C. BEAL ◽  
RANJAN SEN ◽  
NURIA YÁÑEZ-BOUZA ◽  
CHRISTINE WALLIS
Keyword(s):  
Eighteenth Century ◽  
Oxford English Dictionary ◽  
British English ◽  
Variation Patterns ◽  
Comprehensive Survey ◽  
Social Motivations ◽  
The Many ◽  
Historical Variation ◽  
Late Modern ◽  
Insight Into

Yod-coalescence involving alveolar consonants before Late Modern English /uː/ from earlier /iu > juː/ is still variable and diffusing in Present-day English. For example, the Oxford English Dictionary (OED) gives both (/tj dj/) and (/ʧ ʤ/) British English pronunciations for tune (/tjuːn/, /tʃuːn/), mature (/mǝˈtjʊǝ/, /mǝˈʧʊǝ/), duke (/djuːk/, /dʒuːk/) and endure (/ᵻnˈdjʊə/, /ɛnˈdjʊə/, /ᵻnˈdʒʊə/, /ɛnˈdʒʊə/, /ᵻnˈdjɔː/, /ɛnˈdjɔː/, /ᵻnˈdʒɔː/, /ɛnˈdʒɔː/). Extensive variability in yod-coalescence and yod-dropping is not recent in origin, and we can already detect relevant patterns in the eighteenth century from the evidence of a range of pronouncing dictionaries. Beal (1996, 1999) notes a tendency for northern English and Scottish authors to be more conservative with regard to yod-coalescence. She concludes that we require ‘a comprehensive survey of the many pronouncing dictionaries and other works on pronunciation’ (1996: 379) to gain more insight into the historical variation patterns underlying Present-day English.This article presents some results from such a ‘comprehensive survey’: the Eighteenth-Century English Phonology Database (ECEP). Transcriptions of all relevant words located are compared across a range of eighteenth-century sources in order to determine the chronology of yod-coalescence and yod-dropping as well as internal (e.g. stress, phoneme type, presence of a following /r/) and external (e.g. prescriptive, geographical, social) motivations for these developments.

Complement Activation in the Human Brain after Traumatic Head Injury

2001 ◽  
Vol 18 (12) ◽  
pp. 1295-1311 ◽  
Author(s):  
Bo-Michael Bellander ◽  
Sim K. Singhrao ◽  
Marcus Ohlsson ◽  
Per Mattsson ◽  
Mikael Svensson
Keyword(s):  
Head Injury ◽  
Human Brain ◽  
Complement Activation ◽  
Traumatic Head Injury ◽  
Traumatic Head

scholarly journals Dislocation–grain boundary interactions: recent advances on the underlying mechanisms studied via nanoindentation testing

2021 ◽  
Author(s):  
Farhan Javaid ◽  
Habib Pouriayevali ◽  
Karsten Durst
Keyword(s):  
Grain Boundary ◽  
Mechanical Response ◽  
Displacement Curve ◽  
Ambient Conditions ◽  
Recent Advances ◽  
Slip Transfer ◽  
Depth Analysis ◽  
Dislocation Interactions ◽  
Underlying Mechanisms ◽  
Insight Into

Abstract To comprehend the mechanical behavior of a polycrystalline material, an in-depth analysis of individual grain boundary (GB) and dislocation interactions is of prime importance. In the past decade, nanoindentation emerged as a powerful tool to study the local mechanical response in the vicinity of the GB. The improved instrumentation and test protocols allow to capture various GB–dislocation interactions during the nanoindentation in the form of strain bursts on the load–displacement curve. Moreover, the interaction of the plastic zone with the GB provides important insight into the dislocation transmission effects of distinct grain boundaries. Of great importance for the analysis and interpretation of the observed effects are microstructural investigations and computational approaches. This review paper focused on recent advances in the dislocation–GB interactions and underlying mechanisms studied via nanoindentation, which includes GB pop-in phenomenon, localized grain movement under ambient conditions, and an analysis of the slip transfer mechanism using theoretical treatments and simulations. Graphical abstract

scholarly journals An earlier role for intent in children’s partner choice versus punishment

2020 ◽  
Author(s):  
Justin Martin ◽  
Kyleigh Leddy ◽  
Liane Young ◽  
Katherine McAuliffe
Keyword(s):  
Young Children ◽  
Moral Judgment ◽  
Cognitive Processes ◽  
Developmental Trajectories ◽  
Partner Choice ◽  
Moral Judgments ◽  
Equal Weight ◽  
Behavioral Differences ◽  
The Many ◽  
Insight Into

Among the many factors that influence our moral judgments, two are especially important: whether the person caused a bad outcome and whether they intended for it to happen. Notably, the weight accorded to these factors in adulthood varies by the type of judgment being made. For punishment decisions, intentions and outcomes carry relatively equal weight; for partner choice decisions (i.e., deciding whether or not to interact with someone again), intentions are weighted much more heavily. These behavioral differences in punishment and partner choice judgments may also reflect more fundamental differences in the cognitive processes supporting these decisions. Exploring how punishment and partner choice emerge in development provides important and unique insight into these processes as they emerge and mature. Here, we explore the developmental emergence of punishment and partner choice decisions in 4- to 9-year-old children. Given the importance of intentions for partner choice decisions¬–from both theoretical and empirical perspectives–we targeted the sensitivity of these two responses to others’ intentions as well as outcomes caused. Our punishment results replicate past work: young children are more focused on outcomes caused and become increasingly sensitive to intentions with age. In contrast, partner choice judgments exhibit sensitivity to intentions at an earlier age than punishment judgments, manifesting as earlier partner choice in cases of attempted violations. These results reveal distinct developmental trajectories for punishment and partner choice judgments, with implications for our understanding of the processes underlying these two responses as well as the development of moral judgment more broadly.

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