scholarly journals Blood Damage Quantification in Cardiovascular Flows Through Medical Devices Using a Novel Suspension Flow Method

2013 ◽  
Vol 7 (4) ◽  
Author(s):  
B. Min Yun ◽  
Cyrus K. Aidun ◽  
Ajit P. Yoganathan
Keyword(s):  
Medical Devices ◽  
Suspension Flow ◽  
Blood Damage ◽  
Flow Method ◽  
Damage Quantification

Blood Damage Quantification in Cardiovascular Flows Through Medical Devices Using a Novel Suspension Flow Method

2013 ◽  
Author(s):  
B. Min Yun ◽  
Cyrus K. Aidun ◽  
Ajit P. Yoganathan
Keyword(s):  
Mechanical Heart Valve ◽  
Alternative Methods ◽  
Suspension Flow ◽  
Spatiotemporal Resolution ◽  
Flow Solver ◽  
Jude Medical ◽  
Blood Damage ◽  
Bileaflet Mechanical Heart Valve ◽  
Damage Quantification ◽  
Baseline Case

A numerical suspension flow solver is presented that can accurately quantify blood damage in cardiovascular flows. This method is capable of high spatiotemporal resolution simulations with optimal parallel computing. In addition, the method models realistic platelets for more accurate damage quantification compared to alternative methods. The numerical tool is tested on a baseline case of a St. Jude Medical bileaflet mechanical heart valve, and blood damage results are analyzed in both Lagrangian and Eulerian viewpoints.

Asymptotically Consistent Numerical Approximation of Hemolysis

2006 ◽  
Vol 128 (5) ◽  
pp. 688-696 ◽  
Author(s):  
Marie-Isabelle Farinas ◽  
André Garon ◽  
David Lacasse ◽  
Donatien N’dri
Keyword(s):  
Shear Stress ◽  
Medical Devices ◽  
Numerical Approximation ◽  
Damage Function ◽  
Computational Domain ◽  
In Vitro Experiments ◽  
Blood Damage ◽  
Volume Integration ◽  
Consistent Approach

In a previous communication, we have proposed a numerical framework for the prediction of in vitro hemolysis indices in the preselection and optimization of medical devices. This numerical methodology is based on a novel interpretation of Giersiepen-Wurzinger blood damage correlation as a volume integration of a damage function over the computational domain. We now propose an improvement of this approach based on a hyperbolic equation of blood damage that is asymptotically consistent. Consequently, while the proposed correction has yet to be proven experimentally, it has the potential to numerically predict more realistic red blood cell destruction in the case of in vitro experiments. We also investigate the appropriate computation of the shear stress scalar of the damage fraction model. Finally, we assess the validity of this consistent approach with an analytical example and with some 3D examples.

Blood Flow Through Channels and Clearances in Implantable Pumps

2007 ◽  
Author(s):  
Steven W. Day
Keyword(s):  
Medical Devices ◽  
Blood Cells ◽  
Mechanical Design ◽  
Design Criteria ◽  
Design Strategies ◽  
Blood Damage ◽  
Blood Pumps ◽  
Patients With Heart Failure ◽  
Flow Through ◽  
Rotary Blood Pumps

Implantable rotary blood pumps are very effective at supporting patients with heart failure. New designs demonstrate distinct advantages over their predecessor diaphragm type pumps and have generated vast interest in the medical devices community, as demonstrated by hundreds of technical publications and newer commercially available devices. In addition to mechanical design criteria, these pumps share the requirement of moving a relatively large amount of blood through a miniaturized pump without damaging the blood cells. The fluid channels within the impeller are typically 1–3 mm wide and the clearance between the blades, rotating at 2,000–10,000 rpm, and the stationary housing is approximately 100–300μm. This paper gives examples of experimental and numerical methods to characterize the flow field, and a summary of how the flow affects blood cells and design strategies to minimize blood damage.

Ultrastructural changes in murine lymphoma cells exposed to ultraviolet-A radiation

1991 ◽  
Vol 49 ◽  
pp. 104-105
Author(s):  
Delma P. Thomas ◽  
Dianne E. Godar
Keyword(s):  
Medical Devices ◽  
Blood Cells ◽  
White Blood Cells ◽  
Consumer Products ◽  
Ultrastructural Changes ◽  
Ultraviolet A ◽  
Uv Spectrum ◽  
Lymphoma Cells ◽  
Murine Lymphoma ◽  
Transmission Electron

Ultraviolet radiation (UVR) from all three waveband regions of the UV spectrum, UVA (320-400 nm), UVB (290-320 nm), and UVC (200-290 nm), can be emitted by some medical devices and consumer products. Sunlamps can expose the blood to a considerable amount of UVR, particularly UVA and/or UVB. The percent transmission of each waveband through the epidermis to the dermis, which contains blood, increases in the order of increasing wavelength: UVC (10%) < UVB (20%) < UVA (30%). To investigate the effects of UVR on white blood cells, we chose transmission electron microscopy to examine the ultrastructure changes in L5178Y-R murine lymphoma cells.

Bacterial biofilm behavior in water-supply lines of dental units

1992 ◽  
Vol 50 (1) ◽  
pp. 882-883
Author(s):  
B.D. Tall ◽  
K.S. George ◽  
R. T. Gray ◽  
H.N. Williams
Keyword(s):  
Water Supply ◽  
Medical Devices ◽  
Biofilm Formation ◽  
Bacterial Biofilm

Studies of bacterial behavior in many environments have shown that most organisms attach to surfaces, forming communities of microcolonies called biofilms. In contaminated medical devices, biofilms may serve both as reservoirs and as inocula for the initiation of infections. Recently, there has been much concern about the potential of dental units to transmit infections. Because the mechanisms of biofilm formation are ill-defined, we investigated the behavior and formation of a biofilm associated with tubing leading to the water syringe of a dental unit over a period of 1 month.

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