Short-Pulse Laser-Based System for Detection of Tumors: Administration of Gold Nanoparticles Enhances Contrast

2012 ◽  
Vol 3 (2) ◽  
Author(s):  
A. Y. Sajjadi ◽  
A. Suratkar ◽  
K. Mitra ◽  
M. S. Grace
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Detection ◽  
Short Pulse ◽  
Detection System ◽  
Optical Tomography ◽  
Time Resolved ◽  
Optical Signals ◽  
Tomography System ◽  
Short Pulse Laser ◽  
Skin Cancer Detection

The objective of this paper is to demonstrate the use of gold nanoparticles, which accumulate in tumors due to the leakiness of tumor vasculature, as contrast agents for enhanced imaging in a time-resolved optical tomography system using short-pulse lasers for skin cancer detection in mouse model. It is found that intravenously administrated spherical gold nanoparticles broadened the temporal profile of reflected optical signals and enhanced the contrast between surrounding normal tissue and tumors. These results show that gold nanoparticles tuned to the wavelength of the laser can enhance the resolution and precision of laser-based cancer detection system.

Short-Pulse Laser-Based System for Detection of Tumors: Administration of Gold Nanoparticles Enhances Contrast

2011 ◽  
Author(s):  
A. Y. Sajjadi ◽  
A. Suratkar ◽  
K. Mitra ◽  
M. S. Grace
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Detection ◽  
Short Pulse ◽  
Optical Tomography ◽  
Pulsed Laser ◽  
Mouse Tissue ◽  
Time Resolved ◽  
Tomography System ◽  
Short Pulse Laser

The objective of this paper is to demonstrate the use of gold nanoparticles, which accumulate in tumors due to the leakiness of tumor vasculature, as contrast agents for enhanced imaging in a time-resolved optical tomography system using short-pulse lasers for skin cancer detection. Mouse tissue was analyzed in vivo by optical coherence tomography during exposure to the beam of either a 514nm, 200ps pulsed laser or a 776nm, 1.3ps pulsed laser. It was found that addition of spherical gold nanoparticles, either by injection under the skin or by intravenous administration, decreased total reflection intensity and broadened the temporal profile of reflected photons. Together, these results show that gold nanoparticles tuned to the wavelength of the laser can enhance contrast between labeled and unlabeled tissues, and suggest that gold nanoparticles may enhance the sensitivity and resolution of laser-based cancer detection and therapeutic treatment.

Time-resolved optical tomography using short-pulse laser for tumor detection

2006 ◽  
Vol 45 (24) ◽  
pp. 6270 ◽  
Author(s):  
Gopalendu Pal ◽  
Soumyadipta Basu ◽  
Kunal Mitra ◽  
Tuan Vo-Dinh
Keyword(s):  
Pulse Laser ◽  
Short Pulse ◽  
Optical Tomography ◽  
Tumor Detection ◽  
Time Resolved ◽  
Short Pulse Laser

Short-pulse Laser Induced Transient Structure Formation and Ablation Studied with Time-resolved Coherent XUV-scattering

2010 ◽  
Author(s):  
Klaus Sokolowski-Tinten ◽  
Anton Barty ◽  
Sebastien Boutet ◽  
Uladzimir Shymanovich ◽  
Henry Chapman ◽  
...  
Keyword(s):  
Structure Formation ◽  
Pulse Laser ◽  
Short Pulse ◽  
Time Resolved ◽  
Short Pulse Laser ◽  
Transient Structure

Some topical issues in research on short-pulse laser-produced plasmas

1980 ◽  
Vol 298 (1439) ◽  
pp. 351-364 ◽  
Keyword(s):  
Recent Work ◽  
Pulse Laser ◽  
Short Pulse ◽  
Fast Time ◽  
Physical Processes ◽  
Time Resolved ◽  
X Ray ◽  
Short Pulse Laser ◽  
Laser Facility ◽  
Interaction Phenomena

A brief review is presented of the main physical processes in laser-produced plasmas. This is followed by illustrations taken from recent work at the S.R.C. Central Laser Facility of the use of X-ray and visible streak cameras for fast time resolved measurements of implosion and interaction phenomena in laser-produced plasmas.

Dual Pump Femtosecond Laser Induced Plasma

2008 ◽  
Author(s):  
Meg Mahat ◽  
Tae Y. Choi ◽  
Nasrasadani Seifolah ◽  
Arup Neogi
Keyword(s):  
Emission Intensity ◽  
Short Pulse ◽  
Single Pulse ◽  
Atomic Emission ◽  
Dielectric Materials ◽  
Pulse Excitation ◽  
Time Resolved ◽  
Breakdown Spectroscopy ◽  
Short Pulse Laser ◽  
Ultra Short Pulse

Laser-induced breakdown spectroscopy (LIBS) can provide a noncontact way of inspecting a specimen including distinct signature of atomic composition of the sample. Ultra-short pulse laser enables characterization of any materials by utilizing the multiphoton process, which is a dominant carrier generation mechanism for dielectric materials. Additionally, femtosecond LIBS yields low background and better defined atomic lines than the nanosecond LIBS. We have performed a time-resolved emission intensity measurement for an iron oxide (Fe3O4, magnetite). The emission intensity has the peak value at 100 ps time delay, signifying that the succeeding pump beam is interacting with the plasma generated in the vicinity of the sample by the preceding beam. The dual pulses significantly enhance the atomic emission as compared to single pulse excitation and enables ultrafast time-resolved spectroscopy.

scholarly journals Space and time resolved measurement of surface magnetic field in high intensity short pulse laser matter interactions

2019 ◽  
Vol 26 (7) ◽  
pp. 072701
Author(s):  
Pierre Forestier-Colleoni ◽  
Dimitri Batani ◽  
Frédéric Burgy ◽  
Dario Del Sorbo ◽  
Fanny Froustey ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Pulse Laser ◽  
High Intensity ◽  
Short Pulse ◽  
Time Resolved ◽  
Surface Magnetic Field ◽  
Space And Time ◽  
Short Pulse Laser
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