scholarly journals Comparison of Biomechanical Properties and Microstructure of Trabeculae Carneae, Papillary Muscles, and Myocardium in the Human Heart

2018 ◽  
Vol 141 (2) ◽  
Author(s):  
Fatemeh Fatemifar ◽  
Marc D. Feldman ◽  
Meagan Oglesby ◽  
Hai-Chao Han
Keyword(s):  
Human Heart ◽  
Computational Models ◽  
Strain Energy Function ◽  
Tensile Tests ◽  
Left Ventricular ◽  
Collagen Content ◽  
Uniaxial Tensile ◽  
Papillary Muscles ◽  
Microstructural Characteristics ◽  
Ventricular Compliance

Trabeculae carneae account for a significant portion of human ventricular mass, despite being considered embryologic remnants. Recent studies have found trabeculae hypertrophy and fibrosis in hypertrophied left ventricles with various pathological conditions. The objective of this study was to investigate the passive mechanical properties and microstructural characteristics of trabeculae carneae and papillary muscles compared to the myocardium in human hearts. Uniaxial tensile tests were performed on samples of trabeculae carneae and myocardium strips, while biaxial tensile tests were performed on samples of papillary muscles and myocardium sheets. The experimental data were fitted with a Fung-type strain energy function and material coefficients were determined. The secant moduli at given diastolic stress and strain levels were determined and compared among the tissues. Following the mechanical testing, histology examinations were performed to investigate the microstructural characteristics of the tissues. Our results demonstrated that the trabeculae carneae were significantly stiffer (Secant modulus SM2 = 80.06 ± 10.04 KPa) and had higher collagen content (16.10 ± 3.80%) than the myocardium (SM2 = 55.14 ± 20.49 KPa, collagen content = 10.06 ± 4.15%) in the left ventricle. The results of this study improve our understanding of the contribution of trabeculae carneae to left ventricular compliance and will be useful for building accurate computational models of the human heart.

scholarly journals Biomechanical-Structural Correlation of Chordae tendineae in Animal Models: A Pilot Study

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1678
Author(s):  
Justyn Gach ◽  
Izabela Janus ◽  
Agnieszka Mackiewicz ◽  
Tomasz Klekiel ◽  
Agnieszka Noszczyk-Nowak
Keyword(s):  
Mitral Valve ◽  
Complex Structure ◽  
Future Research ◽  
Uniaxial Tensile ◽  
Uniaxial Tensile Test ◽  
Histopathological Analysis ◽  
Papillary Muscles ◽  
Chordae Tendineae ◽  
Structural Correlation ◽  
Ring Valve

The mitral valve apparatus is a complex structure consisting of the mitral ring, valve leaflets, papillary muscles and chordae tendineae (CT). The latter are mainly responsible for the mechanical functions of the valve. Our study included investigations of the biomechanical and structural properties of CT collected from canine and porcine hearts, as there are no studies about these properties of canine CT. We performed a static uniaxial tensile test on CT samples and a histopathological analysis in order to examine their microstructure. The results were analyzed to clarify whether the changes in mechanical persistence of chordae tendineae are combined with the alterations in their structure. This study offers clinical insight for future research, allowing for an understanding of the process of chordae tendineae rupture that happens during degenerative mitral valve disease—the most common heart disease in dogs.

Replication of left ventricular haemodynamics with a simple planar mitral valve model

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Anna Daub ◽  
Jochen Kriegseis ◽  
Bettina Frohnapfel
Keyword(s):  
Mitral Valve ◽  
Computational Models ◽  
Vortex Formation ◽  
Flow Characteristics ◽  
Left Ventricular ◽  
Computational Effort ◽  
Type Model ◽  
Diastolic Phase ◽  
Valve Model ◽  
Modelling Approach

AbstractTools for the numerical prediction of haemodynamics in multi-disciplinary integrated heart simulations have to be based on computational models that can be solved with low computational effort and still provide physiological flow characteristics. In this context the mitral valve model is important since it strongly influences the flow kinematics, especially during the diastolic phase. In contrast to a 3D valve, a vastly simplified valve model in form of a simple diode is known to be unable to reproduce the characteristic vortex formation and unable to promote a proper ventricular washout. In the present study, an adaptation of the widely used simplest modelling approach for the mitral valve is employed and compared to a physiologically inspired 3D valve within the same ventricular geometry. The adapted approach shows enhanced vortex formation and an improved ventricular washout in comparison to the diode type model. It further shows a high potential in reproducing the main flow characteristics and related particle residence times generated by a 3D valve.

scholarly journals Texture Selection Mechanisms during Recrystallization and Grain Growth of a Magnesium-Erbium-Zinc Alloy

Metals ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 171
Author(s):  
Fatim-Zahra Mouhib ◽  
Fengyang Sheng ◽  
Ramandeep Mandia ◽  
Risheng Pei ◽  
Sandra Korte-Kerzel ◽  
...  
Keyword(s):  
Grain Growth ◽  
Ternary Alloy ◽  
Solute Drag ◽  
Tensile Tests ◽  
Electron Back Scatter Diffraction ◽  
Zinc Alloy ◽  
Uniaxial Tensile ◽  
Microstructural Stability ◽  
Solid Solution Strengthening ◽  
Zener Drag

Binary and ternary Mg-1%Er/Mg-1%Er-1%Zn alloys were rolled and subsequently subjected to various heat treatments to study texture selection during recrystallization and following grain growth. The results revealed favorable texture alterations in both alloys and the formation of a unique ±40° transvers direction (TD) recrystallization texture in the ternary alloy. While the binary alloy underwent a continuous alteration of its texture and grain size throughout recrystallization and grain growth, the ternary alloy showed a rapid rolling (RD) to transvers direction (TD) texture transition occurring during early stages of recrystallization. Targeted electron back scatter diffraction (EBSD) analysis of the recrystallized fraction unraveled a selective growth behavior of recrystallization nuclei with TD tilted orientations that is likely attributed to solute drag effect on the mobility of specific grain boundaries. Mg-1%Er-1%Zn additionally exhibited a stunning microstructural stability during grain growth annealing. This was attributed to a fine dispersion of dense nanosized particles in the matrix that impeded grain growth by Zener drag. The mechanical properties of both alloys were determined by uniaxial tensile tests combined with EBSD assisted slip trace analysis at 5% tensile strain to investigate non-basal slip behavior. Owing to synergic alloying effects on solid solution strengthening and slip activation, as well as precipitation hardening, the ternary Mg-1%Er-1%Zn alloy demonstrated a remarkable enhancement in the yield strength, strain hardening capability, and failure ductility, compared with the Mg-1%Er alloy.

Comprehensive study on mechanical properties of coated biaxial warp-knitted fabrics

2021 ◽  
pp. 073168442110204
Author(s):  
Bin Yang ◽  
Yingying Shang ◽  
Zeliang Yu ◽  
Minger Wu ◽  
Youji Tao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Failure Modes ◽  
Least Squares Method ◽  
Tensile Tests ◽  
Tensile Creep ◽  
Base Layer ◽  
Sustained Load ◽  
Uniaxial Tensile ◽  
Membrane Structures ◽  
Knitted Fabrics

In recent years, coated fabrics have become the major material used in membrane structures. Due to the special structure of base layer and mechanical properties, coated biaxial warp-knitted fabrics are increasingly applied in pneumatic structures. In this article, the mechanical properties of coated biaxial warp-knitted fabrics are investigated comprehensively. First, off-axial tensile tests are carried out in seven in-plane directions: 0°, 15°, 30°, 45°, 60°, 75°, and 90°. Based on the stress–strain relationship, tensile strengths are obtained and failure modes are studied. The adaptability of Tsai–Hill criterion is analyzed. Then, the uniaxial tensile creep test is performed under 24-h sustained load and the creep elongation is calculated. Besides, tearing strengths in warp and weft directions are obtained by tearing tests. Finally, the biaxial tensile tests under five different load ratios of 1:1, 2:1, 1:2, 1:0, and 0:1 are carried out, and the elastic constants and Poisson’s ratio are calculated using the least squares method based on linear orthotropic assumption. Moreover, biaxial specimens under four load ratios of 3:1, 1:3, 5:1, and 1:5 are further tensile tested to verify the adaptability of linear orthotropic model. These experimental data offer a deeper and comprehensive understanding of mechanical properties of coated biaxial warp-knitted fabrics and could be conveniently adopted in structural design.

scholarly journals A Flow Stress Model of 300M Steel for Isothermal Tension

Materials ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 252
Author(s):  
Rongchuang Chen ◽  
Shiyang Zhang ◽  
Xianlong Liu ◽  
Fei Feng
Keyword(s):  
Flow Stress ◽  
Constitutive Model ◽  
Tensile Deformation ◽  
Flow Behavior ◽  
Tensile Tests ◽  
Uniaxial Tensile ◽  
Model Parameters ◽  
Average Deviation ◽  
Cross Sectional ◽  
300M Steel

To investigate the effect of hot working parameters on the flow behavior of 300M steel under tension, hot uniaxial tensile tests were implemented under different temperatures (950 °C, 1000 °C, 1050 °C, 1100 °C, 1150 °C) and strain rates (0.01 s−1, 0.1 s−1, 1 s−1, 10 s−1). Compared with uniaxial compression, the tensile flow stress was 29.1% higher because dynamic recrystallization softening was less sufficient in the tensile stress state. The ultimate elongation of 300M steel increased with the decrease of temperature and the increase of strain rate. To eliminate the influence of sample necking on stress-strain relationship, both the stress and the strain were calibrated using the cross-sectional area of the neck zone. A constitutive model for tensile deformation was established based on the modified Arrhenius model, in which the model parameters (n, α, Q, ln(A)) were described as a function of strain. The average deviation was 6.81 MPa (6.23%), showing good accuracy of the constitutive model.

Experimental Investigation of Ti-6Al-4V with a Biaxial Tensile Test Setup at Elevated Temperature

2014 ◽  
Vol 622-623 ◽  
pp. 273-278 ◽  
Author(s):  
Marion Merklein ◽  
Sebastian Suttner ◽  
Adam Schaub
Keyword(s):  
Elevated Temperature ◽  
Elevated Temperatures ◽  
Tensile Tests ◽  
Advanced Materials ◽  
Uniaxial Tensile ◽  
Plastic Yielding ◽  
Characterization Methods ◽  
Specific Strength ◽  
Biaxial Tensile ◽  
Stress States

The requirement for products to reduce weight while maintaining strength is a major challenge to the development of new advanced materials. Especially in the field of human medicine or aviation and aeronautics new materials are needed to satisfy increasing demands. Therefore the titanium alloy Ti-6Al-4V with its high specific strength and an outstanding corrosion resistance is used for high and reliable performance in sheet metal forming processes as well as in medical applications. Due to a meaningful and accurate numerical process design and to improve the prediction accuracy of the numerical model, advanced material characterization methods are required. To expand the formability and to skillfully use the advantage of Ti-6Al-4V, forming processes are performed at elevated temperatures. Thus the investigation of plastic yielding at different stress states and at an elevated temperature of 400°C is presented in this paper. For this reason biaxial tensile tests with a cruciform shaped specimen are realized at 400°C in addition to uniaxial tensile tests. Moreover the beginning of plastic yielding is analyzed in the first quadrant of the stress space with regard to complex material modeling.

Effect of Polyvinyl Alcohol Concentration on the Mechanical Properties of Collagen/Polyvinyl Alcohol Blends

2015 ◽  
Vol 732 ◽  
pp. 161-164 ◽  
Author(s):  
Jan Vesely ◽  
Lukas Horny ◽  
Hynek Chlup ◽  
Milos Beran ◽  
Milan Krajicek ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tensile Stress ◽  
Polyvinyl Alcohol ◽  
Modulus Of Elasticity ◽  
Tensile Tests ◽  
Ultimate Tensile Stress ◽  
Alcohol Concentration ◽  
Uniaxial Tensile ◽  
Initial Modulus ◽  
Water Saturated

The effects of the polyvinyl alcohol (PVA) concentration on mechanical properties of hydrogels based on blends of native or denatured collagen / PVA were examined. Blends of PVA with collagen were obtained by mixing the solutions in different ratios, using glycerol as a plasticizer. The solutions were cast on polystyrene plates and the solvent was allowed to evaporate at room temperature. Uniaxial tensile tests were performed in order to obtain the initial modulus of elasticity (up to deformation 0.1), the ultimate tensile stress and the deformation at failure of the material in the water-saturated hydrogel form. It was found that the material was elastic and the addition of PVA helped to enhance both the ultimate tensile stress and modulus of elasticity of the films. Samples prepared from denaturated collagen showed the higher ultimate tensile stress and the deformation at failure in comparison with those prepared from native collagen. The results suggest that we could expect successful application of the collagen/PVA biomaterial for tissue engineering.

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