scholarly journals Static and Dynamic Error of a Biplanar Videoradiography System Using Marker-Based and Markerless Tracking Techniques

2011 ◽  
Vol 133 (12) ◽  
Author(s):  
Daniel L. Miranda ◽  
Joel B. Schwartz ◽  
Andrew C. Loomis ◽  
Elizabeth L. Brainerd ◽  
Braden C. Fleming ◽  
...  
Keyword(s):  
Systematic Error ◽  
Gold Standard ◽  
High Speed ◽  
Angular Displacement ◽  
High Accuracy ◽  
Tracking Algorithm ◽  
Future Research ◽  
Markerless Tracking ◽  
Standard Instrumentation

The use of biplanar videoradiography technology has become increasingly popular for evaluating joint function in vivo. Two fundamentally different methods are currently employed to reconstruct 3D bone motions captured using this technology. Marker-based tracking requires at least three radio-opaque markers to be implanted in the bone of interest. Markerless tracking makes use of algorithms designed to match 3D bone shapes to biplanar videoradiography data. In order to reliably quantify in vivo bone motion, the systematic error of these tracking techniques should be evaluated. Herein, we present new markerless tracking software that makes use of modern GPU technology, describe a versatile method for quantifying the systematic error of a biplanar videoradiography motion capture system using independent gold standard instrumentation, and evaluate the systematic error of the W.M. Keck XROMM Facility’s biplanar videoradiography system using both marker-based and markerless tracking algorithms under static and dynamic motion conditions. A polycarbonate flag embedded with 12 radio-opaque markers was used to evaluate the systematic error of the marker-based tracking algorithm. Three human cadaveric bones (distal femur, distal radius, and distal ulna) were used to evaluate the systematic error of the markerless tracking algorithm. The systematic error was evaluated by comparing motions to independent gold standard instrumentation. Static motions were compared to high accuracy linear and rotary stages while dynamic motions were compared to a high accuracy angular displacement transducer. Marker-based tracking was shown to effectively track motion to within 0.1 mm and 0.1 deg under static and dynamic conditions. Furthermore, the presented results indicate that markerless tracking can be used to effectively track rapid bone motions to within 0.15 deg for the distal aspects of the femur, radius, and ulna. Both marker-based and markerless tracking techniques were in excellent agreement with the gold standard instrumentation for both static and dynamic testing protocols. Future research will employ these techniques to quantify in vivo joint motion for high-speed upper and lower extremity impacts such as jumping, landing, and hammering.

scholarly journals Biometric Measurement of Anterior Segment: A Review

Sensors ◽  
2020 ◽  
Vol 20 (15) ◽  
pp. 4285
Author(s):  
Bin Liu ◽  
Chengwei Kang ◽  
Fengzhou Fang
Keyword(s):  
High Speed ◽  
Anterior Segment ◽  
Future Research ◽  
Basic Principles ◽  
Human Eye ◽  
In Vivo Measurement ◽  
Research Perspectives ◽  
Scattering Effects ◽  
Fine Resolution

Biometric measurement of the anterior segment is of great importance for the ophthalmology, human eye modeling, contact lens fitting, intraocular lens design, etc. This paper serves as a comprehensive review on the historical development and basic principles of the technologies for measuring the geometric profiles of the anterior segment. Both the advantages and drawbacks of the current technologies are illustrated. For in vivo measurement of the anterior segment, there are two main challenges that need to be addressed to achieve high speed, fine resolution, and large range imaging. One is the motion artefacts caused by the inevitable and random human eye movement. The other is the serious multiple scattering effects in intraocular turbid media. The future research perspectives are also outlined in this paper.

A Reconfigurable High-Speed Stereo-Radiography System for Sub-Millimeter Measurement of In Vivo Joint Kinematics

2015 ◽  
Vol 9 (4) ◽  
Author(s):  
John C. Ivester ◽  
Adam J. Cyr ◽  
Michael D. Harris ◽  
Martin J. Kulis ◽  
Paul J. Rullkoetter ◽  
...  
Keyword(s):  
Motion Capture ◽  
Human Body ◽  
High Speed ◽  
Knee Kinematics ◽  
High Accuracy ◽  
Joint Motion ◽  
Radiography System ◽  
Rapid Sequence ◽  
Speed And Accuracy

Relative motions within normal and pathological joints of the human body can occur on the sub-millimeter and sub-degree scale. Dynamic radiography can be used to create a rapid sequence of images from which measurements of bone motion can be extracted, but available systems have limited speed and accuracy, limit normal subject movement, and do not easily integrate into existing traditional motion capture laboratories. A high-speed stereo radiography (HSSR) system is described that addresses these limitations. The custom radiography system was placed on a standalone reconfigurable gantry structure designed to allow freedom of subject movement while integrating into an existing motion capture laboratory. Validation of the system and measurement of knee kinematics of subjects during gait confirmed the ability to record joint motion with high accuracy and high-speed.

Metabolism and Distribution of Novel Tumor Targeting Drugs In Vivo

2020 ◽  
Vol 21 (13) ◽  
pp. 996-1008
Author(s):  
Mengli Wang ◽  
Qiuzheng Du ◽  
Lihua Zuo ◽  
Peng Xue ◽  
Chao Lan ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Small Molecule ◽  
High Efficiency ◽  
Tumor Therapy ◽  
Research Progress ◽  
Future Research ◽  
Pharmacokinetic Parameters ◽  
Molecular Characteristics ◽  
Targeted Drugs

Background: As a new tumor therapy, targeted therapy is becoming a hot topic due to its high efficiency and low toxicity. Drug effects of targeted tumor drugs are closely related to pharmacokinetics, so it is important to understand their distribution and metabolism in vivo. Methods: A systematic review of the literature on the metabolism and distribution of targeted drugs over the past 20 years was conducted, and the pharmacokinetic parameters of approved targeted drugs were summarized in combination with the FDA's drug instructions. Targeting drugs are divided into two categories: small molecule inhibitors and monoclonal antibodies. Novel targeting drugs and their mechanisms of action, which have been developed in recent years, are summarized. The distribution and metabolic processes of each drug in the human body are reviewed. Results: In this review, we found that the distribution and metabolism of small molecule kinase inhibitors (TKI) and monoclonal antibodies (mAb) showed different characteristics based on the differences of action mechanism and molecular characteristics. TKI absorbed rapidly (Tmax ≈ 1-4 h) and distributed in large amounts (Vd > 100 L). It was mainly oxidized and reduced by cytochrome P450 CYP3A4. However, due to the large molecular diameter, mAb was distributed to tissues slowly, and the volume of distribution was usually very low (Vd < 10 L). It was mainly hydrolyzed and metabolized into peptides and amino acids by protease hydrolysis. In addition, some of the latest drugs are still in clinical trials, and the in vivo process still needs further study. Conclusion: According to the summary of the research progress of the existing targeting drugs, it is found that they have high specificity, but there are still deficiencies in drug resistance and safety. Therefore, the development of safer and more effective targeted drugs is the future research direction. Meanwhile, this study also provides a theoretical basis for clinical accurate drug delivery.

Research on High-Speed Cutting of Cr12MoV Hardened Steel - A Review

2020 ◽  
Vol 15 ◽  
Author(s):  
Fei Sun ◽  
Guohe Li ◽  
Qi Zhang ◽  
Meng Liu
Keyword(s):  
High Speed ◽  
Cutting Temperature ◽  
High Hardness ◽  
High Strength ◽  
Hardened Steel ◽  
Parameters Optimization ◽  
Future Research ◽  
High Speed Machining ◽  
Machined Surface ◽  
Stamping Die

: Cr12MoV hardened steel is widely used in the manufacturing of stamping die because of its high strength, high hardness, and good wear resistance. As a kind of mainstream cutting technology, high-speed machining has been applied in the machining of Cr12MoV hardened steel. Based on the review of a large number of literature, the development of high-speed machining of Cr12MoV hardened steel was summarized, including the research status of the saw-tooth chip, cutting force, cutting temperature, tool wear, machined surface quality, and parameters optimization. The problems that exist in the current research were discussed and the directions of future research were pointed out. It can promote the development of high-speed machining of Cr12MoV hardened steel.

Review of Research on Hydrostatic Bearings

2020 ◽  
Vol 13 ◽  
Author(s):  
Xiaodong Yu ◽  
Yu Wang ◽  
Junfeng Wang ◽  
Wenkai Zhou ◽  
Hongwei Bi ◽  
...  
Keyword(s):  
High Speed ◽  
Static Pressure ◽  
Development Trend ◽  
Cnc Machining ◽  
Pressure Effects ◽  
Cnc Machine Tools ◽  
Future Research ◽  
Theoretical Formula ◽  
Hydrostatic Bearing ◽  
Hydrostatic Bearings

Background: Hydrostatic bearings have the advantages of strong bearing capacity, good stability, small friction coefficient and long life. The performance of liquid hydrostatic bearings directly affect the accuracy and efficiency of CNC machining equipment. The performance is conducive to the development of CNC machine tools towards high speed and heavy load, so it is necessary to sort out and summarize the existing research results. Objective: This study summarizes the current development status of hydrostatic bearings and explains the development trend of hydrostatic bearings. Methods: According to the recently published journal articles and patents, the recent experimental research on hydrostatic thrust bearings is summarized. This paper summarizes many factors that affect the performance of hydrostatic bearings, and discusses the causes of various factors on hydrostatic bearings. Finally, future research on hydrostatic bearings is presented. Results: The study discusses experimental methods, simulation processes, and experimental results. Conclusion: This study can produce dynamic and static pressure effects by changing the structure of the oil cavity of the hydrostatic bearing. This effect can make up for the static pressure loss. By improving the theoretical formula and mathematical model and proposing a new simulation method, the accuracy of the hydrostatic bearing simulation is satisfied; the future development trend of the hydrostatic bearing is proposed.

scholarly journals High-speed volumetric two-photon fluorescence imaging of neurovascular dynamics

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Jiang Lan Fan ◽  
Jose A. Rivera ◽  
Wei Sun ◽  
John Peterson ◽  
Henry Haeberle ◽  
...  
Keyword(s):  
Blood Flow ◽  
High Speed ◽  
Laser Scanning ◽  
Three Dimensional ◽  
Laser Scanning Microscopy ◽  
Fluorescence Signal ◽  
Imaging Method ◽  
Spatiotemporal Resolution ◽  
Two Photon

AbstractUnderstanding the structure and function of vasculature in the brain requires us to monitor distributed hemodynamics at high spatial and temporal resolution in three-dimensional (3D) volumes in vivo. Currently, a volumetric vasculature imaging method with sub-capillary spatial resolution and blood flow-resolving speed is lacking. Here, using two-photon laser scanning microscopy (TPLSM) with an axially extended Bessel focus, we capture volumetric hemodynamics in the awake mouse brain at a spatiotemporal resolution sufficient for measuring capillary size and blood flow. With Bessel TPLSM, the fluorescence signal of a vessel becomes proportional to its size, which enables convenient intensity-based analysis of vessel dilation and constriction dynamics in large volumes. We observe entrainment of vasodilation and vasoconstriction with pupil diameter and measure 3D blood flow at 99 volumes/second. Demonstrating high-throughput monitoring of hemodynamics in the awake brain, we expect Bessel TPLSM to make broad impacts on neurovasculature research.

scholarly journals Multi-Touch Interaction Generation Device by Spatiotemporally Switching Electrodes

Electronics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1475
Author(s):  
Masahiro Okamoto ◽  
Kazuya Murao
Keyword(s):  
High Speed ◽  
High Accuracy ◽  
Conductive Ink ◽  
Control Board ◽  
Touch Panel ◽  
Electrode Size ◽  
Touch Input ◽  
Touch Interaction ◽  
Multiple Electrodes ◽  
Touch Panels

With the spread of devices equipped with touch panels, such as smartphones, tablets, and laptops, the opportunity for users to perform touch interaction has increased. In this paper, we constructed a device that generates multi-touch interactions to realize high-speed, continuous, or hands-free touch input on a touch panel. The proposed device consists of an electrode sheet printed with multiple electrodes using conductive ink and a voltage control board, and generates eight multi-touch interactions: tap, double-tap, long-press, press-and-tap, swipe, pinch-in, pinch-out, and rotation, by changing the capacitance of the touch panel in time and space. In preliminary experiments, we investigated the appropriate electrode size and spacing for generating multi-touch interactions, and then implemented the device. From the evaluation experiments, it was confirmed that the proposed device can generate multi-touch interactions with high accuracy. As a result, tap, press-and-tap, swipe, pinch-in, pinch-out, and rotation can be generated with a success rate of 100%. It was confirmed that all the multi-touch interactions evaluated by the proposed device could be generated with high accuracy and acceptable speed.

scholarly journals Effect of Processing on Fish Protein Antigenicity and Allergenicity

Foods ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 969
Author(s):  
Xingyi Jiang ◽  
Qinchun Rao
Keyword(s):  
Fish Species ◽  
Protein Denaturation ◽  
Ex Vivo ◽  
Protein Solubility ◽  
Future Research ◽  
Food Protein ◽  
In Vivo Evaluation ◽  
Fish Allergy

Fish allergy is a life-long food allergy whose prevalence is affected by many demographic factors. Currently, there is no cure for fish allergy, which can only be managed by strict avoidance of fish in the diet. According to the WHO/IUIS Allergen Nomenclature Sub-Committee, 12 fish proteins are recognized as allergens. Different processing (thermal and non-thermal) techniques are applied to fish and fishery products to reduce microorganisms, extend shelf life, and alter organoleptic/nutritional properties. In this concise review, the development of a consistent terminology for studying food protein immunogenicity, antigenicity, and allergenicity is proposed. It also summarizes that food processing may lead to a decrease, no change, or even increase in fish antigenicity and allergenicity due to the change of protein solubility, protein denaturation, and the modification of linear or conformational epitopes. Recent studies investigated the effect of processing on fish antigenicity/allergenicity and were mainly conducted on commonly consumed fish species and major fish allergens using in vitro methods. Future research areas such as novel fish species/allergens and ex vivo/in vivo evaluation methods would convey a comprehensive view of the relationship between processing and fish allergy.

High speed long-term visual object tracking algorithm for real robot systems

2021 ◽  
Vol 434 ◽  
pp. 268-284
Author(s):  
Muxi Jiang ◽  
Rui Li ◽  
Qisheng Liu ◽  
Yingjing Shi ◽  
Esteban Tlelo-Cuautle
Keyword(s):  
Object Tracking ◽  
High Speed ◽  
Tracking Algorithm ◽  
Visual Object ◽  
Visual Object Tracking ◽  
Robot Systems ◽  
Real Robot

scholarly journals The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 132
Author(s):  
Nilufar Z. Mamadalieva ◽  
Davlat Kh. Akramov ◽  
Ludger A. Wessjohann ◽  
Hidayat Hussain ◽  
Chunlin Long ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Chemical Constituents ◽  
Iridoid Glycosides ◽  
Herbal Medicines ◽  
Future Research ◽  
South Central ◽  
Pharmacological Studies ◽  
Central South

The genus Lagochilus (Lamiaceae) is native to Central, South-Central, and Eastern Asia. It comprises 44 species, which have been commonly used as herbal medicines for the treatments of various ailments for thousands of years, especially in Asian countries. This review aims to summarize the chemical constituents and pharmacological activities of species from the genus Lagochilus to unveil opportunities for future research. In addition, we provide some information about their traditional uses, botany, and diversity. More than 150 secondary metabolites have been reported from Lagochilus, including diterpenes, flavonoids, phenolic compounds, triterpenoids, iridoid glycosides, lignans, steroids, alkaloids, polysaccharides, volatile, non-volatile and aromatic compounds, lipids, carbohydrates, minerals, vitamins, and other secondary metabolites. In vitro and in vivo pharmacological studies on the crude extracts, fractions, and isolated compounds from Lagochilus species showed hemostatic, antibacterial, anti-inflammatory, anti-allergic, cytotoxic, enzyme inhibitory, antispasmodic, hypotensive, sedative, psychoactive, and other activities.

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