scholarly journals Internet-of-Things-Enabled Dual-Channel Iontophoretic Drug Delivery System for Elderly Patient Medication Management

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Mynampati Akshitha Reddy ◽  
Bikash Kumar Pradhan ◽  
Dilshad Qureshi ◽  
Sumit Kumar Pal ◽  
Kunal Pal
Keyword(s):  
Drug Delivery ◽  
Medication Management ◽  
Developed Countries ◽  
Mobile App ◽  
Constant Current ◽  
Software Module ◽  
Drug Delivery Device ◽  
Dual Channel ◽  
The Developed Countries

Abstract Wireless controllers have found its application in the supervision of the patients in the hospitals. It is not only a valid issue for the developing countries but also for the developed countries. For this reason, scientists are working on the advancement of medical devices that are capable of decreasing the workload of health caregivers. In this study, the development of an iontophoretic drug delivery device that could be controlled using a mobile is described. For the purpose, hardware and a software module were developed. The hardware module consisted of a two-channel voltage-controlled constant current sources that were used for driving the iontophoretic device. A mobile app was developed to control the two-channel iontophoretic device and to monitor the loose lead of the active and the passive patches. In the case of detection of the loose lead, the specific iontophoretic channel was stopped. Further, the audio-visual indicator was developed for the detection of the detachment of the patches (loose lead). The device was tested in vitro by performing the drug release study using drug-loaded emulsion gels that were formulated.

DC Bead: In Vitro Characterization of a Drug-delivery Device for Transarterial Chemoembolization

2006 ◽  
Vol 17 (2) ◽  
pp. 335-342 ◽  
Author(s):  
Andrew L. Lewis ◽  
M. Victoria Gonzalez ◽  
Andrew W. Lloyd ◽  
Brenda Hall ◽  
Yiqing Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transarterial Chemoembolization ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
In Vitro Characterization

scholarly journals Evaluation of a chloroaluminium phthalocyanine-loaded magnetic nanoemulsion as a drug delivery device to treat glioblastoma using hyperthermia and photodynamic therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 9115-9122 ◽  
Author(s):  
L. B. de Paula ◽  
F. L. Primo ◽  
M. R. Pinto ◽  
P. C. Morais ◽  
A. C. Tedesco
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cell Lines ◽  
Maghemite Nanoparticles ◽  
Delivery Device ◽  
Drug Delivery Device

The study describes the development of magnetic nanoemulsion loaded with citrate-coated maghemite nanoparticles and photosensitizer and the in vitro studies using cell lines while combining the use of hyperthermia and photodynamic therapy therapies.

In Vitro–In Vivo Evaluation of an Oral Ghost Drug Delivery Device for the Delivery of Salmon Calcitonin

2018 ◽  
Vol 107 (6) ◽  
pp. 1605-1614 ◽  
Author(s):  
Angus R. Hibbins ◽  
Mershen Govender ◽  
Sunaina Indermun ◽  
Pradeep Kumar ◽  
Lisa C. du Toit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Salmon Calcitonin ◽  
Delivery Device ◽  
In Vivo Evaluation ◽  
Drug Delivery Device

scholarly journals Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device

Coatings ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 125
Author(s):  
Ambra Vestri ◽  
Amanda K. Pearce ◽  
Robert Cavanagh ◽  
Ioanna D. Styliari ◽  
Carlos Sanders ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Water Solubility ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Biological Assays ◽  
Drug Delivery Device ◽  
Effective Activity ◽  
Vis Spectroscopy ◽  
Starch Films

Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery.

scholarly journals Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

2013 ◽  
Vol 4 (1) ◽  
pp. 14-26 ◽  
Author(s):  
Nathan Gooch ◽  
Randon Burr ◽  
Dolly Holt ◽  
Bruce Gale ◽  
Balamurali Ambati
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
In Vitro Biocompatibility

scholarly journals A 3D Printed Self-Sustainable Cell-Encapsulation Drug Delivery Device for Periocular Transplant-Based Treatment of Retinal Degenerative Diseases

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 436 ◽  
Author(s):  
Hideto Kojima ◽  
Bibek Raut ◽  
Li-Jiun Chen ◽  
Nobuhiro Nagai ◽  
Toshiaki Abe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Retinal Pigment ◽  
Cell Encapsulation ◽  
Degenerative Diseases ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
3D Printed ◽  
Retinal Degenerative Diseases

Self-sustainable release of brain-derived neurotrophic factor (BDNF) to the retina using minimally invasive cell-encapsulation devices is a promising approach to treat retinal degenerative diseases (RDD). Herein, we describe such a self-sustainable drug delivery device with human retinal pigment epithelial (ARPE-19) cells (cultured on collagen coated polystyrene (PS) sheets) enclosed inside a 3D printed semi-porous capsule. The capsule was 3D printed with two photo curable polymers: triethylene glycol dimethacrylate (TEGDM) and polyethylene glycol dimethylacrylate (PEGDM). The capsule’s semi-porous membrane (PEGDM) could serve three functions: protecting the cells from body’s immune system by limiting diffusion (5.97 ± 0.11%) of large molecules like immunoglobin G (IgG)(150 kDa); helping the cells to survive inside the capsule by allowing diffusion (43.20 ± 2.16%) of small molecules (40 kDa) like oxygen and necessary nutrients; and helping in the treatment of RDD by allowing diffusion of cell-secreted BDNF to the outside environment. In vitro results showed a continuous BDNF secretion from the device for at least 16 days, demonstrating future potential of the cell-encapsulation device for the treatment of RDD in a minimally invasive and self-sustainable way through a periocular transplant.

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