Novel Design of a Three-Dimensional Printed Umbilical Cord Clamp: A Proof of Concept Study

2019 ◽  
Vol 13 (3) ◽  
Author(s):  
Betul Mammadov ◽  
Gulsen Vural ◽  
Ersin Aytac ◽  
Emil Mammadov
Keyword(s):  
Umbilical Cord ◽  
Umbilical Vein ◽  
Human Subjects ◽  
Three Dimensional ◽  
The Novel ◽  
3D Print ◽  
Wide Range ◽  
Fluid Leak ◽  
Umbilical Cords ◽  
Novel Design

Parents frequently report complaints regarding the excessive size of the clamp that create concerns of hooking to the clothes and inducing premature separation of the dried cord. We aimed to design three-dimensional (3D) print and test a novel umbilical clamp which would be smaller, more ergonomic, and would look more appealing to the parents. After the design and 3D printing process, the clamps were tested for fluid leak on fresh umbilical cord specimens. The umbilical vein was cannulated with a 4F feeding tube which was attached to the saline infusion bag inserted in a pressure infusion cuff. The compressed cord width was measured, and the cuff was inflated to 100 mmHg and 200 mmHg. Umbilical cord specimens of 152 patients were included in the main study. The mean umbilical cord diameter (UCD) was 11.1 ± 3.5 mm (range: 4.5–23.3 mm). The compressed cord width mean value after clamping with the novel design clamp was 17.3 ± 2.3 mm compared to the 23.5 ± 3.5 mm with the conventional clamp and this difference was statistically significant (p < 0.001). All of the novel clamps safely and efficiently clamped the umbilical cords without any fluid leak. The novel design umbilical cord clamp is a safe and efficient tool being able to clamp a wide range of umbilical cords. However, a prospective randomized trial on human subjects, safety-efficacy tests by independent healthcare providers, and patient satisfaction surveys are mandatory for the further approval of our claims.

scholarly journals Human umbilical cord stem cells – the discovery, history and possible application

2020 ◽  
Vol 8 (2) ◽  
pp. 78-82
Author(s):  
Katarzyna Stefańska ◽  
Rut Bryl ◽  
Greg Hutchings ◽  
Jamil A. Shibli ◽  
Marta Dyszkiewicz-Konwińska
Keyword(s):  
Stem Cells ◽  
Umbilical Cord ◽  
Cellular Therapy ◽  
Umbilical Vein ◽  
Embryonic Stem ◽  
Experimental Medicine ◽  
Human Umbilical Cord ◽  
History Of ◽  
Umbilical Cord Stem Cells ◽  
Umbilical Cords

AbstractStem cells are now one of the most extensively studied fields in experimental medicine. Although embryonic stem cells (ESCs) have the capability to differentiate into lineages derived from all three primary germ layers, their use remains ethically controversial. Mesenchymal stromal cells’ (MSCs) utilization is not burdened with such concerns. MSCs were primarily characterized as fibroblastic cells from bone marrow stroma, with the ability to adhere to plastic and form clonogenic colonies (CFU-Fs – colony-forming unit-fibroblasts). Subsequent studies led to their isolation from various other adult or perinatal tissues, including the umbilical cord. Although in most cases MSCs are obtained from umbilical cords’ stroma (Wharton’s jelly), it has been demonstrated that both cord’s lining and endothelial layer of umbilical vein possess the cells that fulfill the minimal criteria for MSCs published in 2006 by the International Society for Cellular Therapy. Since the initial discovery, a number of pre-clinical and clinical studies were conducted with the use of MSCs derived from umbilical cords, targeting diseases such as cancer or autoimmune diseases. Moreover, their secretome may be even more beneficial, providing an opportunity to create cell-free therapies.Running title: The history of human umbilical cord stem cells

scholarly journals HDlive for Assessment of Placenta and Umbilical Cord

2014 ◽  
Vol 8 (4) ◽  
pp. 391-399
Author(s):  
Hirokazu Tanaka ◽  
Masato Mashima
Keyword(s):  
Light Source ◽  
Umbilical Cord ◽  
Depth Perception ◽  
Obstet Gynecol ◽  
Three Dimensional ◽  
Novel Technique ◽  
Shadowing Effects ◽  
Umbilical Cords

ABSTRACT We present the latest HDlive images of normal and abnormal placentas and umbilical cords. By means of HDlive, more detailed information on placental and umbilical cord abnormalities can be obtained, because this technique is a new surfacerendering mode that uses an adjustable light source to create lighting and shadowing effects, thereby increasing depth perception. HDlive provides extraordinarily realistic imaging of the placenta and umbilical cord, making it almost impossible to differentiate between fetoscopic findings and ultrasound scans. This novel technique may assist in evaluation of the placental and umbilical cord anatomy, and offer potential advantages over conventional two- and three-dimensional ultrasound. HDlive may be an important modality in future placental and umbilical cord research and in the evaluation of their abnormalities. How to cite this article Hata T, Tanaka H, Mashima M, Kanenishi K, Marumo G. HDlive for Assessment of Placenta and Umbilical Cord. Donald School J Ultrasound Obstet Gynecol 2014;8(4):391-399.

A 3-R(SRS)RP Multi-Loop Mechanism for Space Manipulation: Design, Kinematics, Singularity, and Workspace

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Chuanyang Li ◽  
Hongwei Guo ◽  
Dewei Tang ◽  
Huiyin Yan ◽  
Rongqiang Liu ◽  
...  
Keyword(s):  
Numerical Solutions ◽  
The Novel ◽  
Forward Displacement ◽  
Aerospace Applications ◽  
Wide Range ◽  
Variable Section ◽  
Varying Λ ◽  
Mapping Diagram ◽  
The Given ◽  
Novel Design

Abstract Space manipulation has great prospects in aerospace applications. In this work, a multiloop robot, namely 3-R(SRS)RP multiloop mechanism, is presented. Its design, kinematics, singularity, and workspace are studied. The novel design is mainly reflected in the robot’s structure, variable section, and novel compound hinge. Given these features, the forward-displacement undertaken with a closed-loop method leads to a complex mapping diagram. Only numerical solutions are obtained in this model due to the variable section parameter λ. This variable affects kinematic performances such as bending and folding properties. Moreover, the node differential kinematics and the Jacobian matrix are solved to analyze singular configurations of the mechanism. The workspace is then evaluated via a numerical method with varying λ. The bending and folding properties and the continuous workspace of the given robot vary while changing λ. Hence, the robot has great potentials of good performances in various applications. With this robot, a multimodule manipulator with a wide range of operations, increased mobility and rigidity, variable geometry, and adaptable shape based on mission requirements can be constructed.

A thermogelling organic-inorganic hybrid hydrogel with excellent printability, shape fidelity and cytocompatibility for 3D bioprinting

2021 ◽  
Author(s):  
Chen Hu ◽  
Taufiq Ahmad ◽  
Malik Salman Haider ◽  
Lukas Hahn ◽  
Philipp Stahlhut ◽  
...  
Keyword(s):  
Diblock Copolymer ◽  
Molecular Level ◽  
Three Dimensional ◽  
The Novel ◽  
3D Bioprinting ◽  
Hybrid Hydrogel ◽  
Decellularized Extracellular Matrix ◽  
Ionic Crosslinking ◽  
Hybrid Hydrogels ◽  
Wide Range

Abstract Alginates are the most commonly used bioink in biofabrication, but their rheological profiles makes it very challenging to perform real 3D printing. In this study, an advanced hybrid hydrogel ink was developed, a mixture of thermogelling diblock copolymer, alginate and clay i.e. Laponite XLG. The reversible thermogelling and shear thinning properties of the diblock copolymer in the ink system improves handling and 3D printability significantly. Various three-dimensional constructs, including suspended filaments, were printed successfully with high shape fidelity and excellent stackability. Subsequent ionic crosslinking of alginate fixates the printed scaffolds, while the diblock copolymer is washed out of the structure, acting as a fugitive material on the (macro)molecular level. Finally, cell-laden printing and culture over 21 days demonstrated good cytocompatibility and feasibility of the novel hybrid hydrogels for 3D bioprinting. We believe that the developed material could be interesting for a wide range of bioprinting applications including tissue engineering and drug screening, potentially enabling also other biological bioinks such as collagen, hyaluronic acid, decellularized extracellular matrix or cellulose based bioinks.

Impact of a multi-splitter vane configuration on the losses in a 1.5 turbine stage

2011 ◽  
Vol 225 (7) ◽  
pp. 964-974 ◽  
Author(s):  
T Yasa ◽  
S Lavagnoli ◽  
G Paniagua
Keyword(s):  
Three Dimensional ◽  
Low Pressure ◽  
Navier Stokes ◽  
The Novel ◽  
Turbine Stage ◽  
Performance Limitation ◽  
Numerical Research ◽  
Generation Mechanisms ◽  
Multi Body ◽  
Novel Design

This study presents the influence of a multi-body architecture on the aerodynamic performance of a low-pressure stator. The novel design has been studied numerically in a one-and-a-half stage turbine by means of a three-dimensional Reynolds-averaged Navier–Stokes simulation. This numerical research compares the behaviour of low-pressure stator composed of two different vanes against a conventional axisymmetric single airfoil row. The computational fluid dynamics predictions were calibrated using experimental aerodynamic measurements. Loss generation mechanisms were evaluated for the conventional and multi-splitter cascades at nominal and off-design conditions. At design conditions, the novel stator and conventional designs show comparable performances. However, the performance is drastically reduced at off-design conditions due to the sensitivity of the structural vanes to flow incidence. This article addresses the performance limitation for the multi-splitter vane configuration and presents a new tool to analyse the non-uniform flow conditions associated with such novel design. This procedure should help researchers in addressing any non-axisymmetric design.

Design of a Motor-Driven Mechanism to Conduct Experiments to Determine the Passive Joint Properties of the Human Index Finger

2011 ◽  
Author(s):  
Pei-Hsin Kuo ◽  
Jerod Hayes ◽  
Ashish D. Deshpande
Keyword(s):  
Index Finger ◽  
Human Subjects ◽  
Human Hand ◽  
The Novel ◽  
Prosthetic Hands ◽  
Joint Properties ◽  
Driven System ◽  
New Generation ◽  
Novel Design

Our long term goal is to develop a new generation of robotic-prosthetic hands that will incorporate key anatomical features of the human hand, especially, the passive dynamics defined by the joint stifftness and damping properties. This paper presents a design of a mechanism that can measure the passive moment of the human hand joint. We designed a motor-driven system, integrating a noninvasive and infrared motion capture system, that can control and record the angle, angular velocity and passive forces of the metacarpophalangeal (MCP) joint in the index finger. A total of 19 subjects participated in the experiments. We conducted two experiments to estimate the total passive moments of the MCP joint from the human subjects. The results showed that the novel design of the mechanism collected the precise passive moments and kinematic data, thus allowing us to develop a comprehensive understanding of the passive properties of the human hand joints.

scholarly journals Histomorphometry of Umbilical Cord and its Vessels in Pre- Eclampsia as Compared to Normal Pregnancies

2013 ◽  
Vol 7 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Manisha Barnwal ◽  
SK Rathi ◽  
S Chhabra ◽  
S Nanda
Keyword(s):  
Umbilical Cord ◽  
Wall Thickness ◽  
Morphological Changes ◽  
Umbilical Vein ◽  
Vein Wall ◽  
Group I ◽  
Formalin Fixed Paraffin ◽  
Luminal Area ◽  
Formalin Fixed Paraffin Embedded ◽  
Umbilical Cords

Aims: To study and compare the morphometric alteration in the umbilical cord obtained from thirty normal pregnancies (Group-I) and thirty pre-eclamptic pregnancies (Group-II). Methods: Morphological changes in umbilical cords were examined on formalin fixed paraffin embedded section. Various parameters were measured by planimeter. Results: In pre-eclamptic group total vessel area, total vein area, total luminal area of vein, and wall thickness of arteries were increased, whereas jelly area and wall thickness of vein were decreased as compared to normal group. Conclusion: Increased umbilical arterial thickness, decreased umbilical vein wall thickness and increased luminal area of vein which could be a predictor of intrauterine growth retardation in term pre-eclamptic patients. Nepal Journal of Obstetrics and Gynaecology / Vol 7 / No. 1 / Issue 13 / Jan- June, 2012 / 28-32 DOI: http://dx.doi.org/10.3126/njog.v7i1.8832

scholarly journals Novel Design of Additively Manufactured Micromixer in a Microchannel Comprising Mounting and Sealing Elements

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 1000 ◽  
Author(s):  
Martin Oellers ◽  
Frank Bunge ◽  
Frieder Lucklum ◽  
Sander van den Driesche ◽  
Michael J. Vellekoop
Keyword(s):  
Contact Surface ◽  
Three Dimensional ◽  
The Novel ◽  
Two Photon ◽  
Interfacial Contact ◽  
Increased Strength ◽  
Important Design ◽  
Sealing Elements ◽  
Novel Design ◽  
Two Photon Polymerization

An additively manufactured three-dimensional mixing element (3DME) integrated in a microchannel is presented. The 3DME increases the interfacial contact-surface by swapping the positions of the incoming streaming liquids. The novel design incorporates important design alterations to a prior prototype. These alterations significantly improve the integration of microelements written by two-photon polymerization (2pp) into photolithographically defined microchannels. Anchor-structures for increased strength as well as a roof to compensate for height-discrepancies between the lithographically defined microchannel and the 2pp-written 3DME are addressed. These allow for a better positioning as well as an increased sealing reliability between the top of the 3DME and a PDMS-lid which in our case is used to close the microchannel.

Preparation of Continuous Al2O3/Y2O3 Coating on Carbon Fiber by a Novel Aqueous Plasma Electrolysis

2017 ◽  
Vol 898 ◽  
pp. 1575-1582 ◽  
Author(s):  
Yu Ping Zhang ◽  
Yong Hua Shen ◽  
Wei Wei Chen ◽  
Huan Wu Cheng ◽  
Lu Wang
Keyword(s):  
Carbon Fiber ◽  
Fiber Bundle ◽  
Three Dimensional ◽  
Isothermal Oxidation ◽  
The Novel ◽  
Plasma Arc ◽  
Plasma Electrolysis ◽  
Wide Range ◽  
Carbon Fiber Reinforced Composites ◽  
Coated Carbon

A novel aqueous plasma electrolysis applied for depositing a uniform and continuous Al2O3/Y2O3 ceramic coating on each fiber within a carbon fiber bundle are reported in this study. All equally spaced tungsten wires generated plasma arc, where the plasma was overlapped, excluded and extruded each other, finally a cylindrical plasma arc zone was formed, promoting the full coverage of the coating on each fiber. The Al2O3/Y2O3 coating protected the carbon fiber from oxidation above 850oC. Similarly, the coating significantly improved the oxidation resistance of the carbon fiber with the mass loss of ~5% after isothermal oxidation in N2 atmosphere at 800°C for 30 min, compared to ~14% of bare carbon fiber. By the movement of the T300 carbon fiber bundle, 1500 m coated carbon fiber bundle with the high-quality Al2O3/Y2O3 coating deposited on each fiber was successfully realized. It is believed that the novel aqueous plasma electrolysis will find a wide range of applications in modifying the interface of the carbon fiber reinforced composites. The present investigation will also open up a new horizon for preparing a protective coating on each fiber within two/three-dimensional carbon fiber fabric.

Ultrastructure of the Omphalomesenteric Duct Rest in the Umbilical Cord at Term

1982 ◽  
Vol 40 ◽  
pp. 250-251
Author(s):  
B. A. Clark ◽  
T. Okagaki
Keyword(s):  
Umbilical Cord ◽  
Umbilical Vein ◽  
Meckel’S Diverticulum ◽  
Meckel's Diverticulum ◽  
Columnar Epithelium ◽  
Omphalomesenteric Duct ◽  
Umbilical Arteries

Vestiges of the omphalomesenteric or vitello-intestinal duct and the pathologic implications attributed to these remnants have been treated in great detail by several investigators. Persistence of the omphalomesenteric duct is associated with such conditions as Meckel's diverticulum, umbilical fistula, mucosal polyps, and sinuses or cysts of the umbilicus. Remnants of the duct in the umbilical cord, although infrequent, are located outside of the triangle formed by the two umbilical arteries and the umbilical vein, are usually discontinuous and are often represented by a small lumen lined by cuboidal or columnar epithelium. This study will examine the ultrastructure of these cells.

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